The endogenous CXXC motif governs the cadmium sensitivity of the renal Na+/glucose co-transporter

Journal of the American Society of Nephrology

Volumn 16, Issue 5, 2005, Pages 1257-1265

  Xia, Xiaobing ^a,b   Wang, Gang ^a   Peng, Yanchun ^b   Tu, Ming Gene ^c,d,e   Jen, Jimmy ^b   Fang, Hongqing ^f  

^a BEIJING 302 HOSPITAL   (China)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^f BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; CYSTEINE; GLUCOSE; INOSITOL; SODIUM GLUCOSE COTRANSPORTER; SODIUM GLUCOSE COTRANSPORTER 1; CYCLOHEXANE DERIVATIVE; GLUCOSE TRANSPORTER; IONOPHORE; LIGAND; MEMBRANE PROTEIN; METHYLGLUCOSIDE; N,N,N',N' TETRACYCLOHEXYL 3 OXAPENTANEDIAMIDE; N,N,N',N'-TETRACYCLOHEXYL-3-OXAPENTANEDIAMIDE; SLC5A1 PROTEIN, RAT;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CADMIUM POISONING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG EFFECT; KIDNEY TUBULE EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; ANIMAL; BINDING SITE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; KIDNEY; LIPID BILAYER; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; RAT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CADMIUM; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLOHEXANES; CYSTEINE; IONOPHORES; KIDNEY; LIGANDS; LIPID BILAYERS; MEMBRANE GLYCOPROTEINS; METHYLGLUCOSIDES; MOLECULAR SEQUENCE DATA; MONOSACCHARIDE TRANSPORT PROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; SODIUM-GLUCOSE TRANSPORTER 1;

EID: 19444364345     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2004070594     Document Type: Article

References (31)

1. Satarug S, Haswell-Elkins MR, Moore MR: Safe levels of cadmium intake to prevent renal toxicity in human subjects. Br J Nutr 84: 791-802, 2000
2. Piscator M: The nephropathy of chronic cadmium poisoning. In: Handbook of Experimental Pharmacology, edited by Foulkes EC, Springer, New York, 1986, pp 80-194
3. Kim YK, Choi JK, Kim JS, Park YS: Changes in renal function in cadmium-intoxicated rats. Pharmacol Toxicol 63: 342-350, 1988
4. Herak-Kramberger CM, Spindler B, Biber J, Murer H, Sabolic I: Renal type II Na/Pi cotransporter is strongly impaired whereas the Na/sulphate cotransporter and aquaporin-1 are unchanged in cadmium treated rats. Pflugers Arch 432: 336-344, 1996
5. Kim KR, Lee HY, Kim CK, Park YS: Alteration of renal amino acid transport system in cadmium-intoxicated rats. Toxicol Appl Pharmacol 106: 102-111, 1990
6. Leffler PE, Jin T, Nordberg GF: Nephrotoxic impact of multiple short-interval cadmium-metallothionein injections in the rat. Toxicology 112: 151-156, 1996
7. Blumenthal SS, Ren L, Lewand DL, Krezoksi SK, Petering DH: Cd decrease SGLT1 message RNA in mouse kidney cells. Toxicol Appl Pharmacol 149: 49-54, 1998
8. Herak-Kramberger CM, Brown D, Sabolic I: Cadmium inhibits vacuolar H+-ATPase and endocytosis in rat kidney cortex. Kidney Int 53: 1713-1726, 1998
9. Thevenod F, Friendmann JM: Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K+-ATPase through proteasomal and endo-/lysosomal proteolytic pathways. FASEB J 13: 1751-1761, 1999
10. Bevan C, Kinne-Saffran E, Foulkes EC, Kinne RK: Cadmium inhibition of L-alanine transporter into renal brush border membrane vesicles isolated from winter flounder. Toxicol Appl Pharmacol 101: 461-469, 1989
11. Kinne RK, Schütz H, Kinne-Saffran E: The effect of cadmium chloride in vitro on sodium-glutamate cotransport in brush border membrane vesicles isolated from rabbit kidney. Toxicol Appl Pharmacol 135: 216-221, 1995
12. Wright EM, Hager KM, Turk E: Sodium cotransport proteins. Curr Opin Cell Biol 4: 696-702, 1992
13. Wright EM: Renal Na+-glucose cotransporters. Am J Physiol Renal Physiol 280: F10-F18, 2001
14. Steel A, Hediger MA: The molecular physiology of sodium- and proton-coupled solute transporters. News Physiol Sci 13: 123-131, 1998
15. Turk E, Kerner CJ, Lostao MP, Wright EM: Membrane topology of the human Na+/glucose cotransporter SGLT1. J Biol Chem 271: 1925-1934, 1996
16. Panayotova-Heiermann M, Eskandari S, Truk E, Zampigji GA, Wright EM: Five transmembrane helices form the sugar pathway through the Na+/glucose cotransporter. J Biol Chem 272: 20324-20327, 1997
17. Lo B, Silverman M: Cysteine scanning mutagenesis of the segment between putative transmembrane helices IV and V of the high affinity Na+/glucose cotransporter SGLT1. Evidence that this region participates in the Na+ and voltage dependence of the transporter. J Biol Chem 273: 29341-29351, 1998
18. Xia X, Lin JT, Kinne RK: Binding of phlorizin to the isolated C-terminal extracellular loop of the Na+/glucose cotransporter assessed by intrinsic trypan fluorescence. Biochemistry 42: 6115-6120, 2003
19. Martin MG, Turk E, Lostao MP, Kerner C, Wright EM: Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption. Nat Genet 12: 216-220, 1996
20. Wang E, Erdahl WL, Hamidinia SA, Chapman CJ, Taylor RW, Pfeiffer DR: Transport properties of the calcium ionophore ETH-129. Biophys J 81: 3275-3284, 2001
21. Schlemmer SR, Sirotnak FM: Energy-dependent efflux of methotrexate in L1210 leukemia cells. Evidence for the role of an ATPase obtained with inside-out plasma membrane vesicles. J Biol Chem 267: 14746-14752, 1992
22. Warren L: The thiobarbituric acid assay of sialic acids. J Biol Chem 234: 1971-1975, 1959
23. Saborido A, Moro G, Megías A: Transverse tubule Mg(2+)-ATPase of skeletal muscle. J Biol Chem 266: 23490-23498, 1991
24. Lin JT, Stroh A, Kinne R: Renal sodium-D-glucose cotransport system. Involvement of tyrosine residues in sodium-transporter interaction. Biochim Biophys Acta 692: 210-217, 1982
25. +/glucose transporter (hSGLT1) in bacterial membrane vesicles. Biochemistry 42: 9147-9152, 2003
26. Scalera V, Natuzzi D, Prezioso G: Myo-inositol transport in rat intestinal brush border membrane vesicles, and its inhibition by D-glucose. Biochim Biophys Acta 1062: 187-192, 1991
27. Ahn DW, Kim YM, Kim KR, Park YS: Cd2+ binding and sodium-dependent solute transport in renal brush-border membrane vesicles. Toxicol Appl Pharmacol 154: 212-218, 1999
28. Conway ME, Poole LB, Hutson SM: Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase. Biochemistry 43: 7356-7364, 2004
29. Jeon K, Jeong J, Jue D: Thiol-reactive metal compounds inhibit NF-kappaB activation by blocking IkappaB kinase. J Immunol 164: 5981-5989, 2000
30. Griffin BA, Adams SR, Tsien RY: Specific covalent labeling of recombinant protein molecules inside live cells. Science 281: 269-272, 1998
31. Rudnick G: Mechanism of biogenic amine neurotransmitter transporters. In: Neurotransmitter Transporters: Structure, Function, and Regulation, edited by Reith MEA, Humana, Totowa, NJ, 1997, pp 73-100