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Volumn 65, Issue 2, 2005, Pages 546-552

Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: Significance of timing of 5-fluorouracil administration

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; FLUOROURACIL; PROTEIN AXE1CAUP; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; URACIL PHOSPHORIBOSYLTRANSFERASE;

EID: 19944431439     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (20)

References (48)
  • 2
    • 0032535652 scopus 로고    scopus 로고
    • The National Cancer Data Base Report on Carcinoma of the Gallbladder, 1989-1995
    • Donohue JH, Stewart AK, Menck HR. The National Cancer Data Base Report on Carcinoma of the Gallbladder, 1989-1995. Cancer 1998;83:2618-28.
    • (1998) Cancer , vol.83 , pp. 2618-2628
    • Donohue, J.H.1    Stewart, A.K.2    Menck, H.R.3
  • 3
    • 0035060829 scopus 로고    scopus 로고
    • Prognostic factors and long-term results after surgery for gallbladder carcinoma: A retrospective study of 127 patients
    • Schauer RJ, Meyer G, Baretton G, Schildberg FW, Rau HG. Prognostic factors and long-term results after surgery for gallbladder carcinoma: a retrospective study of 127 patients. Langenbecks Arch Surg 2001;386:110-7.
    • (2001) Langenbecks Arch Surg , vol.386 , pp. 110-117
    • Schauer, R.J.1    Meyer, G.2    Baretton, G.3    Schildberg, F.W.4    Rau, H.G.5
  • 4
    • 0026666040 scopus 로고
    • Carcinoma of the extrahepatic bile duct
    • Henson DE, Saavedra JA, Corle D. Carcinoma of the extrahepatic bile duct. Cancer 1992;70:1498-501.
    • (1992) Cancer , vol.70 , pp. 1498-1501
    • Henson, D.E.1    Saavedra, J.A.2    Corle, D.3
  • 5
    • 0034980707 scopus 로고    scopus 로고
    • Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters
    • Nakano K, Todo T, Chijiiwa K, Tanaka M. Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters. Mol Ther 2001;3:431-7.
    • (2001) Mol Ther , vol.3 , pp. 431-437
    • Nakano, K.1    Todo, T.2    Chijiiwa, K.3    Tanaka, M.4
  • 6
    • 0024164649 scopus 로고
    • Fluorouracil: Biochemistry and pharmacology
    • Pinedo HM, Peters GFJ. Fluorouracil: biochemistry and pharmacology. J Clin Oncol 1988;6:1653-64.
    • (1988) J Clin Oncol , vol.6 , pp. 1653-1664
    • Pinedo, H.M.1    Peters, G.F.J.2
  • 7
    • 0032080867 scopus 로고    scopus 로고
    • Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil
    • Kanai F, Kawakami T, Hamada H, et al. Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil. Cancer Res 1998;58:1946-51.
    • (1998) Cancer Res , vol.58 , pp. 1946-1951
    • Kanai, F.1    Kawakami, T.2    Hamada, H.3
  • 8
    • 0033696046 scopus 로고    scopus 로고
    • Adenoviral-mediated transfer of Escherichia coli uracil phosphoribosyltransferase (UPRT) gene to modulate the sensitivity of human colon cancer cells to 5-fluorouracil
    • Koyama F, Sawada H, Fuji H, et al. Adenoviral-mediated transfer of Escherichia coli uracil phosphoribosyltransferase (UPRT) gene to modulate the sensitivity of human colon cancer cells to 5-fluorouracil. Eur J Cancer 2000;36:2403-10.
    • (2000) Eur J Cancer , vol.36 , pp. 2403-2410
    • Koyama, F.1    Sawada, H.2    Fuji, H.3
  • 9
    • 0034087221 scopus 로고    scopus 로고
    • Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity
    • Kawamura K, Tasaki K, Hamada H, Takenaga K, Sakiyama S, Tagawa M. Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity. Cancer Gene Ther 2000;7:637-43.
    • (2000) Cancer Gene Ther , vol.7 , pp. 637-643
    • Kawamura, K.1    Tasaki, K.2    Hamada, H.3    Takenaga, K.4    Sakiyama, S.5    Tagawa, M.6
  • 10
    • 0030928619 scopus 로고    scopus 로고
    • Gene therapy: Promises, problems and prospects
    • Verma IM, Somia N. Gene therapy: promises, problems and prospects. Nature 1997;389:239-42.
    • (1997) Nature , vol.389 , pp. 239-242
    • Verma, I.M.1    Somia, N.2
  • 11
    • 0034022622 scopus 로고    scopus 로고
    • Gene delivery from replication-selective viruses: Arming guided missiles in the war against cancer
    • Hermiston T. Gene delivery from replication-selective viruses: arming guided missiles in the war against cancer. J Clin Invest 2000;105:1169-72.
    • (2000) J Clin Invest , vol.105 , pp. 1169-1172
    • Hermiston, T.1
  • 12
    • 0033817601 scopus 로고    scopus 로고
    • The development of conditionally replicative adenovirus for cancer therapy
    • Alemany M, Curiel DT. The development of conditionally replicative adenovirus for cancer therapy. Clin Cancer Res 2000;6:3395-9.
    • (2000) Clin Cancer Res , vol.6 , pp. 3395-3399
    • Alemany, M.1    Curiel, D.T.2
  • 13
    • 0034722892 scopus 로고    scopus 로고
    • Replication-selective oncolytic adenoviruses: Virotherapy aimed at genetic targets in cancer
    • Kirn D. Replication-selective oncolytic adenoviruses: virotherapy aimed at genetic targets in cancer. Oncogene 2000;19:6660-9.
    • (2000) Oncogene , vol.19 , pp. 6660-6669
    • Kirn, D.1
  • 14
    • 0037033736 scopus 로고    scopus 로고
    • ONYX-015: Mechanism of action and clinical potential of a replication-selective adenovirus
    • Ries S, Korn WM. ONYX-015: mechanism of action and clinical potential of a replication-selective adenovirus. Br J Cancer 2002;86:5-11.
    • (2002) Br J Cancer , vol.86 , pp. 5-11
    • Ries, S.1    Korn, W.M.2
  • 15
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-lacking human tumor cells
    • Bishoff JR, Kirn DH, Williams A, et al. An adenovirus mutant that replicates selectively in p53-lacking human tumor cells. Science 1996;274:373-6.
    • (1996) Science , vol.274 , pp. 373-376
    • Bishoff, J.R.1    Kirn, D.H.2    Williams, A.3
  • 16
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise C, Jhoannes AS, Williams A, McCormick F, Hoff DDV, Kirn DH. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 1997;3:639-45.
    • (1997) Nat Med , vol.3 , pp. 639-645
    • Heise, C.1    Jhoannes, A.S.2    Williams, A.3    McCormick, F.4    Hoff, D.D.V.5    Kirn, D.H.6
  • 17
    • 0033831080 scopus 로고    scopus 로고
    • A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
    • Khuri FR, Nemunaitis J, Ganly I, et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med 2000;6:879-85.
    • (2000) Nat Med , vol.6 , pp. 879-885
    • Khuri, F.R.1    Nemunaitis, J.2    Ganly, I.3
  • 18
    • 0041589480 scopus 로고    scopus 로고
    • E1A, E1B Double-Restricted oncolytic adenovirus for gene therapy of gallbladder cancer
    • Fukuda K, Abei M, Ugai H, et al. E1A, E1B Double-Restricted oncolytic adenovirus for gene therapy of gallbladder cancer. Cancer Res 2003;63:4434-40.
    • (2003) Cancer Res , vol.63 , pp. 4434-4440
    • Fukuda, K.1    Abei, M.2    Ugai, H.3
  • 19
    • 0027253687 scopus 로고
    • p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gallbladder
    • Kamel D, Paakko P, Nuorva K, Vahakangas K, Soini Y. p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gallbladder. J Pathol 1993;170:67-72.
    • (1993) J Pathol , vol.170 , pp. 67-72
    • Kamel, D.1    Paakko, P.2    Nuorva, K.3    Vahakangas, K.4    Soini, Y.5
  • 20
    • 0030028136 scopus 로고    scopus 로고
    • K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct
    • Hanada K, Itoh M, Fujii K, Tsuchida A, Ooishi H, Kajiyama G. K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct. Cancer 1996;77:452-8.
    • (1996) Cancer , vol.77 , pp. 452-458
    • Hanada, K.1    Itoh, M.2    Fujii, K.3    Tsuchida, A.4    Ooishi, H.5    Kajiyama, G.6
  • 21
    • 0036466856 scopus 로고    scopus 로고
    • Inactivation of the INK4A/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines
    • Caca K, Feisthammel J, Klee K, et al. Inactivation of the INK4A/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines. Int J Cancer 2002;97:481-8.
    • (2002) Int J Cancer , vol.97 , pp. 481-488
    • Caca, K.1    Feisthammel, J.2    Klee, K.3
  • 22
    • 0028981089 scopus 로고
    • Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 gene in biliary tract cancers
    • Yoshida S, Todoroki T, Ichikawa Y. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 gene in biliary tract cancers. Cancer Res 1995;55:2756-60.
    • (1995) Cancer Res , vol.55 , pp. 2756-2760
    • Yoshida, S.1    Todoroki, T.2    Ichikawa, Y.3
  • 23
    • 0033761385 scopus 로고    scopus 로고
    • Overexpression of retinoblastoma protein predicts decreased survival and correlates with loss of p16INK4 protein in gallbladder carcinomas
    • Shi YZ, Hui AM, Li X, Takayama T, Makuuchi M. Overexpression of retinoblastoma protein predicts decreased survival and correlates with loss of p16INK4 protein in gallbladder carcinomas. Clin Cancer Res 2000;6:4096-100.
    • (2000) Clin Cancer Res , vol.6 , pp. 4096-4100
    • Shi, Y.Z.1    Hui, A.M.2    Li, X.3    Takayama, T.4    Makuuchi, M.5
  • 24
    • 0032503659 scopus 로고    scopus 로고
    • A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy
    • Freytag SO, Rogulski KR, Paielli DL, Gilbert JD, Kim JH. A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy. Hum Gene Ther 1998;9:1323-33.
    • (1998) Hum Gene Ther , vol.9 , pp. 1323-1333
    • Freytag, S.O.1    Rogulski, K.R.2    Paielli, D.L.3    Gilbert, J.D.4    Kim, J.H.5
  • 25
    • 0033984339 scopus 로고    scopus 로고
    • Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radio-sensitization
    • Rogulski KR, Wing MS, Paielli DL, Gilbert JD, Kim JH, Freytag SO. Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radio-sensitization. Hum Gene Ther 2000;11:67-76.
    • (2000) Hum Gene Ther , vol.11 , pp. 67-76
    • Rogulski, K.R.1    Wing, M.S.2    Paielli, D.L.3    Gilbert, J.D.4    Kim, J.H.5    Freytag, S.O.6
  • 26
    • 0033556003 scopus 로고    scopus 로고
    • Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase
    • Wildner O, Blaese RM, Morris JC. Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase. Cancer Res 1999;59:410-3.
    • (1999) Cancer Res , vol.59 , pp. 410-413
    • Wildner, O.1    Blaese, R.M.2    Morris, J.C.3
  • 27
    • 0032922211 scopus 로고    scopus 로고
    • Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer
    • Wildner O, Morris JC, Vahanian NN, Ford H Jr, Ramsey WJ, Blaese RM. Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer. Gene Ther 1999;6:57-62.
    • (1999) Gene Ther , vol.6 , pp. 57-62
    • Wildner, O.1    Morris, J.C.2    Vahanian, N.N.3    Ford Jr., H.4    Ramsey, W.J.5    Blaese, R.M.6
  • 28
    • 0033643594 scopus 로고    scopus 로고
    • Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tk
    • Morris JC, Wildner O. Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tk. Mol Ther 2000;1:56-62.
    • (2000) Mol Ther , vol.1 , pp. 56-62
    • Morris, J.C.1    Wildner, O.2
  • 29
    • 0033895515 scopus 로고    scopus 로고
    • The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: Assessment of antitumor efficacy and toxicity
    • Wildner O, Morris JC. The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: assessment of antitumor efficacy and toxicity. Cancer Res 2000;60:4167-74.
    • (2000) Cancer Res , vol.60 , pp. 4167-4174
    • Wildner, O.1    Morris, J.C.2
  • 30
    • 0034956825 scopus 로고    scopus 로고
    • Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy
    • Lambright ES, Amin K, Wiewrodt R, et al. Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy. Gene Ther 2001;8:946-53.
    • (2001) Gene Ther , vol.8 , pp. 946-953
    • Lambright, E.S.1    Amin, K.2    Wiewrodt, R.3
  • 31
    • 0035893397 scopus 로고    scopus 로고
    • Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase
    • Nanda D, Vogels R, Havenga M, Avezaat CJ, Bout A, Smitt PS. Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase. Cancer Res 2001;63:8743-50.
    • (2001) Cancer Res , vol.63 , pp. 8743-8750
    • Nanda, D.1    Vogels, R.2    Havenga, M.3    Avezaat, C.J.4    Bout, A.5    Smitt, P.S.6
  • 32
    • 4544295901 scopus 로고    scopus 로고
    • Establishment and characterization of unique human gallbladder cancer cell lines
    • Ghosh M, Koike N, Yanagimoto G, et al. Establishment and characterization of unique human gallbladder cancer cell lines. Int J Oncol 2004;24:1189-96.
    • (2004) Int J Oncol , vol.24 , pp. 1189-1196
    • Ghosh, M.1    Koike, N.2    Yanagimoto, G.3
  • 33
    • 0021874928 scopus 로고
    • Biliary adenocarcinoma. Characterisation of three new human tumor cell lines
    • Knuth A, Gabbert H, Dippold W, et al. Biliary adenocarcinoma. Characterisation of three new human tumor cell lines. J Hepatol 1985;1:579-96.
    • (1985) J Hepatol , vol.1 , pp. 579-596
    • Knuth, A.1    Gabbert, H.2    Dippold, W.3
  • 34
    • 0028799961 scopus 로고
    • Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
    • Kanegae Y, Lee G, Sato Y, et al. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res 1995;23:3816-21.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3816-3821
    • Kanegae, Y.1    Lee, G.2    Sato, Y.3
  • 35
    • 0034688181 scopus 로고    scopus 로고
    • Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus
    • Motoi F, Sunamura M, Ding L, et al. Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus. Hum Gene Ther 2000;11:223-35.
    • (2000) Hum Gene Ther , vol.11 , pp. 223-235
    • Motoi, F.1    Sunamura, M.2    Ding, L.3
  • 36
    • 0030070724 scopus 로고    scopus 로고
    • Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full length virus genome
    • Miyake S, Makimura M, Kanegae Y, et al. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full length virus genome. Proc Natl Acad Sci U S A 1996;93:1320-4.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 1320-1324
    • Miyake, S.1    Makimura, M.2    Kanegae, Y.3
  • 37
    • 0000965308 scopus 로고
    • Determination of 5-fluorouracil incorporation into RNA in tissue using gas chromatography-mass spectrometry
    • Masuike T, Kikuchi K, Saito A, Hashimoto T, Takemoto Y. Determination of 5-fluorouracil incorporation into RNA in tissue using gas chromatography-mass spectrometry. Antibiot Chemother 1995;11:162-7.
    • (1995) Antibiot Chemother , vol.11 , pp. 162-167
    • Masuike, T.1    Kikuchi, K.2    Saito, A.3    Hashimoto, T.4    Takemoto, Y.5
  • 38
    • 0035878715 scopus 로고    scopus 로고
    • Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that express yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil
    • Nakamura H, Mullen JT, Chandrasekhar S, Pwlik TK, Yoon SS, Tanabe KK. Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that express yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil. Cancer Res 2001;61:5447-52.
    • (2001) Cancer Res , vol.61 , pp. 5447-5452
    • Nakamura, H.1    Mullen, J.T.2    Chandrasekhar, S.3    Pwlik, T.K.4    Yoon, S.S.5    Tanabe, K.K.6
  • 39
    • 0344200002 scopus 로고    scopus 로고
    • Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies
    • Ahgi M, Chou TC, Suling K, Breakefield XO, Chiocca EA. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res 1999;59:3861-5.
    • (1999) Cancer Res , vol.59 , pp. 3861-3865
    • Ahgi, M.1    Chou, T.C.2    Suling, K.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 40
    • 0033918250 scopus 로고    scopus 로고
    • Evaluation of ganciclovir-mediated enhancement of the oncolytic effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors
    • Todo T, Rabkin SD, Martuza RL. Evaluation of ganciclovir-mediated enhancement of the oncolytic effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors. Cancer Gene Ther 2000;7:939-46.
    • (2000) Cancer Gene Ther , vol.7 , pp. 939-946
    • Todo, T.1    Rabkin, S.D.2    Martuza, R.L.3
  • 41
    • 0031148328 scopus 로고    scopus 로고
    • The effect of ganciclovir on herpes simplex virus-mediated oncolysis
    • Carroll NM, Chase M, Chiocca EA. The effect of ganciclovir on herpes simplex virus-mediated oncolysis. J Surg Res 1997;69:413-7.
    • (1997) J Surg Res , vol.69 , pp. 413-417
    • Carroll, N.M.1    Chase, M.2    Chiocca, E.A.3
  • 42
    • 0036733759 scopus 로고    scopus 로고
    • Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
    • Freytag SO, Khil M, Stricker H, et al. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res 2002;62:4968-76.
    • (2002) Cancer Res , vol.62 , pp. 4968-4976
    • Freytag, S.O.1    Khil, M.2    Stricker, H.3
  • 43
    • 0036885116 scopus 로고    scopus 로고
    • Oncolytic viruses
    • Chiocca EA. Oncolytic viruses. Nat Rev Cancer 2002;2:938-50.
    • (2002) Nat Rev Cancer , vol.2 , pp. 938-950
    • Chiocca, E.A.1
  • 45
    • 0035300468 scopus 로고    scopus 로고
    • Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo
    • Jacobs A, Tjuvajev JG, Dubrovin M, et al. Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res 2001;61:2983-95.
    • (2001) Cancer Res , vol.61 , pp. 2983-2995
    • Jacobs, A.1    Tjuvajev, J.G.2    Dubrovin, M.3
  • 46
    • 0036100536 scopus 로고    scopus 로고
    • Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides
    • Peng KW, Facteau S, Wegman T, O'Kane D, Russel SJ. Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides. Nat Med 2002;8:527-31.
    • (2002) Nat Med , vol.8 , pp. 527-531
    • Peng, K.W.1    Facteau, S.2    Wegman, T.3    O'Kane, D.4    Russel, S.J.5
  • 47
    • 0036827801 scopus 로고    scopus 로고
    • Enzyme-activated prodrug therapy enhances tumor-specific replication of adenovirus vectors
    • Bernt KM, Steinwaerder DS, Ni S, Li Z-Y, Roffler SR, Lieber A. Enzyme-activated prodrug therapy enhances tumor-specific replication of adenovirus vectors. Cancer Res 2002;62:6089-98.
    • (2002) Cancer Res , vol.62 , pp. 6089-6098
    • Bernt, K.M.1    Steinwaerder, D.S.2    Ni, S.3    Li, Z.-Y.4    Roffler, S.R.5    Lieber, A.6
  • 48
    • 0036837479 scopus 로고    scopus 로고
    • Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosyltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors
    • Oonuma M, Sunamura M, Motoi F, et al. Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosyltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors. Int J Cancer 2002;102:51-9.
    • (2002) Int J Cancer , vol.102 , pp. 51-59
    • Oonuma, M.1    Sunamura, M.2    Motoi, F.3


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