Response in DNA ploidy of hepatocytes to tamoxifen and/or melatonin in vivo

Research Communications in Molecular Pathology and Pharmacology

Volumn 109, Issue 5-6, 2001, Pages 275-286

  Süzme, Rafi ^a   Gürdöl, Figen ^a   Deniz, Günnur ^b   Özden, Tülin ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Aneuploidy; Antiestrogenic activity; Cell proliferation; DNA ploidy; Flow cytometry; Hepatotoxicity; Melatonin; S phase; Tamoxifen

Indexed keywords

MELATONIN; TAMOXIFEN CITRATE;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DNA DETERMINATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; FLOW CYTOMETRY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL; NONHUMAN; PLOIDY; PRIORITY JOURNAL; RAT; RAT STRAIN;

ANEUPLOIDY; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; ANTIOXIDANTS; FEMALE; FLOW CYTOMETRY; HEPATITIS, TOXIC; MELATONIN; PLOIDIES; RATS; RATS, WISTAR; TAMOXIFEN;

EID: 18844468528     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Bartsch, C., Kvetnoy, I., Kvetnaia, T., Bartsch, H., Molotkov, A., Franz, H., Raikhlin, N. and Mecke, D. (1997). Nocturnal urinary 6-sulfatoxymelatonin and proliferating cell nuclear antigen-immunopositive tumor cells show strong positive correlations in patients with gastrointestinal and lung cancer. J. Pineal Res. 23: 90-96.
2. Blask, D.E. (1993). Melatonin in oncology. In: Melatonin, Biosynthesis, Physiological Effects, and Clinical Applications. Boca Raton, F.L. Edited by H.S. Yu and R.J. Reiter. CRC Press, Inc., 447-475.
3. 32P-postlabeling in three rat strains exposed to dietary tamoxifen: The relationship between cell proliferation and liver tumor formation. Carcinogenesis 16: 1299-1304.
4. Cos, S. and Sanchez-Barcelo, E.J. (1994). Differences between pulsatile or continuos exposure to melatonin on MCF-7 human breast cancer cell proliferation. Cancer Lett. 84: 105-109.
5. Cos, S. and Sanchez-Barcelo, E.J. (2000). Melatonin, experimental basis for a possible application in breast cancer prevention and treatment. Histol. Histopathol 15: 637-647.
6. Cos, S. and Sanchez-Barcelo, E.J. (1995). Melatonin inhibition of MCF-7 human breast cancer cells growth: influence of cell proliferation rate. Cancer Lett. 93: 207-212.
7. Dehal, S. and Kupfer, D.(1999). Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (Droloxifene) yielding tamoxifen catechol: Involvement of catechols in covalent binding to hepatic proteins. Drug Metab. Dis. 27: 681-688.
8. Dragan, Y.P., Fahey, S., Street, K., Vaughan, J., Jordan VC and Pitot HC: Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats. Breast Cancer Res. Treat. 31: 11-25, 1994.
9. Drazen, D.L., Klein, S.L., Yellon, S.M. and Nelson, R.J. (2000). In vitro melatonin treatment enhances splenocyte proliferation in prairie voles. J. Pineal Res. 28: 34-40.
10. Fernando, I.N., Titley, J.C., Powles, T.J., Dowsett, M., Trott, P.A., Ashley, S.E., Ford, H.T. and Ormerod, M.G. (1994). Measurement of S-phase fraction and ploidy in sequential fine-needle aspirates from primary human breast tumours treated with tamoxifen. Br. J. Cancer 70: 1211-1216.
11. Han, X. and Liehr, J.G. (1992). Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Res. 52: 1360-1363.
12. Hill, S.M. and Blask, D.E. (1988). Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res. 48: 6121-6126.
13. Hill, S.M., Spriggs, L.L., Simon, M.A., Muraoka, H. and Blask, D.E. (1992). The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system. Cancer Lett 64: 249-256.
14. Hirsimaki, P., Hirsimaki, Y., Nieminen, L. and Payne, B.J. (1993). Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens. Arch. Toxicol. 67: 49-54.
15. Jordan, V.C. (1997). Tamoxifen: the herald of a new era of preventive therapeutics. J. Natl. Cancer Inst. 89: 747-749.
16. Karasek, M., Liberski, P., Kunert-Radek, J. and Bartkowiak, J. (1992). Influence of melatonin on the proliferation of hepatoma cells in the Syrian hamster: in vivo and vitro study. J. Pineal Res. 13: 107-110.
17. King, C.M., Land, S.J., Jones, R.F., Debiec-Rychter, M., Lee, M.S. and Wang, C.Y. (1997). Role of acetyltransferases in the metabolism and carcinogenicity of aromatic amines, Mutat. Res. 376: 123-128.
18. Li, L., Wong, J.T., Pang, S.F. and Shiu, S.Y. (1999). Melatonin-induced stimulation of rat corpus epididiymal epithelial cell proliferation. Life Sci. 65: 1067-1076.
19. Maestroni, G.J.M. and Conti, A. (1996). Melatonin in human breast cancer tissue: Association with nuclear grade and estrogen receptor status. Lab. Invest. 75: 557-561.
20. Makris, A., Powles, T.J., Allred, D.C., Ashley, S., Ormerod, M.G., Titley, J.C. and Dowsett, M. (1998). Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response. Breast Cancer Res. Treat. 48: 11-20.
21. 32P-postlabelled DNA adducts in liver obtained from women treated with tamoxifen. Carcinogenesis 16: 1651-1654.
22. Maruyama, S., Hirayama, C., Abe, J., Tanaka, J. and Matsui, K. (1995). Chronic active hepatitis and liver cirrhosis in association with combined tamoxifen/tegafur adjuvant therapy. Dig. Dis. Sci. 40: 2602-2607.
23. Mediavilla, M.D., Cos, S. and Sanchez-Barcelo, E.J. (1999). Melatonin increases p53 and p21 WAF1 expression in MCF-7 human breast cancer cells in vitro. Life Sci. 65: 415-420.
24. Menendez-Pelaez, A. and Reiter, R.J. (1993). The distribution of melatonin in mammalian tissues: The relative importance of nuclear verses cytosolic localization. J. Pineal Res. 15: 59-69.
25. Molis, T.M., Spriggs, L. and Hill, S.M. (1994). Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Mol. Endocrinol. 8: 1681-1690.
26. Moretti, R.M., Marelli, M.M., Maggi, R., Dondi, D., Motta, M. and Limonta, P. (2000). Antiproliferative action of melatonin on human prostate cancer LNCaP cells. Oncol. Rep. 7: 347-351.
27. Nakade, O., Koyama, H., Ariji, H., Yajima, A. and Kaku, T. (1999). Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro. J. Pineal Res. 27: 106-110.
28. Nola, M., Juki & Cacute, S., Ili & Cacute-Forko, J., Babi & Cacute, D., Uzarevi & Cacute, B., Petrovecki, M., Suchanek, E., Skrablin, S., Dotli & Cacute, S. and Marusi & Cacute, M. (1999). Effects of tamoxifen on steroid hormone receptors and hormone concentration and the results of DNA analysis by flow cytometry in endometrial carcinoma. Gynecol. Oncol. 72: 331-336.
29. Oien, K.A., Moffat, D., Curry, G.W., Dickson, J., Habeshaw, T., Mills, P.R. and MacSween, R.N. (1999). Cirrhosis with steatohepatitis after adjuvant tamoxifen. Lancet 353: 36-37.
30. Papazisis, K.T., Kouretas, D., Geromichalos, G.D., Sivridis, E., Tsekreli, O.K., Dimitriadis, K.A. and Kortsaris, A.H. (1998). Effects of melatonin on proliferation of cancer cell lines. J. Pineal Res. 25: 211-218.
31. Phillips, D.H., Carmichael, P.L., Hewer, A., Cole, K.J., Hardcastle, I.R., Poon, G.K., Keogh, A., Strain, A.J. and Hewer, A. (1996). Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: Comparison between human, rat and mouse hepatocytes. Carcinogenesis 17: 89-94.
32. Popper, H., Selikoff, I.J., Maltoni, C., Squire, R.A. and Thomas, L.B. (1977). Comparison of neoplastic hepatic lesions in man and experimental animals. In: Origins of Human Cancer Book C. Human Risk Assesment. Edited by Hiatt NH, Watson JD, Winsten JA. Cold Spring Harbor Laboratory, New York, 1359-1382.
33. Ram, P.T., Yuan, L., Dai, J., Kiefer, T., Klotz, D.M., Spriggs, L.L. and Hill, S.M. (2000). Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin. J. Pineal Res. 28: 210-218.
34. Reiter, R.J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow-Walden, L., Chuang, J., Ortiz, G.G. and Acuna-Castroviejo, D. A. (1995). review of the evidence supporting melatonin's role as an antioxidant. J. Pineal Res. 18: 1-11.
35. Sargent, L.M., Dragan, Y.P., Sattler, C., Bahnub, N., Sattler, G., Martin, P., Cisneros, A., Mann, J., Thorgeirsson, S., Jordan, V.C. and Pitot, H.C. (1996). Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in Sprague-Dawley rats. Carcinogenesis 17: 1051-1056.
36. Slominski, A. and Pruski, D. (1993). Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells. Exp. Cell Res. 206: 189-194.
37. Williams, G.M., Iatropoulos, M.J., Djordjevic, M.V. and Kaltenberg, O.P. (1993). The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis 14: 315-317.
38. Yager, J.D., Liehr, J.G. (1996). Molecular mechanisms of estrogen carcinogenesis. Ann. Rev. Pharmacol Toxicol. 36: 203-232.