Downregulatory Effect of AGI-1120 (α-Glucosidase Inhibitor) and Chaga Mushroom (Inonotus obliquus) on Cellular NF-κB Activation and Their Antioxidant Activity

Korean Journal of Pharmacognosy

Volumn 35, Issue 1, 2004, Pages 92-97

  Song, Hee Sun ^a   Lee, Young Jong ^a   Kim, Seung Kyoon ^a   Moon, Won Kuk ^b   Kim, Dong Woo ^b   Kim, Yeong Shik ^c   Moon, Ki Young ^a  

^a Gwangju Health College University   (South Korea)

^b En Biotechnology Co Ltd   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

AGI 1120 ( glucosidase inhibitor); Antioxidant; Chaga Mushroom (Inonotus obliquus); NF B activity; Radical scavenging activity

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; AGI 1120; ALPHA GLUCOSIDASE INHIBITOR; ASCORBIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INONOTUS OBLIQUUS EXTRACT; NATURAL PRODUCT; NITRIC OXIDE; SCAVENGER; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG SCREENING; HUMAN; HUMAN CELL; LIPID PEROXIDATION; NONHUMAN; PINE;

EID: 1942504223     PISSN: 02533073     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Fang, Y. Z., Yang, S., and Wu, G. (2002) Free radicals, antioxidants and nutrition. Nutrition 18: 872-879.
2. Gopalakrishna, R. and Gundimeda, U. (2002) Antioxidant regulation of protein kinase C in cancer prevention. J. Nutr. 132: 3819S-3823S.
3. Mayne, S. T. (2003) Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidermiologic research. J. Nutr. 133: 933S-940S.
4. Dragland, S., Senoo, H., Wake, K., Holte, K., and Blomhoff, R. (2003) Sveral culinary and medicinal herbs are important sources of dietary antioxidants. J. Nutr. 133: 1286-1290.
5. Suzuki, Y. J., Mizuno, M., and Packer, L. (1994) Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step. J. Immuno. 153: 5008-5015.
6. Li, N. and Karin, M. (1999) Is NF-κB the sensor of oxidative stress? FASEB J. 13: 1137-1143.
7. Meister, A. and Anderson, M. E. (1983) Glutathione. Annu. Rev. Biochem. 5: 711-760.
8. Aruoma, O. L., Halliwell, B., Hoey, B. M., and Butler, J. (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Rad. Biol. Med. 6: 593-597.
9. Traenckner, E. B., Wilk, S., and Baeuerle, P. A. (1994) A proteasome inhibitor prevents activation of NF-κB and stabilize a newly phosphorylated form of IB-alpha that is still bound to NF-B. EMBO. J. 13: 5433-5444.
10. Baeuerle, P. A. and Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12: 141-149.
11. Baeuerle, P. A. and Baichwal, V. R. (1997) NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv. Immunol. 65: 111-137.
12. Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., and Karin, M. (1995) Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of I-κB synthesis. Science 270: 286-290.
13. Baldwin, A. S. (1996) The NF-κB and I-κB proteins-New discoveries and insights. Annu. Rev. Immunol. 14: 649-683.
14. Baeuerle, P. A. (1991) The inducible transcription factor NF-κB-regulation by distinct protein subunits. Biochem. Biophys. Acta. 1072: 63-80.
15. Huxford, T., Huang, D. B., Malek, S., and Ghosh, G. (1998) The crystal structure of the IkappaB α/NF-κB complex reveals mechanism of NF-κB inactivation. Cell 95: 759-770.
16. Grimm, S. and Baeuerle, P. A. (1993) The inducible transcription factor NF-κB: structure-function relationship of its protein subunits. Biochem. J. 290 (Pt 2): 297-308.
17. Castrillo, A., de las Heras, B., Hortelano, S., Rodriguez, B., Villar, A., and Bosca, L. (2001) Inhibition of the nuclear factor-B (NF-κB) pathway by tetracyclic Kaurene diterpenes in macrophages. J. Biol. Chem. 276: 15845-15860.
18. Baeuerle, P. A. and Baltimore, D. (1998) I-κB: a specific inhibitor of the NF-κB transcription factor. Science 242: 540-546.
19. Barnes, P. J. and Karin, M. (1997) Nuclear Factor-B-a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336: 1066-1071.
20. Ryu, J. W., Seo, S. H., and Chung, S. H. (1998) Antidiabetic activity of Mori Folium ethanol soluble fraction in db/db mice. J. Pharm. Soc. Kor. 42: 613-620.
21. Kim, Y. Y., Choue, R. W., Chung, S. H., and Koo, S. J. (1999) Anti-hyperglycermic effect of cortex Mori Radix in db/db mice. Kor. J. Food Sci. Technol. 31: 1057-1064.
22. Choi, H. J., Kim, N. J., and Kim, D. H. (2000) Inhibitory effect of GE974 isolated from Gyrophora esculenta onglucosidase. Kor. J. Pharmacogn. 31: 196-202.
23. Ji, S. T., Lee, S. J., Lee, K. E., Son, Y. T., and Chung, Y. K. (2002) Inhibitory effect of extracts from Paeoniae Radix on postprandial hyperglycemia. J. Kor. Soc. Food Sci. Nutr. 31: 131-135.
24. Kim, G. H., Kim, B. S., Shin, D. B., and Jung, D. S. (2002) Screening of glucosidase inhibitors from plants. Research Report of Cheju University 16: 9-12.
25. Kahlos, K., Kangas, L., and Hitunen, R. (1987) Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus. Acta. Pharm. Fenn. 96: 33-40.
26. Ichimura, T., Watanave, O., and Maruyama, S. (1998) Inhibition of HIV-1 protease by water-soluble lignin-like substance from an edible mushroom, Fuscoporia oblique. Biosci. Biotechno. Biochem. 62: 575-577.
27. Mizuno, T., Zhuang, C., Abe, K., Okamoto, H., Kiho, T., Ukai, S., Leclerc, S., and Meijer, L. (1999) Antitumor and hypoglycemic activities of polysaccharides from the sclerotia and mycelia of Inonotus obliquus (Pre.: Fr.) Pil. (Aphyllophoromycetideae). Int. J. Med. Mushrooms 1: 301-316.
28. Moon, K. Y., Hahn, B. S., Lee, J., and Kim, Y. S. (2001) A cell-based assay system for monitoring NF-κB activity in human HaCaT transfectant cells. Anal. Biochem. 292: 17-21.
29. Moon, K. Y., Ahn, K. S., Lee, J., and Kim, Y. S. (2001) Kojic acid, a potential inhibitor of NF-κB activation in transfectant human HaCaT and SCC-13 cells. Arch. Pharm. Res. 24: 307-311.
30. Osawa, T. and Namiki, M. A. (1981) Novel type of antioxidant isolated from leaf wax of Eucalyptus leaves. Agric. Biol. Chem. 45: 735-739.
31. Miyake, Y., Yamamoto, K., and Osawa, T. (1997) Isolation of eriocitrin (eriodictyol-7-rutinoside) from lemon fruit (Citrus limon Burm. f.) and its antioxidative activity. Food Sci. Technol. Int. Tokyo. 3: 84-89.
32. Song, H. S., Ukeda, H., and Sawamura, M. (2001) Antioxidative activity of citrus peel essential oils and their components against linoleic acid oxidation. Food Sci. Technol. Res. 7: 50-56.
33. Rapisarda, P., Tomaino, A., Cascio, R. L., Bonina, F., Pasquale, A. D., and Saija, A. (1999) Antioxidant effectiveness as influenced by phenolic content of fresh orange juices. J. Agric. Food Chem. 47: 4718-4723.
34. Lee, S. M., Na, M. K., An, R. B., Min, B. S., and Lee, H. K. (2003) Antioxidant activity of two phloroglucinol derivatives from Dryopteris crassirhizoma. Biol. Pharm. Bull. 26: 1354-1356.
35. Marcocci, L., Packer, L., Dory-Lefaix, M. T., Sekaki, A., and Gards-Albert, M. (1994) Antioxidant action of Ginkgo biloba extract Egb 76. Methods Enzymol. 234: 462-475.
36. Perez, P., Page, A., and Jorcano, J. L. (2000) Role of phosphorylated p50-NF-κB in the ultraviolet response of mouse skin. Mol. Carcinog. 27: 272-279.
37. Schreck, R., Albermann, K., and Baeurel, P. A. (1992) Nuclear factor kappaB: an oxidative stress responsive transcription factor of eukaryotic cells. Free Radic. Res. Commun. 17: 221-237.
38. Suzuki, Y. J., Mizuno, M., and Packer, L. (1994) Signal transduction for nuclear factor-κB activation: proposed location of antioxidant-inhibitable step. J. Immuno. 153: 5008-5015.
39. Calfee-Mason, K. G., Spear, B. T., and Glauert, H. P. (2002) Vitamin E inhibits hepatic NF-κB activation in rats administered the hepatic tumor promoter, phenobarbital. J. Nutr. 132: 3178-3185.