Diffuse encephaloventriculitis and substantial leukoencephalopathy after intraventricular administration of recombinant adenovirus

Neurological Research

Volumn 27, Issue 4, 2005, Pages 378-386

  Tada, Tsuyoshi ^a   Nguyen, John Bang ^b   Hitoshi, Yasuyuki ^b   Watson, Nathan P ^b   Dunn, Jeffrey F ^b   Ohara, Shinji ^c   Nagano, Satoshi ^d   Kosai, Ken Ichiro ^d   Israel, Mark A ^b  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c Matsumoto Hospital   (Japan)

^d KURUME UNIVERSITY   (Japan)

Author keywords

Adenovirus; Encephaloventriculitis; Leukoencephalopathy; Mouse; Ventricles

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN VENTRICULITIS; CELL PROLIFERATION; EPENDYMA CELL; GENE EXPRESSION; GENE TRANSFER; HISTOPATHOLOGY; IMMUNE RESPONSE; INOCULATION; LEUKOENCEPHALOPATHY; LYMPHOCYTIC INFILTRATION; MOUSE; MYELINATED NERVE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; VIRUS PARTICLE; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; BRAIN; DEMENTIA, VASCULAR; DNA, SINGLE-STRANDED; ENCEPHALITIS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; LATERAL VENTRICLES; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; STAINING AND LABELING; TIME FACTORS;

EID: 19544393541     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164105X22075     Document Type: Article

References (44)

1. Wright JL, Merchant RE. Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-alpha in the rat. J Neurooncol 1994; 20: 17-25
2. Kern MA, Bamborschke S, Nekic M, et al. Concentrations of hepatocyte growth factor in cerebrospinal fluid under normal and different pathological conditions. Cytokine 2001; 14: 170-176
3. Pan W, Kastin AJ. Interactions of cytokines with the blood-brain barrier: Implications for feeding. Curr Pharm Des 2003; 9: 827-831
4. Baker D, Hankey DJ. Gene therapy in autoimmune, demyelinating disease of the central nervous system. Gene Ther 2003; 10: 844-853
5. Ooboshi H, Welsh MJ, Rios CD, et al. Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue. Circ Res 1995; 77: 7-13
6. Viola JJ, Ram Z, Walbridge S, et al, Adenovirally mediated gene transfer into experimental solid brain tumors and leptomeningeal cancer cells. J Neurosurg 1995; 82: 70-76
7. Shimamura M, Sato N, Oshima K, et al. Novel therapeutic strategy to treat brain ischemia: Overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation 2004; 109: 424-431
8. Le Gal La Salle G, Robert JJ, Berrard S, et al. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 1993; 259: 988-990
9. Breakefield XO. Gene delivery into the brain using virus vectors. Nature Genet 1993; 3: 187-189
10. Bajocchi G, Feldman SH, Crystal RG, et al. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nature Genet 1993; 3: 229-234
11. Yoon SO, Lois C, Alvirez M, et al. Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain. Proc Natl Acad Sci USA 1996; 93: 11974-11979
12. Kitagawa H, Setoguchi Y, Fukuchi Y, et al. DNA fragmentation and HSP72 gene expression by adenovirus-mediated gene transfer in postischemic gerbil hippocampus and ventricle. Metab Brain Dis 1998; 13: 211-223
13. Yang GY, Liu XH, Kadoya C, et al. Attenuation of ischemic inflammatory response in mouse brain using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist. J Cereb Blood Flow Metab 1998; 18: 840-847
14. Abe K, Kitagawa H, Setoguchi Y. Temporal profile of adenovirus-mediated E. coli lacZ gene expression in normal and post-ischemic gerbil hippocampus and ventricle. Neurol Res 1998; 20: 689-696
15. Driesse MJ, Kros JM, Avezaat CJ, et al. Distribution of recombinant adenovirus in the cerebrospinal fluid of nonhuman primates. Hum Gene Ther 1999; 10: 2347-2354
16. Davidson BL, Stein CS, Heth JA, et al. Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system. Proc Natl Acad Sci USA 2000; 97: 3428-3432
17. Yagi T, Maeda M, Tanaka A, et al. Detection of the exogenous hGDNF in gerbils under the treatment with AxCAhGDNF adenoviral vector. Brain Res Brain Res Protoc 2001; 8: 88-98
18. Lin H, Lin TN, Cheung WM, et al. Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Circulation 2002; 105: 1962-1969
19. Shirakura M, Fukumura M, Inoue M, et al. Sendai virus vector-mediated gene transfer of glial cell line-derived neurotrophic factor prevents delayed neuronal death after transient global ischemia in gerbils. Exp Anim 2003; 52: 119-127
20. Matsuoka N, Nozaki K, Takagi Y, et al. Adenovirus-mediated gene transfer of fibroblast growth factor-2 increases BrdU-positive cells after forebrain ischemia in gerbils. Strafe 2003; 34: 1519-1525
21. Zeimet AG, Marth C. Why did p53 gene therapy fail in ovarian cancer? Lancet Oncol 2003; 4: 415-422
22. Rainov NG, Ren H. Gene therapy for human malignant brain tumors. Cancer J 2003; 9: 180-188
23. Dai Y, Schwarz EM, Gu D, et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA 1995; 92: 1401-1405
24. Ohmoto Y, Wood MJ, Charlton HM, et al. Variation in the immune response to adenoviral vectors in the brain: Influence of mouse strain, environmental conditions and priming. Gene Ther 1999; 6: 471-481
25. Akli S, Caillaud C, Vigne E, et al. Transfer of a foreign gene into the brain using adenovirus vectors. Nature Genet 1993; 3: 224-228
26. Davidson BL, Allen ED, Kozarsky KF, et al. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nature Genet 1993; 3: 219-223
27. Dewey RA, Morrissey G, Cowsill CM, et al. Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials. Nat Med 1999; 5: 1256-1263
28. Kielian T, Mickey WF. Inflammatory thoughts about glioma gene therapy. Nat Med 1999; 5: 1237-1238
29. Principles of Laboratory Animal Care formulated by the National Society for Medical Research
30. Guide for the Care and Use of Laboratory Animals prepared by the Institute of Laboratory Animal Resource. NIH Publication No. 86-23, revised 1985
31. Chen SH, Chen XH, Wang Y, et al. Combination gene therapy for liver metastasis of colon carcinoma in vivo. Proc Natl Acad Sci USA 1995; 92: 2577-2581
32. Terazaki Y, Yano S, Yuge K, et al. An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice. Hepatology 2003; 37: 155-163
33. Cruz JI, Loste JM, Burzaco OH. Observations on the use of medetomidine/ketamine and its reversal with atipamezole for chemical restraint in the mouse. Lab Anim 1998; 32: 18-22
34. Byrnes AP, Rusby JE, Wood MJ, et al. Adenovirus gene transfer causes inflammation in the brain. Neuroscience 1995; 66: 1015-1024
35. Perry VH, Andersson PB, Gordon S. Macrophages and inflammation in the central nervous system. Trends Neurosci 1993; 16: 268-273
36. Lowenstein PR, Castro MG. Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: Peculiarities, mechanisms, and consequences. Gene Ther 2003; 10: 946-954
37. Ghodsi A, Stein C, Derksen T, et al. Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain. Hum Gene Ther 1998; 9: 2331-2340
38. Driesse MJ, Esandi MC, Kros JM, et al. Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity. Gene Ther 2000; 7: 1401-1409
39. Lieberman AP, Pitha PM, Shin HS, et al. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci USA 1989; 86: 6348-6352
40. Selmaj K, Raine CS, Farooq M, et al. Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin. J Immunol 1991; 147: 1522-1529
41. Shamash S, Reichert F, Rotshenker S. The cytokine network of Wallerian degeneration: Tumor necrosis factor-alpha, interleukin-1 alpha, and interleukin-1beta. J Neurosci 2002; 22: 3052-3060
42. Selmaj KW, Farooq M, Norton WT, et al. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J Immunol 1990; 144: 129-135
43. McMenamin PG. Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations. J Comp Neurol 1999; 405: 553-562
44. Serdar M. Periventricular lucency on computed tomography associated with hydrocephalus: What is the cause? Surg Neurol 1995; 44: 285-286