Vancomycin tolerance induced by erythromycin but not by loss of vncRS, vex3, or pep27 function in Streptococcus pneumoniae

Journal of Bacteriology

Volumn 184, Issue 24, 2002, Pages 6987-7000

  Robertson, Gregory T ^a   Zhao, Jingyong ^a   Desai, Bhushan V ^b   Coleman, William H ^b   Nicas, Thalia I ^a   Gilmour, Raymond ^a   Grinius, Leo ^c   Morrison, Donald A ^b   Winkler, Malcolm E ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; ERYTHROMYCIN; VANCOMYCIN;

ARTICLE; AUTOLYSIS; BACTERIAL GROWTH; BACTERIAL MUTATION; BACTERIAL STRAIN; DRUG EFFECT; DRUG TOLERABILITY; GENE CLUSTER; GENE CONTROL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; AUTOLYSIS; BACTERIAL PROTEINS; BASE SEQUENCE; ERYTHROMYCIN; FEMALE; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN KINASES; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION FACTORS; VANCOMYCIN RESISTANCE;

ANIMALIA; BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 0036956990     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.184.24.6987-7000.2002     Document Type: Article

References (47)

1. Anton, N., R. Blazquez, J. L. Gomez-Garces, and J. I. Alos. 2001. Study of vancomycin tolerance in 120 strains of Streptococcus pneumoniae isolated in 1999 in Madrid, Spain. J. Antimicrob. Chemother. 47:902-903.
2. Baltz, R. H., F. H. Norris, P. Matsushima, B. S. Dehoff, P. Rockey, G. Porter, S. Burgett, R. B. Peery, J. Hoskins, L. Braverman, I. Jenkins, P. Solenberg, M. Young, M. A. McHenney, P. R. Rosteck, Jr., and P. L. Skatrud. 2000. DNA sequence sampling and gene disruption for identification of new antibacterial targets in Streptococcus pneumoniae, p. 33-44. In A. Tomasz (ed.), Streptococcus pneumoniae: molecular biology and mechanisms of disease. Mary Ann Liebert, Inc., Larchmont, N.Y.
3. Berge, M., P. Garcia, F. Iannelli, M. F. Prere, C. Granadel, A. Polissi, and J. P. Claverys. 2001. The puzzle of zmpB and extensive chain formation, autolysis defect and non-translocation of choline-binding proteins in Streptococcus pneumoniae. Mol. Microbiol. 39:1651-1660.
4. Charpentier, E., R. Novak, and E. Tuomanen. 2000. Regulation of growth inhibition at high temperature, autolysis, transformation and adherence in Streptococcus pneumoniae by clpC. Mol. Microbiol. 37:717-726.
5. Chastanet, A., M. Prudhomme, J. P. Claverys, and T. Msadek. 2001. Regulation of Streptococcus pneumoniae clp genes and their role in competence development and stress survival. J. Bacteriol. 183:7295-7307.
6. Claverys, J. P., A. Dintilhac, E. V. Pestova, B. Martin, and D. A. Morrison. 1995. Construction and evaluation of new drug-resistance cassettes for gene disruption mutagenesis in Streptococcus pneumoniae, using an ami test platform. Gene 164:123-128.
7. Claverys, J. P., C. Granadel, A. M. Berry, and J. C. Paton. 1999. Penicillin tolerance in Streptococcus pneumoniae, autolysis and the Psa ATP-binding cassette (ABC) manganese permease. Mol. Microbiol. 32:881-883.
8. de Saizieu, A., C. Gardes, N. Flint, C. Wagner, M. Kamber, T. J. Mitchell, W. Keck, K. E. Amrein, and R. Lange. 2000. Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide. J. Bacteriol. 182:4696-4703.
9. Filipe, S. R., E. Severina, and A. Tomasz. 2002. The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA 99:1550-1555.
10. Henriques Normark, B., R. Novak, A. Ortqvist, G. Kallenius, E. Tuomanen, and S. Normark. 2001. Clinical isolates of Streptococcus pneumoniae that exhibit tolerance of vancomycin. Clin. Infect. Dis. 32:552-558.
11. Hooper, D. C. 2001. Mechanisms of action of antimicrobials: focus on fluoroquinolones. Clin. Infect. Dis. 32(Suppl. 1):S9-S15.
12. Hoskins, J., W. E. Alborn, Jr., J. Arnold, L. C. Blaszczak, S. Burgett, B. S. DeHoff, S. T. Estrem, L. Fritz, D. J. Fu, W. Fuller, C. Geringer, R. Gilmour, J. S. Glass, H. Khoja, A. R. Kraft, R. E. Lagace, D. J. LeBlanc, L. N. Lee, E. J. Lefkowitz, J. Lu, P. Matsushima, S. M. McAhren, M. McHenney, K. McLeaster, C. W. Mundy, T. I. Nicas, F. H. Norris, M. O'Gara, R. B. Peery, G. T. Robertson, P. Rockey, P. M. Sun, M. E. Winkler, Y. Yang, M. Young-Bellido, G. Zhao, C. A. Zook, R. H. Baltz, S. R. Jaskunas, P. R. Rosteck, Jr., P. L. Skatrud, and J. I. Glass. 2001. Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. 183:5709-5717.
13. Klugman, K. P., and C. Feldman. 2001. Streptococcus pneumoniae respiratory tract infections. Curr. Opin. Infect. Dis. 14:173-179.
14. Lacks, S., and R. D. Hotchkiss. 1960. A study of the genetic material determining an enzyme activity in pneumococcus. Biochim. Biophys. Acta 39:508-518.
15. Lau, P. C., C. K. Sung, J. H. Lee, D. A. Morrison, and D. G. Cvitkovitch. 2002. PCR ligation mutagenesis in transformable streptococei: application and efficiency. J. Microbiol. Methods 49:193-205.
16. LeBlanc, D. J., L. N. Lee, and A. Abu-Al-Jaibat. 1992. Molecular, genetic, and functional analysis of the basic replicon of pVA380-1, a plasmid of oral streptococcal origin. Plasmid 28:130-145.
17. Lee, M. S., and D. A. Morrison. 1999. Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation. J. Bacteriol. 181:5004-5016.
18. Macrina, F. L., J. A. Tobian, K. R. Jones, R. P. Evans, and D. B. Clewell. 1982. A cloning vector able to replicate in Escherichia coli and Streptococcus sanguis. Gene 19:345-353.
19. Matsushita, M., and K. D. Janda. 2002. Histidine kinases as targets for new antimicrobial agents. Bioorg. Med. Chem. 10:855-867.
20. McCullers, J. A., B. K. English, and R. Novak. 2000. Isolation and characterization of vancomycin-tolerant Streptococcus pneumoniae from the cerebrospinal fluid of a patient who developed recrudescent meningitis. J. Infect. Dis. 181:369-373.
21. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratories, Cold Spring Harbor, N.Y.
22. Mitchell, L., and E. Tuomanen. 2001. Vancomycin-tolerant Streptococcus pneumoniae and its clinical significance. Pediatr. Infect. Dis. J. 20:531-533.
23. Moreillon, P., and A. Tomasz. 1988. Penicillin resistance and defective lysis in clinical isolates of pneumococci: evidence for two kinds of antibiotic pressure operating in the clinical environment. J. Infect. Dis. 157:1150-1157.
24. Morrison, D. A., S. A. Lacks, W. R. Guild, and J. M. Hageman. 1983. Isolation and characterization of three new classes of transformation-deficient mutants of Streptococcus pneumoniae that are defective in DNA transport and genetic recombination. J. Bacteriol. 156:281-290.
25. National Research Council. 1985., Guide for the care and use of laboratory animals. NIH publication no. 86-23. National Institutes of Health, Bethesda, Md.
26. Novak, R., J. S. Braun, E. Charpentier, and E. Tuomanen. 1998. Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex Psa. Mol. Microbiol. 29:1285-1296.
27. Novak, R., E. Charpentier, J. S. Braun, E. Park, S. Murti, E. Tuomanen, and R. Masure. 2000. Extracellular targeting of choline-binding proteins in Streptococcuspneumoniae by a zinc metalloprotease. Mol. Microbiol. 36:366-376.
28. Novak, R., E. Charpentier, J. S. Braun, and E. Tuomanen. 2000. Signal transduction by a death signal peptide: uncovering the mechanism of bacterial killing by penicillin. Mol. Cell 5:49-57.
29. Novak, R., B. Henriques, E. Charpentier, S. Normark, and E. Tuomanen. 1999. Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature 399:590-593.
30. Pestova, E. V., and D. A. Morrison. 1998. Isolation and characterization of three Streptococcus pneumoniae transformation-specific loci by use of a lacZ reporter insertion vector. J. Bacteriol. 180:2701-2710.
31. Peterson, S., R. T. Cline, H. Tettelin, V. Sharov, and D. A. Morrison. 2000. Gene expression analysis of the Streptococcus pneumoniae competence regulons by use of DNA microarrays. J. Bacteriol. 182:6192-6202.
32. Pozzi, G., L. Masala, F. Iannelli, R. Manganelli, L. S. Havarstein, L. Piccoli, D. Simon, and D. A. Morrison. 1996. Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone. J. Bacteriol. 178:6087-6090.
33. Reese, R. E., R. F. Betts, and B. Gumustop. 2000. Handbook of antibiotics, 3rd ed. Lippincott, Williams & Wilkins, Philadelphia, Pa.
34. Reichmann, P., and R. Hakenbeck. 2000. Allelic variation in a peptide-inducible hvo-component system of Streptococcus pneumoniae. FEMS Microbiol. Lett. 190:231-236.
35. Rimini, R., B. Jansson, G. Feger, T. C. Roberts, M. de Francesco, A. Gozzi, F. Faggioni, E. Domenici, D. M. Wallace, N. Frandsen, and A. Polissi. 2000. Global analysis of transcription kinetics during competence development in Streptococcus pneumoniae using high density DNA arrays. Mol. Microbiol. 36:1279-1292.
36. Robertson, G. T., W.-L. Ng, J. Foley, R. Gilmour, and M. E. Winkler. 2002. Global transcriptional analysis of clpP mutations of type 2 Streptococcus pneumoniae and their effects on physiology and virulence. J. Bacteriol. 184: 3508-3520.
37. Smith, M. D., and W. R. Guild. 1979. A plasmid in Streptococcus pneumoniae. J. Bacteriol. 137:735-739.
38. Stock, A. M., V. L. Robinson, and P. N. Goudreau. 2000. Two-component signal transduction. Annu. Rev. Biochem. 69:183-215.
39. Sung, C. K., H. Li, J. P. Claverys, and D. A. Morrison. 2001. An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae. Appl. Environ. Microbiol. 67:5190-5196.
40. Talkington, D. F., D. C. Voellinger, L. S. McDaniel, and D. E. Briles. 1992. Analysis of pneumococcal PspA microheterogeneity in SDS polyacrylamide gels and the association of PspA with the cell membrane. Microb. Pathog. 13:343-355.
41. Throup, J. P., K. K. Koretke, A. P. Bryant, K. A. Ingraham, A. F. Chalker, Y. Ge, A. Marra, N. G. Wallis, J. R. Brown, D. J. Holmes, M. Rosenberg, and M. K. Burnham. 2000. A genomic analysis of two-component signal transduction in Streptococcus pneumoniae. Mol. Microbiol. 35:566-576.
42. Tomasz, A. 1999. New faces of an old pathogen: emergence and spread of multidrug-resistant Streptococcus pneumoniae. Am. J. Med. 107:55S-62S.
43. Tomasz, A., A. Albino, and E. Zanati. 1970. Multiple antibiotic resistance in a bacterium with suppressed autolytic system. Nature 227:138-140.
44. Tuomanen, E., H. Pollack, A. Parkinson, M. Davidson, R. Facklam, R. Rich, and O. Zak. 1988. Microbiological and clinical significance of a new property of defective lysis in clinical strains of pneumococci. J. Infect. Dis. 158:36-43.
45. Vogelman, B., S. Gudmundsson, J. Turnidge, J. Leggett, and W. A. Craig. 1988. In vivo postantibiotic effect in a thigh infection in neutropenic mice. J. Infect. Dis. 157:287-298.
46. Williamson, R., and A. Tomasz. 1980. Antibiotic-tolerant mutants of Streptococcus pneumoniae that are not deficient in autolytic activity. J. Bacteriol. 144:105-113.
47. Zahner, D., and R. Hakenbeck. 2000. The Streptococcus pneumoniae betagalactosidase is a surface protein. J. Bacteriol. 182:5919-5921.