Dietary coenzyme Q10 supplement renders swine hearts resistant to ischemia-reperfusion injury

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 278, Issue 4 47-4, 2000, Pages

  Maulik, Nilanjana ^b   Yoshida, Tetsuya ^b   Engelman, Richard M ^b   Bagchi, Debasis ^b   Otani, Hajime ^b   Das, Dipak K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Oxidative stress; Oxygen free radicals; Ubiquinone; Ubiquitin

Indexed keywords

UBIDECARENONE; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; HEART MUSCLE ISCHEMIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; SWINE;

EID: 0034012734     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.278.4.h1084     Document Type: Article

References (36)

1. Bagchi, D., D. K. Das, R. M. Engelman, M. R. Prasad, and R. Subramanian. Polymorphonuclear leucocytes as potential source of free radicals in the ischaemic-reperfused myocardium. Eur. Heart J. 11: 800-813, 1990.
2. Cadenas, E., P. P. Hochstein, and L. Ernster. Pro-and antioxidant functions of quinones and quinone reductases in mammalian cells. Adv. Enzymol. Relat. Areas Mol. Biol. 65: 97-147, 1992.
3. Cordis, G. A., D. Bagchi, N. Maulik, and D. K. Das. High-performance liquid chromatographic method for the simultaneous detection of malonaldehyde, acetaldehyde, formaldehyde, acetone and propionaldehyde to monitor the oxidative stress in heart. J. Chromatogr. A 661: 181-191, 1994.
4. Cordis, G. A., G. Maulik, D. Bagchi, W. Riedel, and D. K. Das. Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8-hydroxydeoxyguanosine formation. J. Mol. Cell Cardiol. 30: 1939-1944, 1998.
5. Cordis, G. A., N. Maulik, and D. K. Das. Detection of oxidative stress in heart by estimating the dinitrophenylhydrazine derivative of malonaldehyde. J. Mol. Cell Cardiol. 27: 1645-1653, 1995.
6. Das, D. K., R. M. Engelman, X. Liu, S. Maity, J. A. Rousou, J. Flack, J. Laksmipati, R. M. Jones, M. R. Prasad, and D. W. Deaton. Oxygen derived free radicals and hemolysis during open heart surgery. Mol. Cell. Biochem. 111: 77-86, 1992.
7. Das, D. K., R. M. Engelman, J. A. Rousou, R. H. Breyer, and S. Lemeshow. Pathophysiology of superoxide radical as a potential mediator of reperfusion injury in pig heart. Basic Res. Cardiol. 81: 155-166, 1986.
8. Das, D. K., and N. Maulik. Antioxidant effectiveness in ischemia-reperfusion tissue injury. Methods Enzymol. 233: 601-610, 1994.
9. Das, D. K., and N. Maulik. Protection against free radical injury in the heart and cardiac performance. In: Exercise and Oxygen Toxicity, edited by C. K. Sen, L. Packer, and O. Hänninen. Amsterdam, The Netherlands: Elsevier Science, 1995, p. 359-388.
10. Das, D. K., and N. Maulik. Role of small HSP gene expression in myocardial ischemia and reperfusion. In: Heat Shock Proteins and the Cardiovascular Systems, edited by A. A. Knowlton. Norwell, MA: Kluwer Academic, 1997, p 159-181.
11. 10, alpha-tocopherol and cholesterol in biological samples by coupled-column liquid chromatography with coulometric and ultraviolet detection. J. Chromatogr. 425: 87-97, 1988.
12. Engelman, D. T., M. Watanabe, R. M. Engelman, J. A. Rousou, E. Kisin, V. E. Kagan, N. Maulik, and D. K. Das. Hypoxic preconditioning preserves antioxidant reserve in the working rat heart. Cardiovasc. Res. 29: 133-140, 1995.
13. Ernster, L. Ubiquinol as a biological antioxidant. In: Active Oxygens, Lipid Peroxides and Antioxidants, edited by K. Yagi. Tokyo: Japan Sci. Soc., 1993, p. 1-38.
14. Ernster, L., and G. Dalner. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta 1271: 195-204, 1995.
15. Ferrara, N., P. Abete, G. Ambrosio, P. Landino, P. Caccese, P. Cirillo, A. Oradei, G. P. Littarru, M. Chiariello, and F. Rengo. Protective role of chronic ubiquinone administration on acute cardiac oxidative stress. J. Pharmacol. Exp. Ther. 274: 858-865, 1995.
16. Frei, B., M. C. Kim, and B. N. Ames. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. USA 87: 4879-4883, 1990.
17. Hanaki, Y., S. Sugiyama, T. Ozawa, and M. Ohno. Ratio of low-density lipoprotein cholesterol to ubiquinone as a coronary risk factor. N. Engl. J. Med. 325: 814-815, 1991.
18. 2+ overload during postischemic reperfusion. Am. J. Physiol. Heart Circ. Physiol. 266: H2174-H2181, 1994.
19. Haramaki, N., D. B. Stewart, S. Aggarwal, H. Ikeda, A. Z. Reznick, and L. Packer. Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion. Free Radic. Biol. Med. 25: 329-339, 1998.
20. Hershko, A., and A. Ciechanover. The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61: 761-807, 1992.
21. Jentsch, S., W. Seufert, T. Sommer, and H. A. Reines. Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells. Trends Biochem. Sci. 15: 195-198, 1990.
22. 10 reductase generates semiquinone radicals and recycles vitamin E homologue in a superoxide-dependent reaction. FEBS Lett. 428: 43-46, 1998.
23. Konishi, T., Y. Nakamura, T. Konishi, and C. Kawai. Accentuated negative inotropism of verapamil after ischaemic intervention in isolated working rat heart. Cardiovasc. Res. 19: 38-43, 1984.
24. Kramer, J. H., V. Misik, and W. B. Weglicki. Lipid peroxidation-derived free radical production and postischemic myocardial reperfusion injury. Ann. NY Acad. Sci. 723: 180-196, 1994.
25. Liu, X., R. M. Engelman, I. I. Moraru, J. A. Rousou, J. E. Flack, D. W. Deaton, N. Maulik and D. K. Das. Heat shock: a new approach for myocardial preservation in cardiac surgery. Circulation 86: 358-363, 1992.
26. Maulik, N., H. Sharma, and D. K. Das. Induction of the haem oxygenase gene expression during the reperfusion of ischemic rat myocardium. J. Mol. Cell. Cardiol 28: 1261-1270, 1996.
27. Maulik, N., M. Watanabe, D. T. Engelman, R. M. Engelman, V. E. Kagan, E. Kisin, V. Tyurin G. A. Cordis, and D. K. Das. Myocardial adaptation to ischemia by oxidative stress induced by endotoxin. Am. J. Physiol. Cell Physiol. 269: C907-C916, 1995.
28. Mortensen, S. A. Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone). Clin. Investig. 71, Suppl 8: S116-S123, 1993.
29. 10, edited by Y. Yamamura, K. Folkers, and Y. Ito. New York: Elsevier/North Holland Biomedical, 1980, vol. 2, p. 3-14.
30. Parag, H.A., B. Raboy, and R. G. Kulka. Effect of heat shock on protein degradation in mammalian cells: involvement of the ubiquitin system. EMBO J. 6: 55-63, 1987.
31. Sharma, H. S., D. K. Das, and P. D. Verdouw. Enhanced expression and localization of heme oxygenase-1 during recovery phase of porcine stunned myocardium. Mol. Cell. Biochem. 196: 133-139, 1999.
32. Sharma, H. S., N. Maulik, B. C. G. Gho, D. K. Das, and P. D. Verdouw. Coordinated expression of heme oxygenase-1 and ubiquitin in the porcine heart subjected to ischemia and reperfusion. Mol. Cell. Biochem. 157: 111-116, 1996.
33. Singal, P. K., and L. A. Kirchenbaum. A relative deficit in antioxidant reserve may contribute in cardiac failure. Can. J. Cardiol. 6: 47-49, 1990.
34. Stocker, R., V. W. Bowry, and B. Frei. Ubiquinol-10 protects human low-density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc. Natl. Acad. Sci. USA 88: 1646-1650, 1991.
35. 10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovasc. Drugs Ther. 5: 297-300, 1991.
36. Szarkowska, L. The restoration of NADPH oxidase activity by coenzyme Q (ubiquinone). Arch. Biochem. Biophys. 113: 519-525, 1966.