Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1729, Issue 1, 2005, Pages 24-31

  Hauke, Sven ^a   Leopold, Silke ^b   Schlueter, Claudia ^b   Flohr, Aljoscha M ^b   Escobar, Hugo Murua ^c   Rogalla, Piere ^a   Bullerdiek, Jörn ^b  

^a ZytoVision GmbH   (Germany)

^b UNIVERSITY OF BREMEN   (Germany)

^c UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Alternative splicing; Benign tumor; Chromosomal rearrangement; High mobility group protein gene HMGA2

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CONSENSUS; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; KARYOTYPE; LIPOMA; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

ALTERNATIVE SPLICING; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HMGB3 PROTEIN; HUMANS; INTRONS; NEOPLASMS; QUANTITATIVE TRAIT LOCI; RNA SPLICE SITES;

EID: 19544370370     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2005.03.006     Document Type: Article

References (43)

1. R. Grosschedl, K. Giese, and J. Pagel HMG domain proteins: architectural elements in the assembly of nucleoprotein structures Trends Genet. 10 1994 94 100
2. M. Bustin, and R. Reeves High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function Prog. Nucleic Acid Res. Mol. Biol. 54 1996 35 100
3. K.Y. Chau, U.A. Patel, K.L. Lee, H.Y. Lam, and C. Crane-Robinson The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element Nucleic Acids Res. 23 1995 4262 4266
4. S. Wanschura, B. Kazmierczak, Y. Pohnke, K. Meyer-Bolte, S. Bartnitzke, W.J. Van de Ven, and J. Bullerdiek Transcriptional activation of HMGI-C in three pulmonary hamartomas each with a der(14)t(12;14) as the sole cytogenetic abnormality Cancer Lett. 102 1996 17 21
5. G. Tallini, P. Dal Cin, K.J. Rhoden, G. Chiapetta, G. Manfioletti, V. Giancotti, A. Fusco, B.H. Van den, and R. Sciot Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations Am. J. Pathol. 151 1997 37 43
6. M. Klotzbücher, A. Wasserfall, and U. Fuhrmann Misexpression of wild-type and truncated isoforms of the high-mobility group I proteins HMGI-C and HMGI(Y) in uterine leiomyomas Am. J. Pathol. 155 1999 1535 1542
7. K. Kurose, N. Mine, D. Doi, Y. Ota, K. Yoneyama, H. Konishi, T. Araki, and M. Emi Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma Genes Chromosomes Cancer 27 2000 303 307
8. E.F. Schoenmakers, S. Wanschura, R. Mols, J. Bullerdiek, B.H. Van den, and W.J. Van de Ven Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours Nat. Genet. 10 1995 436 444
9. M.M. Petit, E.F. Schoenmakers, C. Huysmans, J.M. Geurts, N. Mandahl, and W.J. Van de Ven LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes Genomics 57 1999 438 441
10. B. Kazmierczak, J. Rosigkeit, S. Wanschura, K. Meyer-Bolte, W.J. Van de Ven, K. Kayser, B. Krieghoff, H. Kastendiek, S. Bartnitzke, and J. Bullerdiek HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors Oncogene 12 1996 515 521
11. M.M. Petit, R. Mols, E.F. Schoenmakers, N. Mandahl, and W.J. Van de Ven LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family Genomics 36 1996 118 129
12. B. Kazmierczak, Y. Hennig, S. Wanschura, P. Rogalla, S. Bartnitzke, D. Van, and V.J. Bullerdiek Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene Cancer Res. 55 1995 6038 6039
13. E.F. Schoenmakers, C. Huysmans, and W.J. Van de Ven Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas Cancer Res. 59 1999 19 23
14. S. Hauke, V. Rippe, and J. Bullerdiek Chromosomal rearrangements leading to abnormal splicing within intron 4 of HMGIC? Genes Chromosomes Cancer 30 2001 302 304
15. K. Kurose, N. Mine, A. Iida, H. Nagai, H. Harada, T. Araki, and M. Emi Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas Genes Chromosomes Cancer 30 2001 212 217
16. N. Mine, K. Kurose, H. Nagai, D. Doi, Y. Ota, K. Yoneyama, H. Konishi, T. Araki, and M. Emi Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas J. Hum. Genet. 46 2001 408 412
17. B.J. Quade, S. Weremowicz, D.M. Neskey, R. Vanni, C. Ladd, P. Dal Cin, and C.C. Morton Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15 Cancer Res. 63 2003 1351 1358
18. H.R. Ashar, M.S. Fejzo, A. Tkachenko, X. Zhou, J.A. Fletcher, S. Weremowicz, C.C. Morton, and K. Chada Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains Cell 82 1995 57 65
19. T. Takahashi, N. Nagai, H. Oda, K. Ohama, N. Kamada, and K. Miyagawa Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma Genes Chromosomes Cancer 30 2001 196 201
20. P. Rogalla, K. Drechsler, W. Schroder-Babo, K. Eberhardt, and J. Bullerdiek HMGIC expression patterns in non-small lung cancer and surrounding tissue Anticancer Res. 18 1998 3327 3330
21. M. Fedele, M.T. Berlingieri, S. Scala, L. Chiariotti, G. Viglietto, V. Rippel, J. Bullerdiek, M. Santoro, and A. Fusco Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts Oncogene 17 1998 413 418
22. S. Battista, V. Fidanza, M. Fedele, A.J. Klein-Szanto, E. Outwater, H. Brunner, M. Santoro, C.M. Croce, and A. Fusco The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis Cancer Res. 59 1999 4793 4797
23. P. Arlotta, A.K. Tai, G. Manfioletti, C. Clifford, G. Jay, and S.J. Ono Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas J. Biol. Chem. 275 2000 14394 14400
24. M. Fedele, S. Battista, G. Manfioletti, C.M. Croce, V. Giancotti, and A. Fusco Role of the high mobility group A proteins in human lipomas Carcinogenesis 22 2001 1583 1591
25. B. Noro, B. Licheri, R. Sgarra, A. Rustighi, M.A. Tessari, K.Y. Chau, S.J. Ono, V. Giancotti, and G. Manfioletti Molecular dissection of the architectural transcription factor HMGA2 Biochemistry 42 2003 4569 4577
26. S. Hauke, A.M. Flohr, P. Rogalla, and J. Bullerdiek Sequencing of intron 3 of HMGA2 uncovers the existence of a novel exon Genes Chromosomes Cancer 34 2002 17 23
27. L.V. Kottickal, B. Sarada, H. Ashar, K. Chada, and L. Nagarajan Preferential expression of HMGI-C isoforms lacking the acidic carboxy terminal in human leukemia Biochem. Biophys. Res. Commun. 242 1998 452 456
28. P. Rogalla, C. Rohen, Y. Hennig, U. Deichert, U. Bonk, and J. Bullerdiek Telomere repeat fragment sizes do not limit the growth potential of uterine leiomyomas Biochem. Biophys. Res. Commun. 211 1995 175 182
29. H. Inoue, H. Nojima, and H. Okayama High efficiency transformation of Escherichia coli with plasmids Gene 96 1990 23 28
30. A.P. Feinberg, and B. Vogelstein A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity Anal. Biochem. 132 1983 6 13
31. S.F. Altschul, T.L. Madden, A.A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D.J. Lipman Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucleic Acids Res. 25 1997 3389 3402
32. M.B. Shapiro, and P. Senapathy RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression Nucleic Acids Res. 15 1987 7155 7174
33. B. Ruskin, A.R. Krainer, T. Maniatis, and M.R. Green Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro Cell 38 1984 317 331
34. N.L. Harris, and P. Senapathy Distribution and consensus of branch point signals in eukaryotic genes: a computerized statistical analysis Nucleic Acids Res. 18 1990 3015 3019
35. P. Senapathy, M.B. Shapiro, and N.L. Harris Splice junctions, branch point sites, and exons: sequence statistics, identification, and applications to genome project Methods Enzymol. 183 1990 252 278
36. C.C. MacDonald, and J.L. Redondo Reexamining the polyadenylation signal: were we wrong about AAUAAA? Mol. Cell. Endocrinol. 190 2002 1 8
37. I. Lemke, P. Rogalla, and J. Bullerdiek Large deletion of part of the HMGIC locus accompanying a t(3;12)(q27 approximately q28;q14 approximately q15) in a lipoma Cancer Genet. Cytogenet. 129 2001 161 164
38. T.A. Ayoubi, E. Jansen, S.M. Meulemans, and W.J. Van de Ven Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development Oncogene 18 1999 5076 5087
39. P. Rogalla, K. Drechsler, G. Frey, Y. Hennig, B. Helmke, U. Bonk, and J. Bullerdiek HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors Am. J. Pathol. 149 1996 775 779
40. G.J. Gattas, B.J. Quade, R.A. Nowak, and C.C. Morton HMGIC expression in human adult and fetal tissues and in uterine leiomyomata Genes Chromosomes Cancer 25 1999 316 322
41. M.D. Odero, F.H. Grand, S. Iqbal, F. Ross, J.P. Roman, J.L. Vizmanos, J. Andrieux, J.L. Lai, M.J. Calasanz, and N.C. Cross Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies Leukemia 19 2005 245 252
42. C. Blank, P. Rogalla, K.H. Tran, and J. Bullerdiek A novel high mobility group protein gene is a candidate for Xp22 abnormalities in uterine leiomyomas and other benign tumors Cancer Genet. Cytogenet. 121 2000 172 180
43. S.M. Mount A catalogue of splice junction sequences Nucleic Acids Res. 10 1982 459 472