Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats

Biopharmaceutics and Drug Disposition

Volumn 23, Issue 6, 2002, Pages 233-237

  Krishna, Rajesh ^a   Shah, Vinod R ^a   Srinivas, Nuggehally ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

BMS 204352; Dose proportionality; Pharmacokinetics; Rats

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; POTASSIUM CHANNEL STIMULATING AGENT;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CAROTID ARTERY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INFUSION; DRUG SCREENING; FEMALE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEAN RESIDENCE TIME; NONHUMAN; PARALLEL DESIGN; RAT; SEX DIFFERENCE; STEADY STATE; STROKE; VALIDATION PROCESS;

ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDOLES; INJECTIONS, INTRA-ARTERIAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; TIME FACTORS;

EID: 0036740553     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.318     Document Type: Article

References (7)

1. Gribkoff VK, Starrett Jr JE, Dworetzky SI, et al. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nat Med 2001; 7: 471-477.
2. Cheney JA, Weisser JD, Bareyre FM, et al. The maxi-K channel opener BMS-204352 attenuates regional cerebral edema and neurologic motor impairment after experimental brain injury. J Cereb Blood Flow Metab 2001; 21: 396-403.
3. Starrett JE, Dworetzky SI, Gribkoff VK. Modulators of large conductance calcium-activated potassium (BK) channels as potential therapeutic targets. Curr Pharm Des 1996; 2: 413-428.
4. Starrett JE, Hewawasam P, Oritz AA, et al. Synthesis, pharmacokinetic analysis and MCAO stroke activity of the maxi-K opener BMS-204352. Proc Keystone Symposium Potassium Channels, Keystone CO, 2000; 57.
5. Gibaldi M, Perrier D. Pharmacokinetics (2nd edn). Marcel Dekker: New York, 1982.
6. Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm Res 1993; 10: 1093-1095.
7. Waxman DJ, Dannan GA, Guengerich FP. Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isozymes. Biochem 1985; 24: 4409-4417.