Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations

Annals of Thoracic Surgery

Volumn 61, Issue 3, 1996, Pages 829-833

  Taggart, David P ^a,b   Jenkins, Michael ^a   Hooper, James ^a   Hadjinikolas, Leon ^a   Kemp, Michael ^a   Hue, Dominic ^a   Bennett, Graeme ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; UBIDECARENONE;

ADULT; AGED; ARTICLE; CARDIOPLEGIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ELECTROCARDIOGRAM; FEMALE; HEART INFARCTION; HEART PROTECTION; HEART SURGERY; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION;

EID: 0029938971     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/0003-4975(95)01120-X     Document Type: Article

References (14)

1. Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608.
2. Mori F, Mohri H. Effects of coenzyme Q10 added to a potassium cardioplegic solution for myocardial protection during ischemic cardiac arrest. Ann Thorac Surg 1985;39: 30-6.
3. Okamoto F, Allen BS, Buckberg GD, Leaf J, Bugyi H. Studies of controlled reperfusion after ischemia. X. Reperfusate composition: supplemental role of intravenous and intracoronary coenzyme Q10 in avoiding reperfusion damage. J Thorac Cardiovasc Surg 1986;92:573-82.
4. Matsushima T, Sueda T, Matsuura Y, Kawasaki T. Protection by coenzyme Q10 of canine myocardial reperfusion injury after preservation. J Thorac Cardiovasc Surg 1992;103:945-51.
5. Ali K, Morimoto M, Fukaya Y, Furukawa Y. Improvement of cardiac function impaired by repeated ischemic arrests in isolated rat hearts. Ann Thorac Surg 1993;55:902-7.
6. Tanaka J, Tominaga R, Yoshitoshi M, et al. Coenzyme Q10: the prophylactic effect on low cardiac output following cardiac valve replacement. Ann Thorac Surg 1982;33:145-51.
7. Chen YF, Young-Tso L, Chuan S. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. J Thorac Cardiovasc Surg 1994;107:242-7.
8. Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg 1994;58: 1427-32.
9. Judy WV, Stogsdill WW, Folkers K. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. J Clin Invest 1993;71(Suppl 8):155-61.
10. Sunamori M, Tanaka H, Maruyama T, Sultan I, Sakamoto T, Suzuki A. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovasc Drugs Ther 1991;5:297-300.
11. Seguin J, Saussine M, Ferriere M, et al. Comparison of myoglobin and creatine kinase MB levels in the evaluation of myocardial injury after cardiac operations. J Thorac Cardiovasc Surg 1988;95:294-7.
12. Taggart DP, Bhusari S, Hooper I, et al. Intermittent ischaemic arrest and cardioplegia in coronary artery surgery: coming full circle? Br Heart J 1994;72:136-9.
13. Taggart DP, Young V, Hooper J, et al. Lack of cardioprotective efficacy of allopurinol in coronary artery surgery. Br Heart J 1994;71:177-81.
14. Folkers K. Perspectives from research on vitamins and hormones. J Chem Educ 1984;61:747-56.