Subcellular distribution of Ras GTPase isoforms in normal human kidney

Nephrology Dialysis Transplantation

Volumn 20, Issue 5, 2005, Pages 886-891

  Kocher, Hemant M ^a,b   Senkus, Ron ^a   Al Nawab, Mashal ^a   Hendry, Bruce M ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Brush border; Mesangial cell; Mitochondria; Podocyte

Indexed keywords

GUANOSINE TRIPHOSPHATASE; ISOPROTEIN; RAS PROTEIN;

ADULT; AGED; ARTICLE; CANCER CELL; CASE REPORT; CELL FUNCTION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; FEMALE; GLOMERULUS BASEMENT MEMBRANE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGOLD LABELING; KIDNEY CELL; KIDNEY DISTAL TUBULE; KIDNEY PROXIMAL TUBULE; MALE; MESANGIUM CELL; MITOCHONDRION; PRIORITY JOURNAL; STAINING; TISSUE SECTION;

HUMANS; ISOENZYMES; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES; MICROSCOPY, ELECTRON; MITOCHONDRIA; RAS PROTEINS;

EID: 18944399797     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh744     Document Type: Article

References (20)

1. Downward J. Ras signalling and apoptosis. Curr Opin Genet Dev 1998; 8: 49
2. El-Nahas AM, Muchaneta-Kubara EC, Essawy M, Soylemezoglu O. Renal fibrosis: insights into pathogenesis and treatment. Int J Biochem Cell Biol 1997; 29: 55-62
3. Yan J, Roy S, Apolloni A, Lane A, Hancock JF. Ras isoforms vary in their ability to activate Raf-1 and PI3 kinase. J Biol Chem 1998, 273: 24052-24056
4. Yamamoto T, Harad N, Kano K et al. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. J Cell Biol 1997; 139: 785-795
5. Kocher HM, Codd J, Sharpe CC, Dockerell MEC, Al-Nawab M, Hendry BM. Expression of Ras GTPases in normal kidney and glomerulonephritis. Nephrol Dial Transplant 2003; 14: 848-854
6. Sharpe CC, Dockrell ME, Scott R et al. Evidence of a role for Ki-Ras in the stimulated proliferation of renal fibroblasts. J Am Soc Nephrol 1999; 10: 1186-1192
7. Sharpe CC, Dockrell MEC, Noor MI, Monia BP, Hendry BM. The role of Ras isoforms in the stimulated proliferation of human renal fibroblasts in primary culture. J Am Soc Nephrol 2000; 11: 1600-1606
8. Khwaja A, Conolly JO, Hendry BM. Prenylation inhibitors in renal disease. Lancet 2000; 9205: 741-744
9. Armbruster BL, Carlemalm E, Chiovetti R et al. Specimen preparation for electron microscopy using low temperature embedding resins. J Microsc 1982; 126: 77-85
10. Kocher HM, Senkus R, Moorhead J et al. Differential expression of Ras isoforms in normal and malignant human pancreas. Pancreatology (2005) Vol 5
11. Ruether GW, Der CJ. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Current Opin Cell Biol 2000; 12: 157-165
12. Voice JK, Klemke RL, Le A, Jackson JH. Four human Ras homologs differ in their abilities to activate Raf-1, induce transformation and stimulate cell motility. J Biol Chem 1999; 274: 17164-17170
13. Marte BM, Downward J. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci 1997; 22: 355-358
14. Ivanov IE, Philips MR. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell 1999; 98(1): 69-80
15. Apolloni A, Prior IA, Lindsay M, Parton RG, Hancock JF. H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol 2000; 20: 2475-2487
16. Rebollo A, Perez-Sala D, Martinez A. Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis. Oncogene 1999; 18: 4930-4939
17. Clarke HC, Kocher HM, Khwaja A, Kloog Y, Cook HT, Hendry BM. Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. J Am Soc Nephrol 2003; 14: 848-854
18. Smeets B, Dijkman HB, te Loeke NA et al. Podocyte changes upon induction of albuminuria in Thy-1.1 transgenic mice. Nephrol Dial Transplant 2003; 18: 2524-2533
19. Kretzler M. Regulation of adhesive interaction between podocytes and glomerular basement membrane. Microsc Res Tech 2002; 57: 247-253
20. Tanaka Y, Minami Y, Mine S et al. H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells. J Immunol 1999; 163: 6209-6216