메뉴 건너뛰기




Volumn 287, Issue 1-2, 2004, Pages 203-215

Expression of the B subunit of the heat-labile enterotoxin of Escherichia coli in tobacco mosaic virus-infected Nicotiana benthamiana plants and its characterization as mucosal immunogen and adjuvant

Author keywords

5 bromo 4 chloro 3 indolylphosphate; BCIP; Bovine serum albumin; BSA; Cholera toxin; Con A; Concanavalin A; CT; ELISA; Latex allergen Hev b 3; Mouse model; Mucosal adjuvant; Nicotiana benthamiana; Recombinant LTB; Tobacco mosaic virus expression vector

Indexed keywords

ALLERGEN; BACTERIAL PROTEIN; ENTEROTOXIN; GANGLIOSIDE GM1; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOLOGICAL ADJUVANT; LATEX; RECOMBINANT DNA; VIRUS DNA; VIRUS VECTOR;

EID: 1942488293     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2004.02.001     Document Type: Article
Times cited : (31)

References (49)
  • 1
    • 0031281621 scopus 로고    scopus 로고
    • Expression of cholera toxin B subunit oligomers in transgenic potato plants
    • Arakawa T., Chong D.K., Merritt J.L., Langridge W.H. Expression of cholera toxin B subunit oligomers in transgenic potato plants. Transgenic Res. 6:1997;403.
    • (1997) Transgenic Res. , vol.6 , pp. 403
    • Arakawa, T.1    Chong, D.K.2    Merritt, J.L.3    Langridge, W.H.4
  • 2
    • 0027173924 scopus 로고
    • Oral immunization with Toxoplasma gondii antigens in association with cholera toxin induces enhanced protective and cell-mediated immunity in C57BL/6 mice
    • Bourguin I., Chardes T., Bout D. Oral immunization with Toxoplasma gondii antigens in association with cholera toxin induces enhanced protective and cell-mediated immunity in C57BL/6 mice. Infect. Immun. 61:1993;2082.
    • (1993) Infect. Immun. , vol.61 , pp. 2082
    • Bourguin, I.1    Chardes, T.2    Bout, D.3
  • 3
    • 0020638916 scopus 로고
    • Cloning and molecular characterization of the B subunit of Escherichia coli heat-labile enterotoxin
    • Clements J.D., Flint D.C., Engert R.F., Klipstein F.A. Cloning and molecular characterization of the B subunit of Escherichia coli heat-labile enterotoxin. Infect. Immun. 40:1983;653.
    • (1983) Infect. Immun. , vol.40 , pp. 653
    • Clements, J.D.1    Flint, D.C.2    Engert, R.F.3    Klipstein, F.A.4
  • 4
    • 0023938398 scopus 로고
    • Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens
    • Clements J.D., Hartzog N.M., Lyon F.L. Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens. Vaccine. 6:1988;269.
    • (1988) Vaccine , vol.6 , pp. 269
    • Clements, J.D.1    Hartzog, N.M.2    Lyon, F.L.3
  • 5
    • 0031842147 scopus 로고    scopus 로고
    • The role of ADP-ribosylation and G(M1)-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coli heat-labile enterotoxin and Vibrio cholerae cholera toxin
    • de Haan L., Verweij W., Agsteribbe E., Wilschut J. The role of ADP-ribosylation and G(M1)-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coli heat-labile enterotoxin and Vibrio cholerae cholera toxin. Immunol. Cell Biol. 76:1998;270.
    • (1998) Immunol. Cell Biol. , vol.76 , pp. 270
    • De Haan, L.1    Verweij, W.2    Agsteribbe, E.3    Wilschut, J.4
  • 6
    • 0031595032 scopus 로고    scopus 로고
    • Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat-labile enterotoxin and its B subunit
    • de Haan L., Verweij W.R., Feil I.K., Holtrop M., Hol W.G., Agsteribbe E., Wilschut J. Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat-labile enterotoxin and its B subunit. Immunology. 94:1998;424.
    • (1998) Immunology , vol.94 , pp. 424
    • De Haan, L.1    Verweij, W.R.2    Feil, I.K.3    Holtrop, M.4    Hol, W.G.5    Agsteribbe, E.6    Wilschut, J.7
  • 8
    • 0030940814 scopus 로고    scopus 로고
    • Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin
    • Douce G., Fontana M., Pizza M., Rappuoli R., Dougan G. Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin. Infect. Immun. 65:1997;2821.
    • (1997) Infect. Immun. , vol.65 , pp. 2821
    • Douce, G.1    Fontana, M.2    Pizza, M.3    Rappuoli, R.4    Dougan, G.5
  • 9
    • 0031802314 scopus 로고    scopus 로고
    • Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli
    • Douce G., Giuliani M.M., Giannelli V., Pizza M.G., Rappuoli R., Dougan G. Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli. Vaccine. 16:1998;1065.
    • (1998) Vaccine , vol.16 , pp. 1065
    • Douce, G.1    Giuliani, M.M.2    Giannelli, V.3    Pizza, M.G.4    Rappuoli, R.5    Dougan, G.6
  • 10
    • 0021260553 scopus 로고
    • Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin
    • Elson C.O., Ealding W. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J. Immunol. 132:1984;2736.
    • (1984) J. Immunol. , vol.132 , pp. 2736
    • Elson, C.O.1    Ealding, W.2
  • 11
    • 0034767238 scopus 로고    scopus 로고
    • Rotavirus 2/6 virus-like particles administered intranasally in mice, with or without the mucosal adjuvants cholera toxin and Escherichia coli heat-labile toxin, induce a Th1/Th2-like immune response
    • Fromantin C., Jamot B., Cohen J., Piroth L., Pothier P., Kohli E. Rotavirus 2/6 virus-like particles administered intranasally in mice, with or without the mucosal adjuvants cholera toxin and Escherichia coli heat-labile toxin, induce a Th1/Th2-like immune response. J. Virol. 75:2001;11010.
    • (2001) J. Virol. , vol.75 , pp. 11010
    • Fromantin, C.1    Jamot, B.2    Cohen, J.3    Piroth, L.4    Pothier, P.5    Kohli, E.6
  • 12
    • 0017288465 scopus 로고
    • Mechanism of activation of adenylate cyclase in vitro by polymyxin-released, heat-labile enterotoxin of Escherichia coli
    • (Suppl.)
    • Gill D.M., Evan D.J. Jr., Evans D.G. Mechanism of activation of adenylate cyclase in vitro by polymyxin-released, heat-labile enterotoxin of Escherichia coli. J. Infect. Dis. 133:1976;103. (Suppl.).
    • (1976) J. Infect. Dis. , vol.133 , pp. 103
    • Gill, D.M.1    Evan, D.J.Jr.2    Evans, D.G.3
  • 13
    • 0029055060 scopus 로고
    • Oral immunization with a recombinant bacterial antigen produced in transgenic plants
    • Haq T.A., Mason H.S., Clements J.D., Arntzen C.J. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science. 268:1995;714.
    • (1995) Science , vol.268 , pp. 714
    • Haq, T.A.1    Mason, H.S.2    Clements, J.D.3    Arntzen, C.J.4
  • 14
    • 0023449557 scopus 로고
    • Conformation of protein secreted across bacterial outer membranes: A study of enterotoxin translocation from Vibrio cholerae
    • Hirst T.R., Holmgren J. Conformation of protein secreted across bacterial outer membranes: a study of enterotoxin translocation from Vibrio cholerae. Proc. Natl. Acad. Sci. U. S. A. 84:1987;7418.
    • (1987) Proc. Natl. Acad. Sci. U. S. A. , vol.84 , pp. 7418
    • Hirst, T.R.1    Holmgren, J.2
  • 15
    • 0019852740 scopus 로고
    • Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes
    • Kozak M. Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res. 9:1981;5233.
    • (1981) Nucleic Acids Res. , vol.9 , pp. 5233
    • Kozak, M.1
  • 16
    • 0033949742 scopus 로고    scopus 로고
    • Rapid production of the major birch pollen allergen Bet v 1 in Nicotiana benthamiana plants and its immunological in vitro and in vivo characterization
    • Krebitz M., Wiedermann U., Essl D., Steinkellner H., Wagner B., Turpen T.H., Ebner C., Scheiner O., Breiteneder H. Rapid production of the major birch pollen allergen Bet v 1 in Nicotiana benthamiana plants and its immunological in vitro and in vivo characterization. FASEB J. 14:2000;1279.
    • (2000) FASEB J. , vol.14 , pp. 1279
    • Krebitz, M.1    Wiedermann, U.2    Essl, D.3    Steinkellner, H.4    Wagner, B.5    Turpen, T.H.6    Ebner, C.7    Scheiner, O.8    Breiteneder, H.9
  • 19
    • 0036572321 scopus 로고    scopus 로고
    • Expression and purification of a neuropeptide nocistatin using two related plant viral vectors
    • Lim A.A., Tachibana S., Watanabe Y., Wong S.M. Expression and purification of a neuropeptide nocistatin using two related plant viral vectors. Gene. 289:2002;69.
    • (2002) Gene , vol.289 , pp. 69
    • Lim, A.A.1    Tachibana, S.2    Watanabe, Y.3    Wong, S.M.4
  • 20
    • 0026699224 scopus 로고
    • The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity
    • Lycke N., Tsuji T., Holmgren J. The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity. Eur. J. Immunol. 22:1992;2277.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2277
    • Lycke, N.1    Tsuji, T.2    Holmgren, J.3
  • 22
    • 0032146489 scopus 로고    scopus 로고
    • Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene
    • Mason H.S., Haq T.A., Clements J.D., Arntzen C.J. Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine. 16:1998;1336.
    • (1998) Vaccine , vol.16 , pp. 1336
    • Mason, H.S.1    Haq, T.A.2    Clements, J.D.3    Arntzen, C.J.4
  • 24
    • 0035063575 scopus 로고    scopus 로고
    • Escherichia coli heat-labile enterotoxin B subunit is a more potent mucosal adjuvant than its vlosely related homologue, the B subunit of cholera toxin
    • Millar D.G., Hirst T.R., Snider D.P. Escherichia coli heat-labile enterotoxin B subunit is a more potent mucosal adjuvant than its vlosely related homologue, the B subunit of cholera toxin. Infect. Immun. 69:2001;3476.
    • (2001) Infect. Immun. , vol.69 , pp. 3476
    • Millar, D.G.1    Hirst, T.R.2    Snider, D.P.3
  • 25
    • 0023652396 scopus 로고
    • A C-terminal signal prevents secretion of luminal ER proteins
    • Munro S., Pelham H.R. A C-terminal signal prevents secretion of luminal ER proteins. Cell. 48:1987;899.
    • (1987) Cell , vol.48 , pp. 899
    • Munro, S.1    Pelham, H.R.2
  • 26
    • 0030030530 scopus 로고    scopus 로고
    • Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets
    • Nashar T.O., Webb H.M., Eaglestone S., Williams N.A., Hirst T.R. Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets. Proc. Natl. Acad. Sci. U. S. A. 93:1996;226.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 226
    • Nashar, T.O.1    Webb, H.M.2    Eaglestone, S.3    Williams, N.A.4    Hirst, T.R.5
  • 28
    • 0002370801 scopus 로고    scopus 로고
    • Tobamovirus transient expression vectors: Tools for plant biology and high-level expression of foreign proteins in plants
    • S.B. Gelvin, & R.A. Schilperoort. Dordrecht, The Netherlands: Kluwer Academic Publishers
    • Pogue G.P., Lindbo J.A., Dawson W.O., Turpen T.H. Tobamovirus transient expression vectors: tools for plant biology and high-level expression of foreign proteins in plants. Gelvin S.B., Schilperoort R.A. Plant Molecular Biology Manual. 1998;1 Kluwer Academic Publishers, Dordrecht, The Netherlands.
    • (1998) Plant Molecular Biology Manual , pp. 1
    • Pogue, G.P.1    Lindbo, J.A.2    Dawson, W.O.3    Turpen, T.H.4
  • 29
    • 0026014655 scopus 로고
    • Similar subclass antibody responses after intranasal immunization with UV-inactivated RSV mixed with cholera toxin or live RSV
    • Reuman P.D., Keely S.P., Schiff G.M. Similar subclass antibody responses after intranasal immunization with UV-inactivated RSV mixed with cholera toxin or live RSV. J. Med. Virol. 35:1991;192.
    • (1991) J. Med. Virol. , vol.35 , pp. 192
    • Reuman, P.D.1    Keely, S.P.2    Schiff, G.M.3
  • 31
    • 0028228375 scopus 로고
    • Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin
    • Snider D.P., Marshall J.S., Perdue M.H., Liang H. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 153:1994;647.
    • (1994) J. Immunol. , vol.153 , pp. 647
    • Snider, D.P.1    Marshall, J.S.2    Perdue, M.H.3    Liang, H.4
  • 32
  • 33
    • 0025312989 scopus 로고
    • Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5
    • Taguchi T., McGhee J.R., Coffman R.L., Beagley K.W., Eldridge J.H., Takatsu K., Kiyono H. Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5. J. Immunol. 145:1990;68.
    • (1990) J. Immunol. , vol.145 , pp. 68
    • Taguchi, T.1    McGhee, J.R.2    Coffman, R.L.3    Beagley, K.W.4    Eldridge, J.H.5    Takatsu, K.6    Kiyono, H.7
  • 35
    • 0028169640 scopus 로고
    • Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine
    • Tamura S., Asanuma H., Tomita T., Komase K., Kawahara K., Danbara H., Hattori N., Watanabe K., Suzuki Y., Nagamine T.et al. Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine. Vaccine. 12:1994;1083.
    • (1994) Vaccine , vol.12 , pp. 1083
    • Tamura, S.1    Asanuma, H.2    Tomita, T.3    Komase, K.4    Kawahara, K.5    Danbara, H.6    Hattori, N.7    Watanabe, K.8    Suzuki, Y.9    Nagamine, T.10
  • 36
    • 0027964658 scopus 로고
    • Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin
    • Tamura S., Shoji Y., Hasiguchi K., Aizawa C., Kurata T. Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin. Vaccine. 12:1994;1238.
    • (1994) Vaccine , vol.12 , pp. 1238
    • Tamura, S.1    Shoji, Y.2    Hasiguchi, K.3    Aizawa, C.4    Kurata, T.5
  • 37
    • 0031986238 scopus 로고    scopus 로고
    • Recombinant cholera toxin B subunit acts as an adjuvant for the mucosal and systemic responses of mice to mucosally co-administered bovine serum albumin
    • Tochikubo K., Isaka M., Yasuda Y., Kozuka S., Matano K., Miura Y., Taniguchi T. Recombinant cholera toxin B subunit acts as an adjuvant for the mucosal and systemic responses of mice to mucosally co-administered bovine serum albumin. Vaccine. 16:1998;150.
    • (1998) Vaccine , vol.16 , pp. 150
    • Tochikubo, K.1    Isaka, M.2    Yasuda, Y.3    Kozuka, S.4    Matano, K.5    Miura, Y.6    Taniguchi, T.7
  • 39
    • 0032219522 scopus 로고    scopus 로고
    • Mucosal immunoadjuvant activity of recombinant Escherichia coli heat-labile enterotoxin and its B subunit: Induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with influenza virus surface antigen
    • Verweij W.R., de Haan L., Holtrop M., Agsteribbe E., Brands R., van Scharrenburg G.J., Wilschut J. Mucosal immunoadjuvant activity of recombinant Escherichia coli heat-labile enterotoxin and its B subunit: induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with influenza virus surface antigen. Vaccine. 16:1998;2069.
    • (1998) Vaccine , vol.16 , pp. 2069
    • Verweij, W.R.1    De Haan, L.2    Holtrop, M.3    Agsteribbe, E.4    Brands, R.5    Van Scharrenburg, G.J.6    Wilschut, J.7
  • 40
    • 0001119456 scopus 로고    scopus 로고
    • Cloning, expression, and characterization of recombinant Hev b 3, a Hevea brasiliensis protein associated with latex allergy in patients with spina bifida
    • Wagner B., Krebitz M., Buck D., Niggemann B., Yeang H.Y., Han K.H., Scheiner O., Breiteneder H. Cloning, expression, and characterization of recombinant Hev b 3, a Hevea brasiliensis protein associated with latex allergy in patients with spina bifida. J. Allergy Clin. Immunol. 104:1999;1084.
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 1084
    • Wagner, B.1    Krebitz, M.2    Buck, D.3    Niggemann, B.4    Yeang, H.Y.5    Han, K.H.6    Scheiner, O.7    Breiteneder, H.8
  • 43
    • 0031929609 scopus 로고    scopus 로고
    • Effects of adjuvants on the immune response to allergens in a murine model of allergen inhalation: Cholera toxin induces a Th1-like response to Bet v 1, the major birch pollen allergen
    • Wiedermann U., Jahn-Schmid B., Fritsch R., Bauer L., Renz H., Kraft D., Ebner C. Effects of adjuvants on the immune response to allergens in a murine model of allergen inhalation: cholera toxin induces a Th1-like response to Bet v 1, the major birch pollen allergen. Clin. Exp. Immunol. 111:1998;144.
    • (1998) Clin. Exp. Immunol. , vol.111 , pp. 144
    • Wiedermann, U.1    Jahn-Schmid, B.2    Fritsch, R.3    Bauer, L.4    Renz, H.5    Kraft, D.6    Ebner, C.7
  • 44
    • 0032836876 scopus 로고    scopus 로고
    • Suppression of antigen-specific T-and B-cell responses by intranasal or oral administration of recombinant Bet v 1, the major birch pollen allergen, in a murine model of type I allergy
    • Wiedermann U., Jahn-Schmid B., Bohle B., Repa A., Renz H., Kraft D., Ebner C. Suppression of antigen-specific T-and B-cell responses by intranasal or oral administration of recombinant Bet v 1, the major birch pollen allergen, in a murine model of type I allergy. J. Allergy Clin. Immunol. 103:1999;1202.
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 1202
    • Wiedermann, U.1    Jahn-Schmid, B.2    Bohle, B.3    Repa, A.4    Renz, H.5    Kraft, D.6    Ebner, C.7
  • 45
    • 0033753162 scopus 로고    scopus 로고
    • Immune modulation by the cholera-like enterotoxin B-subunits: From adjuvant to immunotherapeutic
    • Williams N.A. Immune modulation by the cholera-like enterotoxin B-subunits: from adjuvant to immunotherapeutic. Int. J. Med. Microbiol. 290:2000;447.
    • (2000) Int. J. Med. Microbiol. , vol.290 , pp. 447
    • Williams, N.A.1
  • 46
    • 0036124728 scopus 로고    scopus 로고
    • Mucosal tolerance as therapy of type I allergy: Intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice
    • Winkler B., Baier K., Wagner S., Repa A., Eichler H.G., Scheiner O., Kraft D., Wiedermann U. Mucosal tolerance as therapy of type I allergy: intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice. Clin. Exp. Allergy. 32:2002;30.
    • (2002) Clin. Exp. Allergy , vol.32 , pp. 30
    • Winkler, B.1    Baier, K.2    Wagner, S.3    Repa, A.4    Eichler, H.G.5    Scheiner, O.6    Kraft, D.7    Wiedermann, U.8
  • 47
    • 0027183310 scopus 로고
    • Helper T cell subsets for immunoglobulin a responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
    • Xu-Amano J., Kiyono H., Jackson R.J., Staats H.F., Fujihashi K., Burrows P.D., Elson C.O., Pillai S., McGhee J.R. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Exp. Med. 178:1993;1309.
    • (1993) J. Exp. Med. , vol.178 , pp. 1309
    • Xu-Amano, J.1    Kiyono, H.2    Jackson, R.J.3    Staats, H.F.4    Fujihashi, K.5    Burrows, P.D.6    Elson, C.O.7    Pillai, S.8    McGhee, J.R.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.