Overexpression of retinoblastoma protein predicts decreased survival and correlates with loss of p16(INK4) protein in gallbladder carcinomas

Clinical Cancer Research

Volumn 6, Issue 10, 2000, Pages 4096-4100

  Shi, Y Z ^a   Hui, A M ^a   Li, X ^a   Takayama, T ^a   Makuuchi, M ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; GALLBLADDER CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR GROWTH;

AGED; AGED, 80 AND OVER; CARCINOMA; CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EPITHELIUM; FEMALE; GALLBLADDER; GALLBLADDER NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; RETINOBLASTOMA PROTEIN; TIME FACTORS;

EID: 0033761385     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Tumor suppressor genes
2. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
3. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
4. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
5. Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
6. Expression of p16 induces transcriptional downregulation of the RB gene
7. K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct
8. K-ras gene mutation in gall bladder carcinomas and dysplasia
9. p53 Protein expression and prognosis in gallbladder carcinoma and premalignant lesions
10. Overexpression and lack of retinoblastoma protein are associated with tumor progression and metastasis in hepatocellular carcinoma
11. Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer
12. Expression of the retinoblastoma protein is regulated in normal human tissues
13. p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
14. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells
15. Mutation spectrum of the retinoblastoma gene in osteosarcomas
16. Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer
17. Tumor suppressor genes
18. Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression
19. Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile
20. Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53
21. 1 bladder cancer
22. Wild-type and mutant retinoblastoma protein in paraffin sections
23. 1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
24. 1
25. The retinoblastoma protein and cell cycle control
26. 1 phase progression: Cycling on cue
27. p21 Is a universal inhibitor of cyclin kinases
28. p27, A novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
29. p57(KIP2), a structurally distinct member of the p21(CIP1) Cdk inhibitor family, is a candidate tumor suppressor gene
30. Loss of p16(INK4) protein, alone and together with loss of retinoblastoma protein, correlate with hepatocellular carcinoma progression