Liquid chromatography-mass spectrometry assay for quantitation of ifosfamide and its N-deschloroethylated metabolites in rat microsomal medium

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 820, Issue 2, 2005, Pages 251-259

  Storme, Thomas ^a,b   Mercier, Lionel ^a   Deroussent, Alain ^a   Re, Micheline ^a   Martens, Thierry ^b   Royer, Jacques ^b   Bourget, Philippe ^a   Vassal, Gilles ^a   Paci, Angelo ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Cyclophosphamide; HPLC ESI MS; Ifosfamide; Microsomal metabolism; Neurotoxicity

Indexed keywords

AMINES; CELLS; DRUG PRODUCTS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; TUMORS;

ANTITUMOR DRUG; ELECTROSPRAY IONIZATION; LOW LIMITS OF QUANTITATION (LLOQ); RAT LIVER MICROSOMES;

ASSAYS;

ACETIC ACID ETHYL ESTER; AMMONIUM FORMATE; CYCLOPHOSPHAMIDE; DRUG METABOLITE; IFOSFAMIDE; METHANOL; N 2 DESCHLOROETHYLIFOSFAMIDE; N 3 DESCHLOROETHYLIFOSFAMIDE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); ELECTROSPRAY MASS SPECTROMETRY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; MICROSOME; MONITORING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; IFOSFAMIDE; MICROSOMES, LIVER; RATS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 19444373297     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.03.023     Document Type: Article

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