Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria

American Journal of Tropical Medicine and Hygiene

Volumn 60, Issue 6, 1999, Pages 936-942

  Van Vugt, M ^a   Wilairatana, P ^b   Gemperli, B ^c   Gathmann, I ^c   Phaipun, L ^a   Brockman, A ^a   Luxemburger, C ^a   White, N J ^b   Nosten, F ^a   Looareesuwan, S ^b  

^a SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; MEFLOQUINE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; MALARIA; MULTIDRUG RESISTANCE; ORAL DRUG ADMINISTRATION; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIAL; THAILAND; TREATMENT OUTCOME;

EID: 0033027432     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1999.60.936     Document Type: Article

References (14)

1. White NJ, 1992. Antimalarial drug resistance: the pace quickens. J Antimicrob Chemother 30: 571-585.
2. Looareesuwan S, Viravan C, Vanijanonta S, Wilairatana P, Suntharasamai P, Charoenlarp P, Arnold K, Kyle D, Canfield C, Webster K, 1992. Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria. Lancet 339: 821-824.
3. Nosten F, Luxemburger C, ter Kuile FO, Woodrow C, Pa Eh J, Chongsuphajaisiddhi T, White NJ, 1994. Treatment of multi drug resistant Plasmodium falciparum malaria with a 3 day artesunate-mefloquine combination. J Infect Dis 170: 971-977.
4. Price RN, Nosten F, Luxemburger C, Am Kham, Brockman A, Chongsuphajaisiddhi T, White NJ, 1995. Artesunate versus artemether in combination with mefloquine for the treatment of multidrug resistant falciparum malaria. Trans R Soc Trop Med Hyg 89: 523-527.
5. van Vugt M, Brockman A, Gemperli B, Luxemburger C, Gathmann I, Royce C, Thra Slight, Looareesuwan S, White NJ, Nosten F, 1998. A randomised comparison of artemether-benflumetol and artesunate-mefloquine in the treatment of multidrug resistant falciparum malaria. Antimicrob Agents Chemother 42: 135-139.
6. World Health Organization, 1990. Control of Tropical Diseases. Severe and complicated malaria. Trans R Soc Trop Med Hyg 80 (suppl 2): 1-85.
7. Webster HK, Boudreau EF, Pavanand K, Yongvanitchit K, Pang LW, 1985. Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand. Am J Trop Med Hyg 34: 228-235.
8. Hatz C, Abdulla S, Mull R, Schellenberg D, Gathmann I, Kibatala P, Beck H-P, Tanner M, Royce C, 1998. Efficiacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged 1-5 years. Trop Med Int Health 3: 495-504.
9. von Seidlein L, Jaffar S, Pinder M, Haywood M, Snounou G, Gemperli B, Gathmann I, Royce C, Greenwood B, 1997. Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697. J Infect Dis 176: 1113-1116.
10. White NJ, 1994. Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Trans R Soc Trop Med Hyg 88 (suppl 1): 41-43.
11. White NJ, 1997. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agents Chemother 41: 1413-1422.
12. Ezzet F, Mull R, Karbwang J, 1998. Population pharmacokinetics and therapeutic response of CGP 566 97 (artemether and benflumetol) in malaria patients. Br J Clin Pharmacol 46: 553-562.
13. White NJ, 1998. Preventing antimalarial drug resistance through combinations. Drug Resistance Updates 1: 3-9.
14. Price RN, Nosten F, Luxemburger C, ter Kuile FO, Paiphun L, Chongsuphajaisiddhi T, White NJ, 1996. The effects of artemisinin derivatives on malaria transmissability. Lancet 347: 1654-1658.