Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides

Organic Letters

Volumn 7, Issue 10, 2005, Pages 2035-2038

  Hu, Tianshun ^a   Li, Chaozhong ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; COPPER; DIOXANE; LACTAM DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; STRUCTURE ANALYSIS; SYNTHESIS; X RAY DIFFRACTION;

AMIDES; CATALYSIS; COPPER; CYCLIZATION; LACTAMS; MOLECULAR STRUCTURE;

EID: 19544380068     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0505555     Document Type: Article

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46. When a catalytic amount of CuI (10 mol %) was employed, only a trace amount of 13 could be detected along with unidentified decomposition products, probably because 13 was not very stable under the reaction conditions for a prolonged time. An alternative explanation might be that Cu(I) acted as a chelating template for the formation of 13.