Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines

International Journal of Cancer

Volumn 72, Issue 6, 1997, Pages 1021-1026

  Laurençot, Carolyn M ^a   Scheffer, George L ^b   Scheper, Rik J ^b   Shoemaker, Robert H ^a  

^a Developmental Therapeutics Program   (United States)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; LUNG RESISTANCE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER RESISTANCE; COLON CARCINOMA; CONTROLLED STUDY; FIBROSARCOMA; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; LEUKEMIA; LUNG CARCINOMA; MESSENGER RNA SYNTHESIS; MULTIDRUG RESISTANCE; OVARY CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; RNA PROCESSING;

AMSACRINE; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL NUCLEUS; CISPLATIN; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; FEMALE; GLYCOPROTEINS; HUMANS; KIDNEY NEOPLASMS; LEUKEMIA; LUNG NEOPLASMS; MELPHALAN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; PHENOTYPE; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 0344858049     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970917)72:6<1021::AID-IJC17>3.0.CO;2-7     Document Type: Article

References (26)

1. BECH-HANSEN, N.T., TILL, J.E., and LING, V., Pleiotropic phenotype of colchicine-resistant CHO cells: cross-resistance and collateral sensitivity. J. Cell Physiolol., 88, 23-32 (1976).
2. BECK, W.T., DANKS, M.K., WOLVERTON, J.S., KIM, R. and CHEN, M., Drug resistance associated with altered DNA topoisomerase II. Adv. Enzyme Regul., 33, 113-127 (1993).
3. BIEDLER, J.L., Drug resistance: genotype versus phenotype. Cancer Res., 54, 666-678 (1994).
4. BIEDLER, J.L., and RIEHM, H., Cellular resistance to actinomycin D in Chinese hamster cells in vitro. Cancer Res., 30, 1174-1184 (1970).
5. CHIN, K.-V., PASTAN, I., and GOTTESMAN, M.M., Function and regulation of the human multidrug resistance gene. Adv. Cancer Res., 60, 157-180 (1993).
6. CHUGANI, D.C., ROME, L.H., and KEDERSHA, N.L., Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex. J. Cell Sci., 106, 23-29 (1993).
7. DANKS, M., YALOWICH, J., and BECK, W., Atypical multiple drug resistance in a human leukemic cell line selected for resistance in a human leukemic cell line selected for resistance to teniposide (VM-26). Cancer Res., 47, 1297-1301 (1987).
8. EIJDEMS, E.W.H.M., DE HAAS, M., COCO-MARTIN, J.M., OTTENHEIM, C.P.E., ZAMAN, G.J.R., DAUWERSE, H.G., BREUNING, M.H., TWENTYMAN, P.R., BORST, P. and BAAS, F., Mechanisms of MRP over-expression in four human lung-cancer cell lines and analysis of the MRP amplicon. Int. J. Cancer, 60, 676-684 (1995).
9. GOLDSTEIN, L.J., MDR1 gene expression in solid tumors. Europ. J. Cancer, 32A, 1039-1050 (1996).
10. IZQUIERDO, M.A., SCHEFFER, G.L., FLENS, M.J., SCHROEIJERS, A.B., VAN DER VALK, P., and SCHEPER, R.J., Major vault protein LRP-related multidrug resistance. Europ. J. Cancer, 32A, 979-984 (1996a).
11. IZQUIERDO, M.A., SHOEMAKER, R.H., FLENS, M.J., SCHEFFER, G.L., WU, L., PRATHER, T.R., and SCHEPER, R.J., Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines. Int. J. Cancer, 65, 230-237 (1996b).
12. IZQUIERDO, M.A. and 12 OTHERS. Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma. J. nat. Cancer Inst., 87, 1230-11237 (1995).
13. KEDERSHA, N.L., HEUSER, J.E., CHUGANI, D.C., and ROME, L.H., Vaults III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry. J. Cell Biol., 112, 225-235 (1991).
14. KEDERSHA, N.L., and ROME, L.H., Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA. J. Cell Biol., 103, 699-709 (1986).
15. LIST, A.F., SPIER, C.S., GROGAN, T.M., JOHNSON, C., ROE, D.J., GREER, J.P., WOLFF, S.N., BROXTERMAN, H.J., SCHEFFER, G.L., SCHEPER, R.J., and DALTON, W.S., Overexpression of the major vault transporter protein lung resistance protein predicts treatment outcome in acute myeloid leukemia. Blood, 87, 2464-2469 (1996).
16. LOE, D.W., DEELEY, R.G., and COLE, S.P.C., Biology of the multidrug resistance-associated protein. MRP. Europ. J. Cancer, 32A, 945-957 (1996).
17. MARIE, J.-P., ZHOU, D.-C., GURBUXANI, S., LEGRAND, O. and ZITTOUN, R., MDR1/P-glycoprotein in haematological neoplasms. Europ. J. Cancer, 32A, 1034-1038 (1996).
18. MARZLUFF, W.F. and HUANG, R.C.C., Transcription of RNA in isolated nuclei. In: B.D. Hames and S.J. Higgins (eds.), Transcription and translation: A practical approach, pp. 89-129, IRL Press, Oxford (1985).
19. NOOTER, K. and 14 OTHERS, Expression of the multidrug resistance-associated protein (MRP) gene in human cancers. Clin. Cancer Res., 1, 1301-1310 (1995).
20. ROME, L., KEDERSHA, N., and CHUGANI, D., Unlocking vaults: organelles in search of a function. Trends Cell Biol. 1, 47-50 (1991).
21. SCHEFFER, G.L., WIJNGAARD, P.L.J., FLENS, M.J., IZQUIERDO, M.A., SLOVAK, M.L., PINEDO, H.M., MEIJER, C.J.L.M., CLEVERS, H.C., and SCHEPER, R.J., The drug resistance-related protein LRP is the human major vault protein. Nature (Med.), 1, 578-582 (1995).
22. SLOVAK, M.L., HO, J.P., COLE, S.P., DEELEY, R.G., GREENBERGER, L., DE VRIES, E.G., BROXTERMAN, H.J., SCHEFFER, G.L., and SCHEPER, R.J., The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. Cancer Res., 55, 4214-9 (1995).
23. WU, L., SMYTHE, A.M., STINSON, S.F., MULLENDORE, L.A., MONKS, A., SCUDIERO, D.A., PAULL, K.D., KOUTSOUKOS, A.D., RUBINSTEIN, L.V., BOYD, M.R., and SHOEMAKER, R.H., Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. Cancer Res., 52, 3209-3034 (1992).
24. ZAMAN, G.J.R., FLENS, M.J., VAN LEUSDEN, M.R., DE HAAS, M., MULDER, H.S., LANKELMA, J., PINEDO, H.M., SCHEPER, R.J., BAAS, F., BROXTERMAN, H.J. and BORST, P., The human multidrug resistance-associated protein MRP is a plasma membrane drua-efflux pump. Proc. nat. Acad. Sci. (Wash.), 91, 8822-8826 (1994).
25. ZAMAN, G.J.R., VERSANTVOORT, C.H.M., SMIT, J.J.M., EIJDEMS, E.W.H.M., DEHAAS, M., SMITH, A.J., BROXTERMAN, H.J., MULDER, N.H., DE VRIES, E.G.E., BAAS, F., and BORST, P., Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug-resistant lung-cancer cell lines. Cancer Res., 53, 1747-1750 (1993).
26. ZINN, K., DIMAIO, D., and MANIATIS, T., Identification of two distinct regulatory regions adjacent to the human beta-interteron gene. Cell, 34, 865-879 (1983).