-
1
-
-
0036479747
-
Roles of ERBB family receptor tyrosine kinases and downstream signaling pathways in the control of cell growth and survival
-
Grant S, Qiao L, Dent P. Roles of ERBB family receptor tyrosine kinases and downstream signaling pathways in the control of cell growth and survival. Front Biosci 2002;7:376-89.
-
(2002)
Front Biosci.
, vol.7
, pp. 376-389
-
-
Grant, S.1
Qiao, L.2
Dent, P.3
-
2
-
-
0034059884
-
Signal transduction and cellular radiation responses
-
Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB, Valerie K. Signal transduction and cellular radiation responses. Radiat Res 2000;153: 245-57.
-
(2000)
Radiat. Res.
, vol.153
, pp. 245-257
-
-
Schmidt-Ullrich, R.K.1
Dent, P.2
Grant, S.3
Mikkelsen, R.B.4
Valerie, K.5
-
4
-
-
0032815618
-
Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
-
Dent P, Reardon DB, Park JS, et al. Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol Biol Cell 1999;10:2493-506.
-
(1999)
Mol. Biol. Cell.
, vol.10
, pp. 2493-2506
-
-
Dent, P.1
Reardon, D.B.2
Park, J.S.3
-
5
-
-
0032740247
-
Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells
-
Park JS, Carter S, Reardon DB, Schmidt-Ullrich R, Dent P, Fisher PB. Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells. Mol Biol Cell 1999;10: 4231-46.
-
(1999)
Mol. Biol. Cell.
, vol.10
, pp. 4231-4246
-
-
Park, J.S.1
Carter, S.2
Reardon, D.B.3
Schmidt-Ullrich, R.4
Dent, P.5
Fisher, P.B.6
-
6
-
-
0035879004
-
Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells
-
Suzuki K, Kodama S, Watanabe M. Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. Cancer Res 2001;61:5396-401.
-
(2001)
Cancer Res.
, vol.61
, pp. 5396-5401
-
-
Suzuki, K.1
Kodama, S.2
Watanabe, M.3
-
7
-
-
0035379644
-
Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation
-
Fanton CP, McMahon M, Pieper RO. Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. J Biol Chem 2001;276:18871-7.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18871-18877
-
-
Fanton, C.P.1
McMahon, M.2
Pieper, R.O.3
-
8
-
-
0035974818
-
RAS adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy
-
Ludde T, Kubicka S, Plumpe J, Liedtke C, Manns MP, Trautwein C. RAS adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy. Oncogene 2001;20:5264-78.
-
(2001)
Oncogene
, vol.20
, pp. 5264-5278
-
-
Ludde, T.1
Kubicka, S.2
Plumpe, J.3
Liedtke, C.4
Manns, M.P.5
Trautwein, C.6
-
10
-
-
0035964458
-
RAS and Rho regulation of the cell cycle and oncogenesis
-
Pruitt K, Der CJ. RAS and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 2001;171:1-10.
-
(2001)
Cancer Lett.
, vol.171
, pp. 1-10
-
-
Pruitt, K.1
Der, C.J.2
-
11
-
-
0032843987
-
Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides
-
Sizemore N, Cox AD, Barnard JA, et al. Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides. Gastroenterology 1999;117: 567-76.
-
(1999)
Gastroenterology
, vol.117
, pp. 567-576
-
-
Sizemore, N.1
Cox, A.D.2
Barnard, J.A.3
-
12
-
-
0345060033
-
ΔRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry
-
Balmanno K, Millar T, McMahon M, Cook SJ. ΔRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Mol Cell Biol 2003;23:9303-17.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9303-9317
-
-
Balmanno, K.1
Millar, T.2
McMahon, M.3
Cook, S.J.4
-
13
-
-
0037938663
-
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: Identification of an Achilles heel in leukemia
-
Blalock WL, Navolanic PM, Steelman LS, et al. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia. Leukemia 2003;17: 1058-67.
-
(2003)
Leukemia
, vol.17
, pp. 1058-1067
-
-
Blalock, W.L.1
Navolanic, P.M.2
Steelman, L.S.3
-
14
-
-
1642553461
-
The dark side of Ras: Regulation of apoptosis
-
Cox AD, Der CJ. The dark side of Ras: regulation of apoptosis. Oncogene 2003;22:8999-9006.
-
(2003)
Oncogene
, vol.22
, pp. 8999-9006
-
-
Cox, A.D.1
Der, C.J.2
-
15
-
-
0023835721
-
The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation
-
Sklar MD. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 1988;239:645-7.
-
(1988)
Science
, vol.239
, pp. 645-647
-
-
Sklar, M.D.1
-
16
-
-
0034104590
-
The RAS branch of small GTPases: RAS family members don't fall far from the tree
-
Reuther GW, Der CJ. The RAS branch of small GTPases: RAS family members don't fall far from the tree. Curr Opin Cell Biol 2000;12:157-65.
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 157-165
-
-
Reuther, G.W.1
Der, C.J.2
-
17
-
-
0035834663
-
Heregulin-dependent activation of phosphoinositide 3-kinase and AKT via the ERBB2/ERBB3 co-receptor
-
Hellyer NJ, Kim MS, Koland JG. Heregulin-dependent activation of phosphoinositide 3-kinase and AKT via the ERBB2/ERBB3 co-receptor. J Biol Chem 2001;276:42153-61.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42153-42161
-
-
Hellyer, N.J.1
Kim, M.S.2
Koland, J.G.3
-
18
-
-
0033835421
-
The importance of being K-RAS
-
Ellis CA, Clark G. The importance of being K-RAS. Cell Signal 2000;12:425-34.
-
(2000)
Cell Signal
, vol.12
, pp. 425-434
-
-
Ellis, C.A.1
Clark, G.2
-
19
-
-
0032508517
-
RAS isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
-
Yan J, Roy S, Apolloni A, Lane A, Hancock JF. RAS isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J Biol Chem 1998;273:24052-6.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24052-24056
-
-
Yan, J.1
Roy, S.2
Apolloni, A.3
Lane, A.4
Hancock, J.F.5
-
20
-
-
0034807142
-
Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity
-
Liebmann C. Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity. Cell Signal 2001; 13: 777-85.
-
(2001)
Cell Signal
, vol.13
, pp. 777-785
-
-
Liebmann, C.1
-
21
-
-
0035522657
-
Inhibition of Kirsten RAS expression in human colorectal cancer using rationally selected Kirsten-RAS antisense oligonucleotides
-
Ross PJ, George M, Cunningham D, et al. Inhibition of Kirsten RAS expression in human colorectal cancer using rationally selected Kirsten-RAS antisense oligonucleotides. Mol Cancer Ther 2001;1:29-41.
-
(2001)
Mol. Cancer Ther.
, vol.1
, pp. 29-41
-
-
Ross, P.J.1
George, M.2
Cunningham, D.3
-
22
-
-
0034671497
-
Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells
-
Baba I, Shirasawa S, Iwamoto R, et al. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells. Cancer Res 2000;60: 6886-9.
-
(2000)
Cancer Res.
, vol.60
, pp. 6886-6889
-
-
Baba, I.1
Shirasawa, S.2
Iwamoto, R.3
-
24
-
-
0028103920
-
Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures
-
Schmidt-Ullrich RK, Valerie KC, Chan W, McWilliams D. Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures. Int J Radiat Oncol Biol Phys 1994;29:813-9.
-
(1994)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.29
, pp. 813-819
-
-
Schmidt-Ullrich, R.K.1
Valerie, K.C.2
Chan, W.3
McWilliams, D.4
-
26
-
-
4444230648
-
Ionizing radiation causes a dose-dependent release of the growth factor TGFα in vitro, from irradiated xenografts, and during the palliative treatment of patients suffering from hormone refractory prostate carcinoma
-
Hagan MP, Yacoub A, Dent P. Ionizing radiation causes a dose-dependent release of the growth factor TGFα in vitro, from irradiated xenografts, and during the palliative treatment of patients suffering from hormone refractory prostate carcinoma. Clin Cancer Res 2004;10: 5724-31.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 5724-5731
-
-
Hagan, M.P.1
Yacoub, A.2
Dent, P.3
-
27
-
-
0032894222
-
Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines
-
Putz T, Culig Z, Eder IE, et al. Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines. Cancer Res 1999;59:227-33.
-
(1999)
Cancer Res.
, vol.59
, pp. 227-233
-
-
Putz, T.1
Culig, Z.2
Eder, I.E.3
-
28
-
-
9144251955
-
Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways
-
Choi JA, Park MT, Kang CM, et al. Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways. Oncogene 2004;23:9-20.
-
(2004)
Oncogene
, vol.23
, pp. 9-20
-
-
Choi, J.A.1
Park, M.T.2
Kang, C.M.3
-
29
-
-
0032575135
-
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells
-
Carter S, Auer KL, Reardon DB, et al. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells. Oncogene 1998;16:2787-96.
-
(1998)
Oncogene
, vol.16
, pp. 2787-2796
-
-
Carter, S.1
Auer, K.L.2
Reardon, D.B.3
-
30
-
-
0031806483
-
Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation
-
Kavanagh BD, Dent P, Schmidt-Ullrich RK, Chen P, Mikkelsen RB. Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation. Radiat Res 1998; 149:579-87.
-
(1998)
Radiat. Res.
, vol.149
, pp. 579-587
-
-
Kavanagh, B.D.1
Dent, P.2
Schmidt-Ullrich, R.K.3
Chen, P.4
Mikkelsen, R.B.5
-
32
-
-
0027905014
-
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
-
Shirasawa S, Furuse M, Yokoyama N, Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 1993; 260:85-8.
-
(1993)
Science
, vol.260
, pp. 85-88
-
-
Shirasawa, S.1
Furuse, M.2
Yokoyama, N.3
Sasazuki, T.4
-
33
-
-
0029014973
-
Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases
-
Dent P, Jelinek T, Morrison DK, Weber MJ, Sturgill TW. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. Science 1995;268:1902-6.
-
(1995)
Science
, vol.268
, pp. 1902-1906
-
-
Dent, P.1
Jelinek, T.2
Morrison, D.K.3
Weber, M.J.4
Sturgill, T.W.5
-
34
-
-
0029042701
-
Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro
-
Dent P, Reardon DB, Morrison DK, Sturgill TW. Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro. Mol Cell Biol 1995;15:4125-35.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4125-4135
-
-
Dent, P.1
Reardon, D.B.2
Morrison, D.K.3
Sturgill, T.W.4
-
35
-
-
0034548724
-
Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines
-
Bernhard EJ, Stanbridge EJ, Gupta S, et al. Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines. Cancer Res 2000;60: 6597-600.
-
(2000)
Cancer Res.
, vol.60
, pp. 6597-6600
-
-
Bernhard, E.J.1
Stanbridge, E.J.2
Gupta, S.3
-
36
-
-
0036304685
-
Local recurrence in head and neck cancer: Relationship to radiation resistance and signal transduction
-
Gupta AK, McKenna WG, Weber CN, et al. Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clin Cancer Res 2002;8:885-92.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 885-892
-
-
Gupta, A.K.1
McKenna, W.G.2
Weber, C.N.3
-
37
-
-
0038281227
-
Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002
-
Gupta AK, Cerniglia GJ, Mick R, et al. Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. Int J Radiat Oncol Biol Phys 2003;56:846-53.
-
(2003)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.56
, pp. 846-853
-
-
Gupta, A.K.1
Cerniglia, G.J.2
Mick, R.3
-
38
-
-
0037030519
-
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
-
Contessa JN, Hampton J, Lammering G, et al. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene 2002;21:4032-41.
-
(2002)
Oncogene
, vol.21
, pp. 4032-4041
-
-
Contessa, J.N.1
Hampton, J.2
Lammering, G.3
-
40
-
-
0037089516
-
Inhibition of radiation-induced nuclear factor-κB activation by an anti-Ras single-chain antibody fragment: Lack of involvement in radiosensitization
-
Russell JS, Raju U, Gumin GJ, et al. Inhibition of radiation-induced nuclear factor-κB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization. Cancer Res 2002;62:2318-26.
-
(2002)
Cancer Res.
, vol.62
, pp. 2318-2326
-
-
Russell, J.S.1
Raju, U.2
Gumin, G.J.3
-
41
-
-
0035955691
-
A direct interaction between oncogenic Ha-Ras and phosphatidylinositol 3-kinase is not required for Ha-Ras-dependent transformation of epithelial cells
-
Karasarides M, Anand-Apte B, Wolfman A. A direct interaction between oncogenic Ha-Ras and phosphatidylinositol 3-kinase is not required for Ha-Ras-dependent transformation of epithelial cells. J Biol Chem 2001;276:39755-64.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39755-39764
-
-
Karasarides, M.1
Anand-Apte, B.2
Wolfman, A.3
-
42
-
-
0141869078
-
The RAS signal transduction pathway and its role in radiation sensitivity
-
McKenna WG, Muschel RJ, Gupta AK, Hahn SM, Bernhard EJ. The RAS signal transduction pathway and its role in radiation sensitivity. Oncogene 2003;22:5866-75.
-
(2003)
Oncogene
, vol.22
, pp. 5866-5875
-
-
McKenna, W.G.1
Muschel, R.J.2
Gupta, A.K.3
Hahn, S.M.4
Bernhard, E.J.5
-
43
-
-
0037838498
-
Signaling inhibition with radiation in colorectal cancer: Clinical trials
-
McKenna WG, Muschel RJ, Gupta A, Hahn S, Bernhard EJ. Signaling inhibition with radiation in colorectal cancer: clinical trials. Semin Oncol 2003;30:56-67.
-
(2003)
Semin. Oncol.
, vol.30
, pp. 56-67
-
-
McKenna, W.G.1
Muschel, R.J.2
Gupta, A.3
Hahn, S.4
Bernhard, E.J.5
-
44
-
-
0041353989
-
The MEK/ERK pathway acts upstream of NFκB1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apoptosis
-
Kurland JF, Voehringer DW, Meyn RE. The MEK/ERK pathway acts upstream of NFκB1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apoptosis. J Biol Chem 2003;278:32465-70.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32465-32470
-
-
Kurland, J.F.1
Voehringer, D.W.2
Meyn, R.E.3
|