Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection

Therapeutic Drug Monitoring

Volumn 22, Issue 5, 2000, Pages 613-620

  Kerbusch, Thomas ^a   Jeuken, Marie José ^a   Derraz, Jamila ^a   Van Putten, John W G ^b   Huitema, Alwin D R ^a   Beijnen, Jos H ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

2 Dechloroethylifosfamide; 3 Dechloroethylifosfamide; Gas chromatography mass spectrometry; Ifosfamide; Neurotoxicity

Indexed keywords

2 DECHLOROETHYLIFOSFAMIDE; 3 DECHLOROETHYLIFOSFAMIDE; CYCLOPHOSPHAMIDE; IFOSFAMIDE; NITROGEN; PHOSPHORUS; TROFOSFAMIDE; UNCLASSIFIED DRUG;

ALKALINIZATION; ARTICLE; DRUG CONFORMATION; DRUG DETERMINATION; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NEUROTOXICITY; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE DIAGNOSIS;

ANTINEOPLASTIC AGENTS, ALKYLATING; CHROMATOGRAPHY, GAS; CYCLOPHOSPHAMIDE; DRUG MONITORING; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; IFOSFAMIDE; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY;

EID: 0033807318     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200010000-00018     Document Type: Article

References (12)

1. Ifosfamide
2. Ifosfamide metabolism and pharmacokinetics
3. Studies on the metabolism of isophosphamide (NSC-109724 in man
4. The enigma of ifosfamide encephalopathy
5. Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma
6. Determination of the urinary excretion of ifosfamide and its phosphorated metabolites by phosphorus-31 nuclear magnetic resonance spectroscopy
7. Determination of urinary 2- and 3-dechloroethylated metabolites of ifosfamide by high-performance liquid chromatography
8. The determination of the enantiomers of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in plasma and urine using enantioselective gas chromatography with mass spectrometric detection
9. Chromatographic analysis of the enantiomers of ifosfamide and some of its metabolites in plasma and urine
10. Determination of iphosphamide and seven metabolites in blood plasma, as stable trifluoroacetyl derivatives by electron capture chemical ionozation GC-MS
11. Capillary gas chromatographic determination of ifosfamide in microvolumes of urine and plasma
12. Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine