Synthesis of 3H and 14C labeled (S)-3-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6- (trifluoromethyl)-2H-indol-2-one, Maxipost™. An agent for post-stroke neuroprotection

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 46, Issue 2, 2003, Pages 139-149

  Dischino, Douglas D ^a   Gribkoff, Valentin K ^a   Hewawasam, Piyasena ^a   Luke, George M ^a   Rinehart, J Kent ^a   Spears, Tony L ^a   Starrett, John E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Carbon 14; Maxipost ; Neuroprotection; Stroke; Tritium

Indexed keywords

CARBON; CARBOXYLATION; ENANTIOMERS; PURIFICATION;

CARBON 14; CHIRAL HPLC; FOUR-STEP SYNTHESIS; MAXIPOST™; NEUROPROTECTION; RADIOCHEMICAL YIELD; SPECIFIC ACTIVITY; STROKE; TRIFLUOROMETHYL; TWO-STEP SYNTHESIS;

TRITIUM;

3 (5 CHLORO 2 METHOXYPHENYL) 1,3 DIHYDRO 3 FLUORO 6 (TRIFLUOROMETHYL) 2H INDOL 2 ONE; 3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; CARBON 14; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; NEUROPROTECTION; RADIOCHEMISTRY; STROKE;

TRITIUM;

EID: 0037328508     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.652     Document Type: Article

References (6)

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3. Gribkoff VK, Starrett Jr. JE, Dworetzky SI, et al. Nature Med 2001; 7: 471-477.
4. Hewawasam P, Meanwell NA, Gribkoff VK. US Patent # 5,565,483, 15 October 1996.
5. Hewawasam P, Gribkoff VK, Pendri Y, et al. Bioorg Med Chem Lett 2002; 12: 1023-1026.
6. Hewawasam P, Erway M, Moon SL, et al. J Med Chem 2002; 45: 1487-1499.