Major histocompatibility complex class II presentation of cell-associated antigen is mediated by CD8α+ dendritic cells in vivo

Journal of Experimental Medicine

Volumn 195, Issue 6, 2002, Pages 683-694

  Valdez, Yanet ^a   Mah, Weiling ^a   Winslow, Monte M ^a   Xu, Lixin ^a   Ling, Peter ^a   Townsend, Sarah E ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antigen presenting cells; B cells; Dendritic cells; Flow cytometry; T cells

Indexed keywords

CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD8; B-LYMPHOCYTES; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPHOCYTE COOPERATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; T-LYMPHOCYTES;

EID: 0037128649     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20010898     Document Type: Article

References (46)

1. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
2. Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo
3. B cells acquire antigen from target cells after synapse formation
4. B lymphocytes secrete antigen-presenting vesicles
5. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
6. Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
7. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
8. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells
9. TCR-mediated internalization of peptide-MHC complexes acquired by T cells
10. Antigen presentation by hapten-specific B lymphocytes: Role of surface immunoglobulin receptors
11. Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: Importance depends on the nature of the antigen-antibody interaction
12. Igα a and Igβ are required for efficient trafficking to late endosomes and to enhance antigen presentation
13. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells
14. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
15. + T cells
16. Determination of lymphocyte division by flow cytometry
17. Quantitative analysis of the T cell repertoire that escapes negative selection
18. Inhibition of thymocyte positive selection by natural MHC: Peptide ligands
19. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
20. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
21. Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo
22. The development, maturation, and turnover rate of mouse spleen dendritic cell populations
23. Dendritic cells in the T-cell areas of lymphoid organs
24. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion
25. Dendritic cells and the control of immunity
26. The induction of tolerance by dendritic cells that have captured apoptotic cells
27. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
28. Differential production of IL-12, IFN-α, and IFN-γ by mouse dendritic cell subsets
29. + and CD8α-subclasses of dendritic cells direct the development of distinct T helper cells in vivo
30. Reciprocal control of T helper cell and dendritic cell differentiation
31. Dendritic cell lineage, plasticity and cross-regulation
32. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures
33. A subclass of dendritic cells kill CD4 T cells via Fas/Fas-ligand-induced apoptosis
34. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay
35. Cross-presentation: A general mechanism for CTL immunity and tolerance
36. + T-cell tolerance by cross-presentation of self antigens
37. - dendritic cells cross-prime cytotoxic T cells in vivo
38. The biochemistry and cell biology of antigen processing and presentation
39. Dendritic cells acquire antigens from live cells for cross-presentation of CTL
40. + dendritic cells
41. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
42. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
43. Natural adjuvants: Endogenous activators of dendritic cells
44. Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate
45. Decay-accelerating factor (CD55) and membrane inhibitor of reactive lysis (CD59) are released within exosomes during In vitro maturation of reticulocytes
46. Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules