Serum leptin level and the risk of nontraumatic fracture

American Journal of Medicine

Volumn 117, Issue 12, 2004, Pages 952-956

  Schett, Georg ^a   Kiechl, Stefan ^b   Bonora, Enzo ^c   Redlich, Kurt ^a   Woloszczuk, Wolfgang ^d   Oberhollenzer, Friedrich ^e   Jocher, Josef ^e   Dorizzi, Romolo ^c   Muggeo, Michele ^c   Smolen, Josef ^a   Willeit, Johann ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^c UNIVERSITY OF VERONA   (Italy)

^d LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^e BRUNECK HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RISK ASSESSMENT;

AGED; BIOLOGICAL MARKERS; BODY WEIGHT; BONE REMODELING; COLLAGEN; FEMALE; FRACTURES, BONE; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; MIDDLE AGED; OSTEOCALCIN; PEPTIDE FRAGMENTS; REGRESSION ANALYSIS; RISK ASSESSMENT;

EID: 19944429034     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2004.07.044     Document Type: Article

References (38)

1. R.S. Ahima, J.S. Flier Leptin Ann Rev Physiol 62 2000 413 437
2. T.A. Cock, J. Auwers Leptin cutting the fat off the bone Lancet 362 2003 1572 1574
3. J. Cornish, K.E. Callon, U. Bava Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo J Endocrinol 175 2002 405 415
4. B. Burguera, L.C. Hofbauer, T. Thomas Leptin reduces ovariectomy-induced bone loss in rats Endocrinology 142 2001 3546 3553
5. W.R. Holloway, F.M. Collier, C.J. Aitken Leptin inhibits osteoclast generation J Bone Miner Res 17 2002 200 209
6. T. Thomas, F. Gori, S. Khosla Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes Endocrinology 140 1999 1630 1638
7. J.E. Reseland, U. Syversen, I. Bakke Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization J Bone Miner Res 16 2001 1426 1433
8. J. Foldes, M.S. Shih, J. Levy Bone structure and calcium metabolism in obese Zucker rats Int J Obes Relat Metab Disord 16 1992 95 102
9. C. Picherit, M.N. Horcajada, J. Mathey Isoflavone consumption does not increase the bone mass in osteopenic obese female zucker rats Ann Nutr Metab 47 2003 70 77
10. J.A. Tamasi, B.J. Arey, D.R. Bertolini, J.H. Feyen Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats J Bone Miner Res 18 2003 1605 1611
11. P. Ducy, M. Amling, S. Takeda Leptin inhibits bone formation through a hypothalamic relay a central control of bone mass Cell 100 2000 197 207
12. S. Takeda, F. Elefteriou, R. Levasseur Leptin regulates bone formation via the sympathetic nervous system Cell 111 2002 305 317
13. A. Matsunuma, T. Kawane, T. Maeda Leptin corrects increased gene expression of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase and -24-hydroxylase in leptin-deficient, ob/ob mice Endocrinology 14 2004 1367 1375
14. M. Yamauchi, T. Sugimoto, T. Yamaguchi Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women Clin Endocrinol 55 2001 341 347
15. H. Blain, A. Vullemin, F. Guillemin Serum leptin level is a predictor of bone mineral density in postmenopausal women J Clin Endocrinol Metab 87 2002 1030 1035
16. E. Zoico, M. Zamboni, S. Adami Relationship between leptin levels and bone mineral density in the elderly Clin Endocrinol 59 2003 97 103
17. C. Roux, A. Arabi, R. Porcher, P. Garnero Serum leptin as a determinant of bone resorption in healthy postmenopausal women Bone 33 2003 847 852
18. A. Goulding, R.W. Taylor Plasma leptin values in relation to bone mass and density and to dynamic biochemical markers of bone resorption and formation in postmenopausal women Calcif Tissue Int 63 1998 456 458
19. J.A. Pasco, M.J. Henry, M.A. Kotowicz Serum leptin levels are associated with bone mass in nonobese women J Clin Endocrinol Metab 86 2001 1884 1887
20. E. Odabasi, M. Ozata, M. Turan Plasma leptin concentrations in postmenopausal women with osteoporosis Eur J Endocrinol 142 2000 170 173
21. T. Thomas, B. Burguera, L.J. Melton III Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women Bone 29 2001 114 120
22. G. Martini, R. Valenti, S. Giovani Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women Bone 28 2001 113 117
23. F. Rauch, W.F. Blum, K. Klein Does leptin have an effect on bone in adult women? Calcif Tissue Int 63 1998 453 455
24. M. Sato, N. Takeda, H. Sarui Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men J Clin Endocrinol Metab 86 2001 5273 5276
25. C.E. Ruhl, J.E. Everhart Relationship of serum leptin concentration with bone mineral density in the United States population J Bone Miner Res 17 2002 1896 1903
26. M. Blum, S.S. Harris, A. Must Leptin, body composition and bone mineral density in premenopausal women Calcif Tissue Int 73 2003 27 32
27. S. Kiechl, E. Lorenz, M. Reindl Toll-like receptor 4 polymorphisms and atherogenesis in humans N Engl J Med 347 2002 185 192
28. G. Schett, S. Kiechl, K. Redlich Soluble RANKL and risk of nontraumatic fracture JAMA 291 2004 1108 1113
29. R.J. Jarrett Impaired glucose tolerance and diabetes--WHO criteria BMJ 282 1981 990
30. E. Bonora, G. Targher, M. Alberiche Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity studies in subjects with various degree of glucose tolerance and insulin sensitivity Diabetes Care 23 2000 57 63
31. E. Bonora, S. Kiechl, J. Willeit Metabolic syndrome epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck-Study. Int J Obes Relat Metab Disord 27 2003 1283 1289
32. R. Malmstrom, M.R. Taskinen, S.L. Karonen, H. Yki-Jarvinen Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM Diabetologia 39 1996 993 996
33. L. Berti, M. Kellerer, E. Capp, H.U. Haring Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes evidence for a P13-kinase mediated effect Diabetologia 40 1997 606 609
34. E. Ravussin, R.E. Pratley, M. Maffei Relatively low plasma leptin concentrations precede weight gain in Pima Indians Nat Med 3 1997 238 240
35. R. Saladin, P. De Vos, M. Guerre-Millo Transient increase in obese gene expression after food intake or insulin administration Nature 377 1995 527 529
36. J.F. Caro, J.W. Kolaczynski, M.R. Nyce Decreased cerebrospinal-fluid/ serum leptin ratio in obesity a possible mechanism for leptin resistance Lancet 348 1996 159 161
37. A. Ghazali, F. Grados, R. Oprisiu Bone mineral density directly correlates with elevated serum leptin in haemodialysis patients Nephrol Dial Transplant 18 2003 1882 1890
38. M.W. Hamrick, C. Pennington, D. Newton Leptin deficiency produces contrasting phenotypes in bones of the limb and spine Bone 34 2004 376 383