Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element

Biochemical and Biophysical Research Communications

Volumn 332, Issue 1, 2005, Pages 206-214

  Gaur, Naseem Akhtar ^a   Manoharlal, Raman ^a   Saini, Preeti ^a   Prasad, Tulika ^a   Mukhopadhyay, Gauranga ^a   Hoefer, Milan ^b   Morschhäuser, Joachim ^c   Prasad, Rajendra ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Candida albicans; CDR1; Multidrug resistance; Promoter; Regulation

Indexed keywords

TETRAZOLE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CANDIDA ALBICANS; FUNGAL GENETICS; FUNGAL STRAIN; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY DNA SEQUENCE; REPORTER GENE; STRAIN DIFFERENCE; WILD TYPE;

ATP-BINDING CASSETTE TRANSPORTERS; AZOLES; CANDIDA ALBICANS; DRUG RESISTANCE; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENES, REGULATOR; MEMBRANE TRANSPORT PROTEINS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS;

CANDIDA ALBICANS;

EID: 19344367712     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.04.113     Document Type: Article

References (33)

1. R. Franz, S.L. Kelly, D.C. Lamb, D.E. Kelly, M. Ruhnke, and J. Morschhauser Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains Antimicrob. Agents Chemother. 42 1998 3065 3072
2. J.L. Lopez-Ribot, R.K. McAtee, L.N. Lee, W.R. Kirkpatrick, T.C. White, D. Sanglard, and T.F. Patterson Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal Candidiasis Antimicrob. Agents Chemother. 42 1998 2932 2937
3. R. Prasad, P.D. Worgifosse, A. Goffeau, and E. Balzi Molecular cloning and characterisation of a novel gene of C. albicans, CDR1, conferring multiple resistance to drugs and antifungals Curr. Genet. 27 1995 320 329
4. D. Sanglard, K. Kuchler, F. Ischer, J.-L. Pagani, M. Monod, and J. Bille Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters Antimicrob. Agents Chemother. 39 1995 2378 2386
5. T.C. White Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increased azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus Antimicrob. Agents Chemother. 41 1997 1482 1487
6. S. Krishnamurthy, V. Gupta, R. Prasad, S.L. Panwar, and R. Prasad Expression of CDR1, a multidrug resistance gene of Candida albicans: in vitro transcriptional activation by heat shock, drugs and human steroid hormones FEMS Microbiol. Lett. 160 1998 191 197
7. N. Puri, S. Krishnamurthy, S. Habib, S.E. Hasnain, S.K. Goswami, and R. Prasad CDR1, a multidrug resistance gene from Candida albicans, contains multiple regulatory domains in its promoter and the distal AP-1 element mediates its induction by miconazole FEMS Microbiol. Lett. 180 1999 213 219
8. N. Karnani, N.A. Gaur, S. Jha, N. Puri, S. Krishnamurthy, S.K. Goswami, G. Mukhopadhyay, and R. Prasad SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter Yeast 21 2004 219 239
9. M. de Micheli, J. Bille, C. Schueller, and D. Sanglard A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance Mol. Microbiol. 43 2002 1197 1214
10. D. De, and X.M. Raymond Constitutive activation of the PDR16 promoter in a Candida albicans azole-resistant clinical isolate overexpressing CDR1 and CDR2 Antimicrob. Agents Chemother. 48 2004 2700 2703
11. S. Wirsching, S. Michel, G. Kohler, and J. Morschhauser Activation of the multidrug resistance gene MDR1 in fluconazole resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor J. Bacteriol. 182 2000 400 404
12. M. Goto, S. Masuda, H. Saito, and K. Inui Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2 Biochem. Pharmacol. 66 2003 163 170
13. C.M. Laurencot, G.L. Scheffer, R.J. Scheper, and R.H. Shoemaker Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines Int. J. Cancer 72 1997 1021 1026
14. N.A. Gaur, N. Puri, N. Karnani, G. Mukhopadhyay, S.K. Goswami, and R. Prasad Identification of a negative regulatory element which regulates basal transcription of a multidrug resistance gene CDR1 of Candida albicans FEMS Yeast Res. 4 2004 389 399
15. R. Franz, M. Ruhnke, and J. Morschhauser Molecular aspects of fluconazole resistance development in Candida albicans Mycoses 42 1999 453 458
16. K. Biswas, and J. Morschhauser The Mep2p ammonium permiase controles nitrogen starvation-induced filamentous growth in Candida albicans Mol. Microbiol. 56 2005 649 669
17. M.A. Uhl, and A.D. Johnson Development of Streptococcus thermophilus lacZ as a reporter gene for Candida albicans Microbiology 147 2001 1189 1195
18. O. Reuss, A. Vik, R. Kolter, and J. Morschhauser The SAT1 flipper, an optimized tool for gene disruption in Candida albicans Gene 27 2004 119 127
19. J. Morschhauser, S. Michel, and J. Hacker Expression of a chromosomally integrated, single-copy GFP gene in Candida albicans, and its use as a reporter of gene regulation Mol. Gen. Genet. 257 1998 420
20. M. Karababa, A.T. Coste, B. Rognon, J. Bille, and D. Sanglard Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters Antimicrob. Agents Chemother. 48 2004 3064 3079
21. J. Morschhauser The genetic basis of fluconazole resistance development in Candida albicans Biochem. Biophys. Acta 1587 2002 240 248
22. A.T. Coste, M. Karababa, F. Ischer, J. Bille, and D. Sanglard TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2 Eukaryot. Cell 3 2004 1639 1652
23. S.E. Morgan, and W.T. Beck Role of an inverted CCAAT element in human topoisomerase IIalpha gene expression in ICRF-187-sensitive and -resistant CEM leukemic cells Mol. Pharmacol. 59 2001 203 211
24. K. Asakuno, K. Kohno, T. Uchiumi, T. Kubo, S. Sato, M. Isono, and M. Kuwano Involvement of DNA binding protein, MDR-NF-1/YB-1, in human MDR1 gene expression by actinomycin D Biochem. Biophys. Res. Commun. 199 1994 1428 1435
25. K. Hellauer, B. Akache, S. MacPherson, E. Sirard, and B. Turcotte Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter J. Biol. Chem. 277 2002 17671 17676
26. T.C. Hallstrom, and W.S. Moye-Rowley Divergent transcriptional control of multidrug resistance genes in Saccharomyces cerevisiae J. Biol. Chem. 273 1998 2098 2104
27. D.J. Katzmann, T.C. Hallstrom, Y. Mahe, and W.S. Moye-Rowley Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5 J. Biol. Chem. 271 1996 23049 23054
28. A. Kolaczkowska, and A. Goffeau Regulation of pleiotropic drug resistance in yeast Drug Resist. Updates 2 1999 403 414
29. A. Nawrocki, S.J. Fey, A. Goffeau, P. Roepstorff, and P.M. Larsen The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance Eur. J. Mass Spectrom. 7 2001 195 205
30. E. Carvajal, H.B. Van Den Hazel, A. Cybularz-Kolaczkowska, E. Balzi, and A. Goffeau Molecular and phenotypic characterisation of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes Mol. Gen. Genet. 256 1997 406 415
31. B. Akache, and B. Turcotte New regulators of drug sensitivity in the family of yeast zinc cluster proteins J. Biol. Chem. 277 2002 21254 21260
32. C.G. Chen, Y.L. Yang, H.I. Shih, C.L. Su, and H.J. Lo CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1 Antimicrob. Agents Chemother. 48 2004 4505 4512
33. A. Munir, A. Murad, C.D. Enfert, C. Gaillardin, H. Tournu, F. Tekaia, D. Talibi, D. Marechal, V. Marchais, J. Cottin, and A.J.P. Brown Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1 Mol. Microbiol. 42 2001 981 993