Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia

European Journal of Cancer

Volumn 41, Issue 4, 2005, Pages 584-589

  Tsellou, Erasmia ^a   Troungos, Constantinos ^a   Moschovi, Maria ^a   Athanasiadou Piperopoulou, Fani ^b   Polychronopoulou, Sophia ^c   Kosmidis, Helen ^d   Kalmanti, Maria ^e   Hatzakis, Angelos ^a   Dessypris, Nick ^a   Kalofoutis, Anastasios ^a   Petridou, Eleni ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^d P AND A KYRIAKOU CHILDREN S HOSPITAL   (Greece)

^e UNIVERSITY OF CRETE   (Greece)

Author keywords

Acute lymphoblastic leukaemia; Acute myeloid; CpG island; Cyclin dependent kinase inhibitors; Hypermethylation

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; GENE ACTIVITY; GENE FUNCTION; HUMAN; MALE; METHYLATION; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE;

EID: 20044387032     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2004.12.010     Document Type: Article

References (33)

1. A. Bird DNA methylation and epigenetic memory Genes Dev 16 2002 6 21
2. S.H. Cross, and A. Bird CpG islands and genes Curr Opin Genet Dev 5 1995 309 314
3. E. Li Chromatin modification and epigenetic reprogramming in mammalian development Nature Rev Genet 3 2002 662 673
4. M.S. Turker Gene silencing in mammalian cells and the spread of DNA methylation Oncogene 21 2002 5388 5393
5. P.A. Jones DNA methylation and cancer Oncogene 21 2002 5358 5360
6. M. Hengstschlager, K. Braun, and T. Soucek Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle Mutat Res 436 1999 1 9
7. P.D. Jeffrey, L. Tong, and N.P. Pavletich Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors Genes Dev 14 2000 3115 3125
8. INK4D) in human acute myeloid leukemia and normal myeloid cells Leukemia 11 1997 54 63
9. S. Stone, P. Dayananth, and P. Jiang Genomic structure, expression and mutational analysis of the p15 (MTS2) gene Oncogene 11 1995 987 991
10. Sved Erickson, Olle Sangfelt, and Mats Heyman Involvement of the Ink4 proteins p16 and p15 in T-lymphocytes senescence Oncogene 17 1998 595 602
11. T. Nobori, K. Miura, and D.J. Wu Deletions of the cyclin-dependent Kinase-4 inhibitor gene in multiple human cancers Nature 368 1994 753 756
12. A. Merlo, J.G. Herman, and L. Mao 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers Nat Med 1 1995 686 692
13. C.S. Chim, R. Liang, and Y.L. Kwong Hypermethylation of gene promoters in hematological neoplasia Hematol Oncol 20 2002 167 176
14. A. Batova, M.B. Diccianni, and J.C. Yu Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukaemia Cancer Res 57 1997 832 836
15. T. Uchida, T. Kinoshita, and H. Saito CDKN2 (MTS1/p16INK4A) gene alterations in hematological malignancies Leukemia Lymphoma 24 1997 449 461
16. INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation Brit J Haematol 112 2001 148 154
17. J.G. Herman, C.I. Civin, and J.P. Issa Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies Cancer Res 57 1997 837 841
18. I.H.N. Wong, M.H. Ng, and D.P. Huang Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications Blood 95 2000 1942 1949
19. G.M. Guillermo, S. Jeha, and J. Daniel Aberrant DNA methylation in pediatric patients with acute lymphoblastic leukemia Cancer 97 2003 695 702
20. T. Kalebic Epigenetic changes: potential therapeutic targets Ann NY Acad Sci 983 2003 278 285
21. E. Petridou, D. Trichopoulos, and V. Kalapothaki The risk profile of childhood leukaemia in Greece: a nationwide case-control study Brit J Cancer 76 1997 1241 1247
22. E. Petridou, M. Dalamaga, and A. Mentis Evidence on the infectious etiology of childhood leukemia: the role of low herd immunity (Greece) Cancer Causes Contr. 12 2001 645 652
23. E. Petridou, A. Skalkidou, and N. Dessypris Endogenous risk factors for childhood leukemia in relation to the IGF system (Greece) Cancer Causes Contr. 11 2000 765 771
24. E. Petridou, A.E. Klimentopoulou, and M. Moustaki Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies Int J Cancer 101 2002 74 77
25. J.G. Herman, J.R. Graff, and S. Myohanen Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 1996 9821 9826
26. M. Iravani, R. Dhat, and C.M. Price Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, P15INK4B) in childhood acute lymphoblastic leukemia Oncogene 15 1997 2609 2614
27. K.W. Maloney, L. McGavran, and L.F. Odom Acquisition of p16INK4A and p15INK4B abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia Blood 93 1999 2380 2385
28. S.X. Guo, T. Taki, and H. Ohnishi Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia Leuk Res 24 2000 39 46
29. INK4B methylation in acute myeloid leukemia Cancer Res 59 1999 436 441
30. M. Gonzalez-Zulueta, C.M. Bender, and A.S. Yang Methylation of the 5′ end CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing Cancer Res 55 1995 4531 4535
31. K. Sakashita, K. Koike, and T. Kinoshita Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development J Clin Invest 108 2001 1195 1204
32. J.K. Christman 5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy Oncogene 21 2002 5483 5495
33. M. Daskalakis, T.T. Nguyen, and C. Nguyen Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment Blood 100 2002 2957 2964