Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue

Journal of Thoracic and Cardiovascular Surgery

Volumn 129, Issue 1, 2005, Pages 25-32

  Rosenfeldt, Franklin ^a,b   Marasco, Silvana ^a   Lyon, William ^a   Wowk, Michelle ^a   Sheeran, Freya ^a   Bailey, Michael ^b   Esmore, Donald ^a   Davis, Bruce ^a   Pick, Adrian ^a   Rabinov, Mark ^a   Smith, Julian ^a   Nagley, Phillip ^b   Pepe, Salvatore ^a,c  

^a ALFRED HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; MALONALDEHYDE; PLACEBO; TROPONIN I; UBIDECARENONE; BIOLOGICAL MARKER; DRUG DERIVATIVE; UBIQUINONE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; ELECTIVE SURGERY; ENZYME THERAPY; FEMALE; HEART ATRIUM; HEART FUNCTION TEST; HEART HEMODYNAMICS; HEART MITOCHONDRION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART STRESS; HEART SURGERY; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL RESPIRATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN SECRETION; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; TISSUE LEVEL; ANALYSIS OF VARIANCE; COMPARATIVE STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; HEART CONTRACTION; HEMODYNAMICS; IN VITRO STUDY; LENGTH OF STAY; METHODOLOGY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY; PREOPERATIVE CARE; PROBABILITY; REFERENCE VALUE; RISK FACTOR; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AGED; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CORONARY ARTERY BYPASS; CORONARY DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEART FUNCTION TESTS; HEMODYNAMIC PROCESSES; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; PREOPERATIVE CARE; PROBABILITY; REFERENCE VALUES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SURGICAL PROCEDURES, ELECTIVE; TREATMENT OUTCOME; TROPONIN I; UBIQUINONE;

EID: 19944380418     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2004.03.034     Document Type: Article

References (29)

1. Lakatta E.G., Levy D. Arterial and cardiac aging major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease. Circulation. 107:2003;346-354
2. Alexander K.P., Peterson E.D. Coronary artery bypass grafting in the elderly. Am Heart J. 134:1997;856-864
3. Ivanov J., Weisel R.D., David T.E., Naylor C.D. Fifteen-year trends in risk severity and operative mortality in elderly patients undergoing coronary artery bypass graft surgery. Circulation. 97:1998;673-680
4. Frei B., Kim M.C., Ames B.N. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A. 87:1990;4879-4883
5. Turunen M., Swiezewska E., Chojnacki T., Sindelar P., Dallner G. Regulatory aspects of coenzyme Q metabolism. Free Radic Res. 36:2002;437-443
6. 10. Proc Natl Acad Sci U S A. 82:1985;901-904
7. 10 of patients in heart failure who are eligible or ineligible for a transplant. Biochem Biophys Res Commun. 182:1992;247-253
8. 10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress studies in rats and in human atrial tissue. Biofactors. 9:1999;291-299
9. Willis R.A., Folkers K., Tucker J.L., Ye C.Q., Xia L.J., Tamagawa H. Lovastatin decreases coenzyme Q levels in rats. Proc Natl Acad Sci U S A. 87:1990;8928-8930
10. Folkers K., Langsjoen P., Willis R., Richardson P., Xia L.J., Ye C.Q., et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci U S A. 87:1990;8931-8934
11. 10-lowering effect by HMG-CoA reductase inhibitors a double-blind, placebo-controlled study. J Clin Pharmacol. 33:1993;226-229
12. 10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med. 18:(suppl):1997;S137-144
13. 10 treatment improves the tolerance of the senescent myocardium to pacing stress in the rat. Cardiovasc Res. 40:1998;165-173
14. 10 on myocardial protection during cardiac valve replacement and scavenging free radical activity in vitro. J Cardiovasc Surg. 40:1999;355-361
15. 10 during heart surgery. Clin Investig. 71:(suppl 8):1993;155-161
16. 10 on myocardial protection during cardiac operations. Ann Thorac Surg. 61:1996;829-833
17. 10 the prophylactic effect on low cardiac out put following cardiac valve replacement. Ann Thorac Surg. 33:(2):1982;145-151
18. 10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg. 58:1994;1427-1432
19. 10 on myocardial preservation during hypothermic cardioplegic arrest. J Thorac Cardiovasc Surg. 107:1994;242-247
20. Pepe S., Tsuchiya N., Lakatta E.G., Hansford R.G. Modulation of cardiac membrane lipids and aging affect activation of pyruvate dehydrogenase and coupling of oxidative phosphorylation. Am J Physiol. 276:1999;H149-158
21. Mariani J., Ou R., Bailey M., Rowland M., Nagley P., Rosenfeldt F., et al. Tolerance to ischemia and hypoxia is reduced in aged human myocardium. J Thorac Cardiovasc Surg. 120:2000;660-667
22. Chrispin P.S., Scotton H., Roger J., Lloyd D., Ridley A. Short Form 36 in the intensive care unit assessment of acceptability, reliability and validity of the questionnaire. Anaesthesia. 52:1997;15-23
23. Misare B., Krukenkamp I., Levitsky S. Age-dependent sensitivity to unprotected cardiac ischemia the senescent myocardium. J Thorac Cardiovasc Surg. 103:1992;60-65
24. 10 of canine myocardial reperfusion injury after preservation. J Thorac Cardiovasc Surg. 103:1992;945-951
25. 10 supplement renders swine hearts resistant to ischemia-reperfusion injury. Am J Physiol. 278:2000;H1084-1090
26. Ferrara N., Abete P., Ambrosio G., Landino P., Caccese P., Cirillo P., et al. Protective role of chronic ubiquinone administration on acute cardiac oxidative stress. J Pharmacol Exp Ther. 274:1995;858-865
27. 2+ overload during postischemic reperfusion. Am J Physiol. 266:1994;H2174-2181
28. 10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem. 278:2003;28220-28228
29. Di Lisa F., Canton M., Menabo R., Dodoni G., Bernardi P. Mitochondria and reperfusion injury. The role of permeability transition. Basic Res Cardiol. 98:2003;235-241