Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic

Clinical Infectious Diseases

Volumn 39, Issue 8, 2004, Pages 1139-1147

  Mayxay, Mayfong ^a,b   Khanthavong, Maniphone ^c   Lindegårdh, Niklas ^f,g   Keola, Siamphay ^d   Barends, Marion ^g,h   Pongvongsa, Tiengkham ^e   Yapom, Ratsuda ^g,h   Annerberg, Anna ^g   Phompida, Samlane ^c   Phetsouvanh, Rattanaxay ^c   White, Nicholas J ^a,f,g,h   Newton, Paul N ^a,f,i  

^a Wellcome Trust Mahosot Hospital   (Laos)

^b NATIONAL UNIVERSITY OF LAOS   (Laos)

^c Ctr Malariology   (Laos)

^d Phalanxay District Clinic   (Laos)

^e Savannakhet Provincial Malaria Station   (Laos)

^f CHURCHILL HOSPITAL   (United Kingdom)

^g MAHIDOL UNIVERSITY   (Thailand)

^h SHOKLO MALARIA RESEARCH UNIT   (Thailand)

ⁱ MAHOSOT HOSPITAL   (Laos)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; CHLOROQUINE; FANSIDAR; MEFLOQUINE;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DIARRHEA; DIZZINESS; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; DYSPNEA; FAT INTAKE; FEMALE; FOLLOW UP; GAMETOCYTE; HEADACHE; HEART PALPITATION; HEMATOCRIT; HERPES LABIALIS; HUMAN; IRRITABILITY; LAOS; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MUSCLE WEAKNESS; NAUSEA AND VOMITING; NIGHTMARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REINFECTION; SCHOOL CHILD; TINNITUS; TREATMENT FAILURE; URTICARIA; VISUAL IMPAIRMENT;

ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; ETHANOLAMINES; FEMALE; FLUORENES; HUMANS; INFANT; LAOS; MALARIA, FALCIPARUM; MALE; MEFLOQUINE; PYRIMETHAMINE; SESQUITERPENES; SULFADOXINE;

EID: 19944433989     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/424512     Document Type: Article

References (33)

1. White NJ. Drug resistance in malaria. Br Med Bull 1998; 54:703-15.
2. Mayxay M, Phetsouvanh R, Phompida S, et al. A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Lao PDR (Laos) Trans R Soc Trop Med Hyg 2003; 97:343-4.
3. Mayxay M, Newton PN, Khanthavong M, et al. Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations. Clin Infect Dis 2003; 37:1021-8.
4. Pillai DR, Labbe AC, Vanisaveth V, et al. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. J Infect Dis 2001; 183:789-95.
5. Guthmann JP, Kasparian S, Nathan N, et al. The efficacy of chloroquine for the treatment of acute uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic. Ann Trop Med Parasitol 2002; 96:553-7.
6. Schwobel B, Jordan S, Vanisaveth V, et al. Therapeutic efficacy of chloroquine plus sulfadoxine/pyrimethamine compared with monotherapy with either chloroquine or pyrimethamine/sulfadoxine in uncomplicated Plasmodium falciparum malaria in Laos. Trop Med Int Health 2003; 8:19-24.
7. Adjuik M, Babiker A, Garner P, et al. Artesunate combinations for treatment of malaria. Lancet 2004; 363:9-17
8. van Vugt M, Brockman A, Gemperli B, et al. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria. Antimicrob Agents Chemother 1998; 42:135-9.
9. van Vugt M, Looareesuwan S, Wilairatana P, et al. Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria. Trans R Soc Trop Med Hyg 2000; 94:545-8.
10. Lefevre G, Looareesuwan S, Treeprasertsuk S, et al. A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 2001; 64:247-56.
11. Krudsood S, Looareesuwan S, Silachamroon U, et al. Artesunate and mefloquine given simultaneously for three days via a prepacked blister is equally effective and tolerated as a standard sequential treatment of uncomplicated acute Plasmodium falciparum malaria: randomized, double-blind study in Thailand. Am J Trop Med Hyg 2002; 67:465-72.
12. Krudsood S, Chalermrut K, Pengruksa C, et al. Comparative clinical trial of two fixed combinations dihydroartemisin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand. Southeast Asian J Trop Med Public Health 2003; 34:316-21.
13. Price R, van Vugt M, Phaipun L, et al. Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. Am J Trop Med Hyg 1999; 60:547-55.
14. van Vugt M, Wilairatana P, Gemperli B, et al. Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria. Am J Trop Med Hyg 1999; 60:936-42.
15. Poravuth Y, Socheat D, Fandeur T, et al. Efficacy and safety of six dose regimen of Coartem in the treatment of uncomplicated falciparum malaria in Cambodia 2002. Mekong Malaria Forum 2002; 10:54.
16. Bojang KA, Schneider G, Forck S, et al. A trial of Fansidar plus chloroquine or Fansidar alone for the treatment of uncomplicated malaria in Gambian children. Trans R Soc Trop Med Hyg 1998; 92:73-6.
17. Bustos DG, Canfield CJ, Canete-Miguel, Hutchinson BA. Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine- pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines. J Infect Dis 1999; 179:1587-90.
18. Gogtay NJ, Desai S, Kadam VS, Kamtekar KD, Dalvi SS, Kshirsagar NA. A randomized, parallel-group study in Mumbai (Bombay), comparing chloroquine with chloroquine plus sulfadoxine-pyrimethamine in the treatment of adults with acute, uncomplicated, Plasmodium falciparum malaria. Ann Trop Med Parasitol 2000; 94:309-12.
19. Gasasira AF, Gorsey G, Nzarubara B, et al. Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg 2003; 68:127-32.
20. McIntosh HM, Greenwood BM. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine as a treatment for uncomplicated malaria - a systematic review. Ann Trop Med Parasitol 1998; 92:265-70.
21. World Health Organization. Severe falciparum malaria. Trans R Soc Trop Med Hyg 2000; 94(Suppl 1):1-90.
22. Brockman A, Paul REL, Anderson TJC, et al. Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand. Am J Trop Med Hyg 1999; 60:14-21.
23. Silamut K, Hough R, Eggelte T, Pukrittayakamee S, Angus B, White NJ. A simple method for assessing quinine pretreatment in acute malaria. Trans R Soc Trop Med Hyg 1995; 89:665-7.
24. World Health Organization. Assessment and monitoring of antimalrial drug efficacy for the treatment of uncomplicated falciparum malaria. Document no. WHO/HTM/RBM2003.50. Geneva: World Health Organization, 2003.
25. World Health Organization. Chemotherapy of malaria and resistance to antimalarials: report of a WHO Scientific Working Group. World Health Organ Tech Rep Ser 1973; 529:1-121.
26. Food and Agriculture Organization. Food composition table. Available at: http://www.fao.org/DOCREP/003/X6878E/X6878E00.htm.Accessed 28 January 2004.
27. Ezzet F, van Vugt M, Nosten F, Looareesuwan S, White NJ. Pharmacokinetics and pharmacodynamics of lumefantrine (Benflumetol) in acute falciparum malaria. Antimicrob Agents Chemother 2000; 44:697-704.
28. Annerberg A, Lindegårdh N, Blessborn D, Bergqvist Y, White NJ. A bioanalytical method using automated solid-phase extraction and LC-UV for the simultaneous determination of lumefantrine and its desbutyl metabolite in plasma. Journal of Pharmaceutical and Biomedical Analysis (in press).
29. White NJ, van Vugt M, Ezzet F. Clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine. Clin Pharmacokinet 1999; 37:105-25.
30. Mayxay M, Chotivanich K, Pukrittayakamee S, Newton P, Looareesuwan S, White NJ. The contribution of humoral immunity to the therapeutic response in falciparum malaria. Am J Trop Med Hyg 2001; 65:918-23.
31. Price RN, Nosten F, Luxemburger C, et al. Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria. Trans R Soc Trop Med Hyg 1995; 89: 523-7.
32. Bakshi R, Hermeling-Fritz I, Gathmann I, Alteri E. An integrated assessment of the clinical safety of artemether-lumefantrine: a new oral fixed-dose combination antimalarial drug. Trans R Soc Trop Med Hyg 2000; 94:419-24.
33. Hugosson E, Tarimo D, Troye-Blomberg M, Montgomery SM, Premji Z, Bjorkman A. Antipyretic, parasitologic, and immunologic effects of combining sulfadoxine/pyrimethamine with chloroquine or paracetamol for treating uncomplicated Plasmodium falciparum malaria. Am J Trop Med Hyg 2003; 69:366-71.