A trial of Fansidar® plus chloroquine or Fansidar® alone for the treatment of uncomplicated malaria in Gambian children

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 92, Issue 1, 1998, Pages 73-76

  Bojang, K A ^a   Schneider, G ^b   Forck, S ^b   Obaro, S K ^a   Jaffar, S ^a,c   Pinder, M ^a   Rowley, J ^a   Greenwood, B M ^a,c  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b WEC Mission   (Gambia)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Chemotherapy; Children; Chloroquine; Fansidar ; Malaria; Plasmodium falciparum; The Gambia

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; FANSIDAR; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GAMBIA; HEMATOCRIT; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIAL; CHILD; DRUG COMBINATION; DRUG COST; ECONOMICS; INFANT; PARASITEMIA; PRESCHOOL CHILD; RECURRENT DISEASE; TREATMENT OUTCOME;

PLASMODIUM FALCIPARUM; PROTOZOA;

ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; DRUG COMBINATIONS; DRUG COSTS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; PARASITEMIA; PYRIMETHAMINE; RECURRENCE; SULFADOXINE; TREATMENT OUTCOME;

EID: 0031595850     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(98)90962-2     Document Type: Article

References (15)

1. Bloland, P. B., Lackritz, E. M., Kazembe, P. N., Were, J. B., Steketee, R. & Campbell, C. C. (1993). Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa. Journal of Infectious Diseases, 167, 932-937.
2. Boele van Hensbroek, M., Morris-Jones, S., Meisner, S., Jaffar, S., Bayo, L., Dackour, R., Phillips, C. & Greenwood, B. M. (1995). Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 672-676.
3. Brewster, D. R. & Greenwood, B. M. (1993). Seasonal variations of paediatric disease in The Gambia, West Africa. Annals of Tropical Paediatrics, 13, 133-146.
4. Greenwood, B. M. & Armstrong, J. R. M. (1991). Comparison of two simple methods for determining malaria parasite density. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85, 186-188.
5. Greenwood, B. M., Bradley, A. K., Greenwood, A. M., Byass, P., Jammeh, K., Marsh, K., Tulloch, S., Oldfield, P. S. J. & Hayes, R. (1987). Mortality and morbidity from malaria among children in a rural area of The Gambia, West Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 81, 478-486.
6. Keuter, M., Sanders, J., Ronday, M., Veltkamp, S., Kamsteeg, H., Schouten, E., Kalumi, G., Ngwawe, W., Wetsteyn, J. C. F. M., de Geus, A. & Brandling-Bennett, A. D. (1992). Parasitological, clinical, and haematological response of children with Plasmodium falciparum to 4-aminoquinolines and to pyrimethamine-sulfadoxine with quinine in western Kenya. Tropical and Geographical Medicine, 44, 1-8.
7. Krishna, S., Pukrittayakamee, S., Supanaranond, W., ter Kuile, F., Ruprah, M., Sura, T. & White, N. J. (1995). Fever in uncomplicated Plasmodium falciparum malaria: randomized double-'blind' comparison of ibuprofen and paracetamol treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 507-509.
8. Kwiatkowski, D. & Bates, B. (1995). Inhibition of tumour necrosis factor (TNF) production by antimalarial drugs used in cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 215-216.
9. Kwiatkowski, D., Molyneux, M. E., Stephens, S., Curtis, N., Klein, N., Pointaire, P., Smit, M., Allan, R., Brewster, D. R., Gau, G. E. & Greenwood, B. M. (1993). Anti-TNF therapy inhibits fever in cerebral malaria. Quarterly Journal of Medicine, 86, 91-98.
10. Menon, A., Snow, R. W., Otoo, L. & Greenwood, B. M. (1987). Decline in sensitivity of Plasmodium falciparum in The Gambia. Lancet, ii, 1029-1030.
11. Menon, A., Otoo, L. N., Herbage, E. A. & Greenwood, B. M. (1990). A national survey of the prevalence of chloroquine-resistant Plasmodium falciparum malaria in The Gambia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, 638-640.
12. Müller, O., Boele van Hensbroek, M., Jaffar, S., Drakeley, C., Okorie, C., Joof, D., Pinder, M. & Greenwood, B. (1996). A randomized trial of chloroquine, amodiaquine and pyrimethamine-sulphadoxine in Gambian children with uncomplicated malaria. Tropical Medicine and International Health, 1, 124-132.
13. Onyiorah, E., Boele van Hensbroek, M., Jah, M. S. & Greenwood, B. (1996). Early clinical failures after pyrimethamine-sulfadoxine treatment of uncomplicated falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 307-308.
14. Picot, S., Peyron, F., Vuillez, M.-P., Polack, B. & Ambroise-Thomas, P. (1991). Chloroquine inhibits tumour necrosis factor production by human macrophages in vivo. Journal of Infectious Diseases, 164, 830.
15. Picot, S., Peyron, F., Dolnadille, A., Vuillez, M.-P., Barbe, G. & Ambroise-Thomas, P. (1993). Chloroquine induced inhibition of the production of TNF, but not of IL-6, is affected by disruption of iron metabolism. Immunology, 80, 127-133.