Kinetic and mechanistic analyses of new classes of inhibitors of two-component signal transduction systems using a coupled assay containing HpkA-DrrA from Thermotoga maritima

Microbiology

Volumn 150, Issue 4, 2004, Pages 885-896

  Foster, J Estelle ^a,c   Sheng, Qin ^a   McClain, Jonathan R ^a   Bures, Mark ^a   Nicas, Thalia I ^a,d   Henry, Kenneth ^a   Winkler, Malcolm E ^a,b,e   Gilmour, Raymond ^a  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c MDS Proteomics Inc   (Canada)

^d Lilly Technology Center   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; ANTIBIOTIC AGENT; CLOSANTEL; ETHACRIDINE LACTATE; PEPTIDE; PROTEIN DRRA; PROTEIN HISTIDINE KINASE; PROTEIN INHIBITOR; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL SURVIVAL; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; HYDROPHOBICITY; IC 50; MINIMUM INHIBITORY CONCENTRATION; MUKAIYAMA MICHAEL REACTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; THERMOTOGA MARITIMA;

BACTERIA (MICROORGANISMS); THERMOTOGA; THERMOTOGA MARITIMA;

EID: 1942441039     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.26824-0     Document Type: Article

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