Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: Role of inducible nitric-oxide synthase and oxidative stress

Journal of Pharmacology and Experimental Therapeutics

Volumn 312, Issue 3, 2005, Pages 945-953

  Virdis, Agostino ^a   Colucci, Rocchina ^a   Fornai, Matteo ^a   Blandizzi, Corrado ^a   Duranti, Emiliano ^a   Pinto, Stefania ^a   Bernardini, Nunzia ^a   Segnani, Cristina ^a   Antonioli, Luca ^a   Taddei, Stefano ^a   Salvetti, Antonio ^a   Del Tacca, Mario ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 5,5 DIMETHYL 3 (3 FLUOROPHENYL) 4 (4 METHYLSULPHONYL)PHENYL 2(5H) FURANONE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACETYLCHOLINE; ASCORBIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; N(G) METHYLARGININE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; REACTIVE OXYGEN METABOLITE; S METHYLPSEUDOTHIOUREA; SUPEROXIDE DISMUTASE; THROMBOXANE A2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DIAMETER; ARTERY ENDOTHELIUM; ARTERY RESISTANCE; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM LESION; ENDOTOXEMIA; ENZYME INHIBITION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MESENTERIC ARTERY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA; SEPTIC SHOCK; UPREGULATION; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANIMALS; ASCORBIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOKINES; ENDOTHELIUM, VASCULAR; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NOREPINEPHRINE; OMEGA-N-METHYLARGININE; OXIDATIVE STRESS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHOCK, SEPTIC; SUPEROXIDE DISMUTASE; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 20044369915     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.077644     Document Type: Article

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