Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: A novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency

Pediatric Research

Volumn 57, Issue 6, 2005, Pages 771-776

  Gerstner, Bettina ^a   Gratopp, Alexander ^a   Marcinkowski, Monika ^a   Sifringer, Marco ^a   Obladen, Michael ^a   Bührer, Christoph ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 3 HYDROXYGLUTARIC ACID; ANTIBODY; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE INHIBITOR; GLUTACONIC ACID; GLUTARIC ACID; GLUTARIC ACID DERIVATIVE; GLUTARYL COENZYME A DEHYDROGENASE; LIPOCORTIN 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN DEGENERATION; CELL LINE; CELL MATURATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEFICIENCY; FLOW CYTOMETRY; GENE EXPRESSION; GLUTARYL COENZYME A DEHYDROGENASE DEFICIENCY; METABOLITE; MICROGLIA; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGODENDROGLIA; PATHOGENESIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WHITE MATTER;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BASE SEQUENCE; BRAIN DISEASES, METABOLIC, INBORN; CASPASES; CELL DIFFERENTIATION; CELL LINE; GLUTARATES; GLUTARYL-COA DEHYDROGENASE; HUMANS; NERVE DEGENERATION; OLIGODENDROGLIA; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; RATS; RECEPTORS, GLUTAMATE; RNA, MESSENGER;

EID: 19444380168     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000157727.21503.8D     Document Type: Article

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