Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years

American Journal of Epidemiology

Volumn 150, Issue 3, 1999, Pages 301-305

  Grandjean, Philippe ^a,b,f   Budtz Jørgensen, Esben ^c   White, Roberta F ^a,b   Jørgensen, Poul J ^d   Weihe, Pal ^a,e   Debes, Frodi ^e   Keiding, Niels ^c  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

^e FAROESE HOSPITAL SYSTEM   (Faroe Islands)

^f Department of Environmental Medicine ^*  (Denmark)

Author keywords

Assessment, risk; Child, preschool; Environmental pollution; Food contamination; Neuropsychological tests; Prenatal exposure delayed effects

Indexed keywords

BIOLOGICAL MARKER; METHYLMERCURY;

BIOMARKER; CHILD HEALTH; METHYLMERCURY;

ARTICLE; ATTENTION DEFICIT DISORDER; BLOOD LEVEL; CHILD; CHILD DEVELOPMENT; DEVELOPMENTAL DISORDER; FAROE ISLANDS; FOOD CONTAMINATION; HUMAN; INFANT; LANGUAGE DISABILITY; MAJOR CLINICAL STUDY; MERCURIALISM; MOTOR COORDINATION; NEUROPSYCHOLOGICAL TEST; NEUROTOXICITY; NEWBORN; PERINATAL PERIOD; PRENATAL EXPOSURE; PRENATAL PERIOD; SCALP HAIR; SPATIAL MEMORY; UMBILICAL CORD BLOOD; VISUAL MEMORY;

FAROE ISLANDS;

EID: 0033180335     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.aje.a010002     Document Type: Article

References (28)

1. Grandjean P, Weihe P, Nielsen JB. Methylmercury: significance of intrauterine and postnatal exposures. Clin Chem 1994;40:1395-1400.
2. Grandjean P, Weihe P, White RF, et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997;19:417-28.
3. Dobbing J. Vulnerable periods in developing brain. In: Davison AN, Dobbing J, eds. Applied neurochemistry. Philadelphia, PA: Davis, 1968:287-316.
4. Mercury study report to Congress. Washington, DC: US Environmental Protection Agency, 1997.
5. Reynolds WA, Pitkin RM. Transplacental passage of methylmercury and its uptake by primate fetal tissues. Proc Soc Exp Biol Med 1975;148:523-6.
6. Amin-Zaki L, Majeed MA, Greenwood MR, et al. Methylmercury poisoning in the Iraqi suckling infant: a longitudinal study over five years. J Appl Toxicol 1981;1:210-14.
7. Sherlock J, Hislop J, Newton D, et al. Elevation of mercury in human blood from controlled chronic ingestion of methylmercury in fish. Hum Toxicol 1984;3:117-31.
8. Nielsen JB, Andersen O, Grandjean P. Evaluation of mercury in hair, blood and muscle as biomarkers for methylmercury exposure in male and female mice. Arch Toxicol 1994; 68:317-21.
9. Grandjean P, Weihe P, Jørgensen PJ, et al. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch Environ Health 1992;47:185-95.
10. Smith JC, Farris FF. Methyl mercury pharmacokinetics in man: a reevaluation. Toxicol Appl Pharmacol 1996;137: 245-52.
11. Clarkson TW, Hursh JB, Sager PR, et al. Mercury. In: Clarkson TW, Friberg L, Nordberg GF, et al., eds. Biological monitoring of toxic metals. New York, NY: Plenum Press, 1988:199-246.
12. Yamaguchi S, Matsumoto H, Kaku S, et al. Factors affecting the amount of mercury in human scalp hair. Am J Public Health 1975;65:484-8.
13. Harada M. Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol 1995;25:1-24.
14. Davidson PW, Myers G, Cox C, et al. Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicology 1995;16: 677-88.
15. Grandjean P, Jørgensen PJ, Weihe P. Methylmercury from mother's milk: accumulation in infants. Environ Health Perspect 1994;102:74-7.
16. Letz R, Baker EL. NES2, neurobehavioral evaluation system manual. Winchester, MA: Neurobehavioral Systems, 1988.
17. Dahl R, White RF, Weihe P, et al. Feasibility and validity of three computer-assisted neurobehavioral tests in 7-year-old children. Neurotoxicol Teratol 1996;18:413-19.
18. Wechsler D. Wechsler intelligence scale for children-revised. New York, NY: Psychological Corp., 1974.
19. Schlange H, Stein B, von Boetticher I, et al. Göttinger Formreproduktions-Test. (In German). Göttingen, Germany: Verlag für Psychologie, 1977.
20. Kaplan E, Goodglass H, Weintraub S. The Boston Naming Test. Philadelphia, PA: Lea and Febiger, 1983.
21. Delis DC, Kramer JH, Kaplan E, et al. California verbal learning test (children). San Antonio, TX: Psychological Corp., 1994.
22. Raven J. Standard progressive matrices. London, England: H. K. Lewis, 1958.
23. Kjellström T, Kennedy P, Wallis S. Physical and mental development of children with prenatal exposure to mercury from fish. Stage 2. Interviews and psychological tests at age 6. (Report 3642). Stockholm, Sweden: National Swedish Environmental Protection Board, 1989.
24. Marsh DO, Clarkson TW, Cox C, et al. Fetal methylmercury poisoning, relationship between concentrations in single strand of maternal hair and child effects. Arch Neurol 1987;44: 1017-22.
25. Davis LE, Kornfeld M, Mooney HS, et al. Methylmercury poisoning: long-term clinical, radiological, texicological, and pathological studies of an affected family. Ann Neurol 1994;35:680-8.
26. Grandjean P, Weihe P, White RF. Milestone development in infants exposed to methylmercury from human milk. Neurotoxicol 1995;16:27-33.
27. Takeuchi T, Morikawa N, Matsumoto H, et al. A pathological study of Minamata disease in Japan. Acta Neuropathol 1962;2:40-57.
28. Choi BH. The effects of methylmercury on the developing brain. Progr Neurobiol 1989;32:447-70.