Evaluation of factors to decrease plasma concentration of an HIV protease inhibitor, saquinavir in ethanol-treated rats

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 2, 2004, Pages 203-209

  Shibata, Nobuhito ^a   Kageyama, Michiharu ^a   Kimura, Keisuke ^a   Tadano, Jun ^a   Hukushima, Hiroto ^a   Namiki, Hitomi ^a   Yoshikawa, Yukako ^a   Takada, Kanji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

CYP3A; Ethanol consumption; P glycoprotein; Pharmacokinetics; Protease inhibitor; Saquinavir

Indexed keywords

ALCOHOL; CYCLOSPORIN A; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; KETOCONAZOLE; PROTEINASE INHIBITOR; SAQUINAVIR;

ALCOHOL CONSUMPTION; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONJUGATION; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; INTESTINE BLOOD FLOW; JEJUNUM MUCOSA; LIVER MICROSOME METABOLISM; MALE; METABOLIC CLEARANCE RATE; NONHUMAN; PORTAL VEIN; PROTEIN EXPRESSION; RAT; ANIMAL; BILE; BIOAVAILABILITY; BLOOD; CHEMICAL PHENOMENA; COMPARATIVE STUDY; DRINKING BEHAVIOR; DRUG INTERACTION; INTESTINE; INTESTINE ABSORPTION; LIVER; METABOLISM; MICROSOME; ORAL DRUG ADMINISTRATION; TIME; ULTRASTRUCTURE; WISTAR RAT;

ADMINISTRATION, ORAL; ALCOHOL DRINKING; ANIMALS; BILE; BIOLOGICAL AVAILABILITY; DEPRESSION, CHEMICAL; DRUG INTERACTIONS; ETHANOL; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HIV PROTEASE INHIBITORS; INTESTINAL ABSORPTION; INTESTINES; LIVER; MALE; MICROSOMES; P-GLYCOPROTEIN; RATS; RATS, WISTAR; SAQUINAVIR; TIME FACTORS;

EID: 16544373370     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.203     Document Type: Article

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