Atovaquone-proguanil compared with chloroquine and chloroquine- sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines

Journal of Infectious Diseases

Volumn 179, Issue 6, 1999, Pages 1587-1590

  Bustos, Dorina G ^a,b,c,d,e   Canfield, Craig J ^a,b,c,d,e   Canete Miguel, Editha ^a,b,c,d,e   Hutchinson, David B A ^a,b,c,d,e  

^a RESEARCH INSTITUTE FOR TROPICAL MEDICINE   (Philippines)

^b Palawan Provincial Hospital   (Philippines)

^c Pharmaceutical Systems Inc   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

^e GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE; ATOVAQUONE PLUS PROGUANIL; CHLOROQUINE; PROGUANIL; PYRIMETHAMINE; SULFADOXINE;

ABDOMINAL PAIN; ANOREXIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MIXTURE; DRUG TOLERABILITY; FEVER; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MULTIDRUG RESISTANCE; ORAL DRUG ADMINISTRATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOMITING;

ANTIMALARIALS; ATOVAQUONE; CHLOROGUANIDE; CHLOROQUINE; DRUG THERAPY, COMBINATION; FOLIC ACID ANTAGONISTS; HUMANS; MALARIA, FALCIPARUM; NAPHTHOQUINONES; PHILIPPINES; PYRIMETHAMINE; SULFADOXINE;

EID: 0033060696     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314770     Document Type: Article

References (15)

1. 1. White NJ. The treatment of malaria. N Engl J Med 1996;335:800-6.
2. 2. Anonymous. World malaria situation in 1994. Weekly Epidemiol Red 1997;72:269-74.
3. 3. Shute GT, Ray AP, Sangalang RP. Preliminary studies on a Philippine strain of Plasmodium falciparum resistant to amodiaquine. J Trop Med Hyg 1970;75:125-32.
4. 4. Baird JK, Caneta-Miguel E, Masbar S, et al. Survey of resistance to chloroquine of falciparum and vivax malaria in Palawan, the Philippines. Trans R Soc Trop Med Hyg 1996;90:413-4.
5. 5. Fry M, Pudney M. Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4′-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80). Biochem Pharmacol 1992;43:1545-53.
6. 6. Dollery C, ed. Proguanil (hydrochloride). Therapeutic Drugs, Vol. 2. New York: Churchill Livingston, 1991; 247-51.
7. 7. Canfield CJ, Pudney M, Gutteridge WE. Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp Parasitol 1995;80:373-81.
8. 8. Looareesuwan S, Viravan C, Webster HK, Kyle DE, Hutchinson DB, Canfield CJ. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am J Trop Med Hyg 1996;54:62-6.
9. 9. Radloff PD, Philipps J, Nkeyi M, Hutchinson D, Kremsner PG. Atovaquone and proguanil for Plasmodium falciparum malaria. Lancet 1996;347: 1511-4.
10. 10. Looareesuwan S, Wilairatana P, Chalermarut K, Rattanapong Y, Canfield CJ, Hutchinson DBA. Efficacy and safety of atovaquone/proguanil compared with mefloquine for treatment of acute Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 1999;60:526-32.
11. 11. de Alencar FEC, Cerutti C Jr, Durlacher RR, et al. Atovaquone and proguanil for the treatment of malaria in Brazil. J Infect Dis 1997;175:1544-7.
12. 12. Looareesuwan S, Chulay JD, Canfield CJ, Hutchinson DB. Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Am J Trop Med Hyg 1999;533-41.
13. 13. World Health Organization. Advances in malaria chemotherapy. WHO Tech Rep Ser 1973;529:30.
14. 14. Desjardins RE, Canfield CJ, Haynes JD, Chulay JD. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother 1979;16:710-8.
15. 15. Gachot B, Houze S, LeBras J, Charmot G, Bédos JP, Vachon F. Possible prognostic significance of a brief rise in parasitaemia following quinine treatment of severe Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 1996;90:388-90.