Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor

Molecular Pharmacology

Volumn 59, Issue 3, 2001, Pages 612-618

  Ahmadi, Seifollah ^a   Kotalla, Carolin ^a   Gühring, Hans ^a   Takeshima, Hiroshi ^b   Pahl, Andreas ^a   Zeilhofer, Hanns Ulrich ^a,c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b KURUME UNIVERSITY   (Japan)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AMPA RECEPTOR; FORMALDEHYDE; GLUTAMATE RECEPTOR; GLYCINE RECEPTOR; NEUROPEPTIDE; NOCICEPTIN; NOCICEPTIN RECEPTOR; NOCISTATIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; HORMONE ACTION; MALE; MOUSE; NOCICEPTION; NONHUMAN; PATCH CLAMP; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION;

EID: 0035122795     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.3.612     Document Type: Article

References (47)

1. The role of the ORL1 receptor in the modulation of spinal neurotransmission by nociceptin orphanin FQ and nocistatin
2. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type
3. Pharmacology of nociceptin and its receptor: A novel therapeutic target
4. 154-181 effects on calcium channel currents and a potassium current in rat locus coeruleus in vitro
5. Infrared videomicroscopy: A new look at neuronal structure and function
6. The dorsal horn: State-dependent sensory processing, plasticity and the generation of pain
7. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
8. Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test
9. cDNA cloning and regional distribution of a novel member of the opioid receptor family
10. Multiple opioid receptors: Ligand selectivity profiles and binding site signatures
11. A new selective antagonist of the nociceptin receptor
12. Structure and regional distribution of nociceptin/orphanin FQ precursor
13. Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: A study using in situ hybridization and X-gal histochemistry in receptor-deficient mice
14. Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord
15. A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: Anxiolytic profile in the rat
16. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
17. 10]orphanin FQ/nociceptin(1-11) binding sites in rat brain
18. Modulation of excitatory synaptic transmission by nociceptin in superficial dorsal horn neurones of the neonatal rat spinal cord
19. Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain
20. Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to nociceptin/orphanin FQ
21. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
22. Anti-nociceptive responses produced by human putative counterpart of nocistatin
23. Orphanin FQ is a functional anti-opioid peptide
24. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization
25. Effect of intrathecal nocistatin on the formalin-induced pain in mice versus that of nociceptin/orphanin FQ
26. 35S]-GTPγS binding and immunohistochemistry
27. Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices
28. Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphanin FQ receptor
29. Structure and chromosomal mapping of genes for the mouse kappa-opioid receptor and an opioid receptor homologue (MOR-C)
30. Primary structure and tissue distribution of the orphanin FQ precursor
31. Nocistatin, a peptide that blocks nociceptin action in pain transmission
32. Cloning and expression of a cDNA encoding a mouse brain orphanin FQ/nociceptin precursor
33. Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain
34. A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin
35. Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor
36. Orphanin FQ a neuropeptide that activates an opioidlike G protein-coupled receptor
37. Analgesic activity of orphanin FQ2, murine prepro-orphanin FQ141-157 in mice
38. N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin
39. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: Antagonism in brain and potentiation in spinal cord of the rat
40. Endogenous orphanin FQ: Evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture
41. How opioids inhibit GABA-mediated neurotransmission
42. cDNA cloning of an orphan opiate receptor gene family member and its splice variant
43. Effects of intrathecal nocistatin on the flexor reflex and its interaction with orphanin FQ nociceptin
44. Nociceptin or antinociceptin: Potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat
45. Central pharmacology of nociceptive transmission
46. Selective suppression of inhibitory synaptic transmission by nocistatin in the rat spinal cord dorsal horn
47. Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia