Alteration of Na+ currents in dorsal root ganglion neurons from rats with a painful neuropathy

Pain

Volumn 81, Issue 1-2, 1999, Pages 15-24

  Kral, M G ^a,b   Xiong, Z ^a,b   Study, R E ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Dorsal root ganglion; Hyperalgesia; Na+ channels; Na+ currents; Nerve injury; Neuropathic pain; Pain; Sensory neurons

Indexed keywords

SODIUM CHANNEL; TETRODOTOXIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; NERVE INJURY; NEURALGIA; NEUROPATHY; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SODIUM CURRENT; SPINAL GANGLION;

ANIMALS; CONSTRICTION, PATHOLOGIC; DRUG RESISTANCE; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; GANGLIA, SPINAL; MALE; NERVOUS SYSTEM DISEASES; NEURONS; PAIN; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; TETRODOTOXIN;

EID: 0032951898     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00264-4     Document Type: Article

References (36)

1. Akopian A.N., Sivilotti L., Wood J.N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature. 379:1996;257-262.
2. Armstrong C.M., Chow R.H. Supercharging: a method for improving patch-clamp performance. Biophys. J. 52:1987;133-136.
3. Baccaglini P.I., Hogan P.G. Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells. Proc. Natl. Acad. Sci. USA. 80:1983;594-598.
4. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:1988;87-107.
5. Benzanilla F., Armstrong C.M. Inactivation of the sodium channel. I. Sodium current experiments, J. Gen. Physiol. 70:1977;549-566.
6. Caffrey J.M., Eng D.L., Black J.A., Waxman S.G., Kocsis J.D. Three types of sodium channels in adult rat dorsal root ganglion neurons. Brain Res. 592:1992;283-297.
7. Clatworthy A.L., Illich P.A., Castro G.A., Walters E.T. Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain. Neurosci. Lett. 184:1995;5-8.
8. Coggeshall R.E., Dougherty P.M., Pover C.M., Carlton S.M. Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat? Pain. 52:1993;233-242.
9. Cummins T.R., Waxman S.G. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J Neurosci. 17:1997;3503-3514.
10. DeLeo J.A., Coombs D.W., Willenbring S., Colburn R.W., Fromm C., Wagner R., Twitchell B.B. Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat. Pain. 56:1994;9-16.
11. Devor, M., The pathophysiology of damaged peripheral nerves. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1994, pp. 79-100.
12. Elliott A.A., Elliott J.R. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol. (Lond.). 463:1993;39-56.
13. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J. Physiol. (Lond.). 495:1996;429-440.
14. Ferreira S.H., Lorenzetti B.B., De Campos D.I. Induction, blockade and restoration of a persistent hypersensitive state. Pain. 42:1990;365-371.
15. Gold M.S., Reichling D.B., Shuster M.J., Levine J.D. Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors, Proc. Natl. Acad. Sci. USA. 93:1996;1108-1112.
16. Gracely R.H., Lynch S.A., Bennett G.J. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain. 51:1992;175-194.
17. Harper A.A., Lawson S.N. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J. Physiol. (Lond.). 359:1985;31-46.
18. Kajander K.C., Bennett G.J. Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J. Neurophysiol. 68:1992;734-744.
19. Kajander K.C., Wakisaka S., Bennett G.J. Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat. Neurosci. Lett. 138:1992;225-228.
20. Kim S.H., Chung J.M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:1992;355-363.
21. Koltzenberg, M., Kees, S., Budweiser, S., Ochs, G. and Toyka, K., The properties of unmyelinated nociceptive afferents change in a painful chronic constriction neruopathy. In: G.F. Gebhart, D.L. Hammond and T.S. Jensen (Eds.), Progress in Pain Research and Management: Proceedings of the 7th World Congress on Pain, Vol. 2, IASP Press, Seattle, WA, 1994, pp. 511-522.
22. 2+. J. Physiol. (Lond.). 430:1990;159-188.
23. Novakovic S.D., Tzoumaka E., McGivern J.G., Haraguchi M., Sangameswaran L., Gogas K.R., Eglen R.M., Hunter J.C. Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J. Neurosci. 18:1998;2174-2187.
24. Nystrom B., Hagbarth K.E. Microelectrode recordings from transected nerves in amputees with phantom limb pain. Neurosci. Lett. 27:1981;211-216.
25. + channels in rat dorsal root ganglia. J. Physiol. (Lond.). 466:1993;9-37.
26. Petersen M., Zhang J., Zhang J.M., Lamotte R.H. Abnormal spontaneous activity and responses to norepinephrine indissociated dorsal root ganglion cells after chronic nerve constriction. Pain. 67:1996;391-397.
27. + currents in cutaneous afferent dorsal root ganglion neurons following axotomy. Neurobiol. Dis. 2:1995;87-96.
28. Sangameswaran L., Fish L.M., Koch B.D., Rabert D.K., Delgado S.G., Ilnicka M., Jakeman L.B., Novakovic S., Wong K., Sze P., Tzoumaka E., Stewart G.R., Herman R.C., Chan H., Eglen R.M., Hunter J.C. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. J. Biol. Chem. 272:1997;14805-14809.
29. Sommer C., Lalonde A., Heckman H.M., Rodriguez M., Myers R.R. Quantitative neuropathology of a focal nerve injury causing hyperalgesia. J. Neuropath. Exp. Neurol. 54:1995;635-643.
30. Study R.E., Kral M.G. Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy. Pain. 65:1996;235-242.
31. Vos B.P., Strassman A.M., Maciewicz R.J. Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve. J. Neurosci. 14:1994;2708-27023.
32. Waxman S.G., Kocsis J.D., Black J.A. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J. Neurophysiol. 72:1994;466-470.
33. A receptors of dorsal root ganglion neurons freshly dissociated from adult rats. Synapse. 11:1992;259-266.
34. Xiao, W. and Xie, Y., Dynamic changes in abnormal afferent activities following peripheral nerve injury [Chinese], Chung Kuo i Hsueh Ko Hsueh Yuan Hsueh Pao, 12 (1990) 110-114.
35. Xie Y., Zhang J., Petersen M., LaMotte R.H. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat. J. Neurophysiol. 73:1995;1811-1820.
36. Zhang J., Donelly D., Song X.-J., LaMotte R. Increased excitability of dorsal root ganglion cells with unmyelinated axons after axotomy. Soc. Neurosci. Abstr. 23:1997;1259.