Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro

Journal of Pineal Research

Volumn 27, Issue 2, 1999, Pages 106-110

  Nakade, Osamu ^a   Koyama, Hiroki ^a   Ariji, Hirohiko ^a   Yajima, Akihiro ^a   Kaku, Tohru ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

Bone formation; Human osteoblastic cells; Melatonin; Osteogenic action; Proliferation; Type I collagen

Indexed keywords

COLLAGEN TYPE 1; GROWTH HORMONE; MELATONIN;

ARTICLE; BONE CELL; CELL PROLIFERATION; COLLAGEN SYNTHESIS; DOSE RESPONSE; GROWTH HORMONE RELEASE; GROWTH REGULATION; HORMONAL REGULATION; HUMAN; HUMAN CELL; OSSIFICATION;

ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; CELL DIVISION; CELL LINE; CELLS, CULTURED; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MELATONIN; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; PEPTIDE FRAGMENTS; PROCOLLAGEN; RATS;

EID: 0032873439     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.1999.tb00603.x     Document Type: Article

References (36)

1. ADELOYE, A., B. FELSON (1974) Incidence of normal pineal gland calcification in skull roentgenograms of black and white Americans. Am. J. Radiol. 122:503-507.
2. ARMSTRONG, S.M., J.R. REDMAN (1991) Melatonin: A chronobiotic with anti-aging properties? Med. Hypotheses 34:300-309.
3. BLASK, D.E., S.M. HILL, D.B. PELLETIER (1988) Oncostatic signaling by the pineal gland and melatonin in the control of breast cancer. In: The Pineal Gland and Cancer, D. Gupta, A Attanasio, R.J. Reiter, eds Brain Research Promotion, London, pp. 195-206.
4. CANE, V., D. FARNETI, G. MAROTTI, M. CRISCUOLO, G.P. TRENTINI, F. MAROTTI (1991) The effect of melatonin on bone growth in rats kept under constant light. Calcif. Tiss. Int.: A 47 (abstract).
5. CARR, D.D.B., S.M. REPPERT, B. BULLEN, G. SKRINAR, I. BETTINS, M. ARNOLD, M. ROSENBLATT, J.B. MARTIN, J.W. MCARTHUR (1981) Plasma melatonin increases during exercise in women. J. Clin. Endocrinol. Metab. 53:224-225.
6. FARLEY, J.R., U.M. JORCH (1983) Differential effects of phospholipids on skeletal alkaline phosphatase activity in extracts, in situ, and circulation. Arch. Biochem. Biophys. 221:477-488.
7. FARLEY, J.R., D.J. BAYLINK (1986) Skeletal alkaline phosphatase activity as a bone formation index in vitro. Metabolism 35:563-571.
8. GILAD, E., H. MATZKIN, N. ZISAPEL (1997) Interplay between sex steroids and melatonin in regulation of human benign prostate epithelial cell growth. J. Clin. Endocrinol. Metab. 82:2535-2541.
9. GLASCOTT, P.A. Jr. M. TSYGANSKAYA, E. GILFOR, M.A. ZERN, J.L. FARBER (1996) The antioxidant function of the physiological content of vitamin C. Mol. Pharmacol. 50:994-999.
10. HAKANSON, D.O., W.H. BERGSROM (1981) Phototherapy-induced hypocalcemia in newborn rats: Prevention by melatonin. Science 214:807-809.
11. HILL, S.M., D.E. BLASK (1988) Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res. 48:6121-6126.
12. KOJIMA, T., C. MOCHIZUKI, T. MITAKA, Y. MOCHIZUKI (1997) Effects of melatonin on proliferation, oxidative stress and Cx32 gap junction protein expression in primary cultures of adult rat hepatocytes. Cell Struct. Funct. 22:347-356.
13. KOYAMA, N., K. OHARA, H. YOKOTA, T. KUROME, M. KATAYAMA, F. HINO, I. KATO, T. AKAI (1991) A one step sandwich enzyme immunoassay for γ-carboxylated osteocalcin using monoclonal antibodies. J. Immunol. Methods 139:17-23.
14. LISSONI, P., S. BARNI, A. ARDIZZOIA, G. TANCINI, A. CONTI, G. MAESTRONI (1994) A randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms. Cancer 73:699-701.
15. MARSHALL, K.A., R.J. REITER, B. POEGGELER, O.I. ARUOMA, B. HALLIWELL (1996) Evaluation of the antioxidant activity of melatonin in vitro. Free Rad. Biol. Med. 21:307-315.
16. MOLIS, T.M., L.L. SPRIGGS, S.M. HILL (1994) Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Mol. Endocrinol. 8:1681-1690.
17. NAKADE, O., D.J. BAYLINK, K.-H.W. LAU (1995) Phenytoin at micromolar concentrations is an osteogenic agent for human-mandible-derived bone cells in vitro. J. Dent. Res. 74:331-337.
18. OWEN, T.A., M. ARONOW, V. SHALHOUB, L.M. BARONE, L. WILMING, M.S. TASSINARI, M.B. KENNEDY, S. POCKWINSE, J.B. LIAN, G.S. STEIN (1990) Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J. Cell Physiol. 143:420-430.
19. OXENKRUG, G.F., I.M. MEINTYRE, S. GERSHON (1984) Effects of pinealectomy and aging on the serum corticosterone circadian rhythm in rats. J. Pineal Res. 1:181-185.
20. PANZER, A., M. VILJOEN (1997) The validity of melatonin as an oncostatic agent. J. Pineal Res. 22:184-202.
21. POCKWINSE, S.M., L.G. WILMING, D.M. CONLON, G.S. STEIN, J.B. LIAN (1992) Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast. J. Cell Biochem. 49:310-323.
22. REITER, R.J. (1991) Pineal melatonin: Cell biology of its synthesis and of its physiological interaction. Endocr Rev. 12:151-180.
23. REITER, R.J., L. TANG, J.J. GARCIA, A. MUNOZ-HOYOS (1997) Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 60:2255-2271.
24. ROEHM, N.W., G.H. RODGERS, S.M. HATFIELD, A.L. GLASEBROOK (1991) An improved colormetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT. J. Immunol. Methods 142:257-265.
25. SACK, R.L., A.J. LEWY, D.L. ERB, W.M. VOLLMER, C.M. SINGER (1986) Human melatonin production decreases with age. J. Pineal Res. 3:379-388.
26. SANDYK, R. (1990) Possible role of pineal melatonin in the mechanisms of aging. Int. J. Neurosci. 52:85-92.
27. SANDYK, R., P.G. ANASTASIADIS, P.A. ANNINOS, N. TSAGAS (1992) Is postmenopausal osteoporosis related to pineal gland functions? Int. J. Neurosci. 62:215-225.
28. SILMAN, R.E., R.M. LEONE, R.J.L. HOOPER, M.A. PREECE (1979) Melatonin, the pineal gland and human puberty. Nature 282:301-303.
29. SMYTHE, G.A., L. LAZARUS (1974) Growth hormone responses to melatonin. Science 184:1373-1374.
30. SUZUKI, R., M. KOBAYASHI, T. TAKIGUCHI, A. YAMAGUCHI, M. NAGUMO, K. Hasegawa (1995) Bone morphogenetic protein-2 enhances the expression of the osteoblast phenotypes in human periodontal ligament fibroblasts and osteoblasts. J. Bone Miner. Res. 10 (Suppl 1):T216 (abstract).
31. TERMINE, J.D., P.G. ROBEY (1996) Bone matrix proteins and the mineralization process. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, M. Favus, ed. 3rd. Lippincott-Raven, Philadelphia, pp. 24-28.
32. VALCAVI, R., M. ZINI, G.J. MAESTRONI, A. CONTI, I. PORTIOLI (1993) Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone. Clin. Endocrinol. 39:193-199.
33. VAUGHAN, G.M., S.D. MCDONALD, R.M. JORDAN, J.P. ALLEN, G.L. BOHMFALK, M. ABOUSAMRA, J.L. STORY (1978) Melatonin concentration in human blood and cerebrospinal fluid: Relationship to stress. J. Clin. Endocrinol. Metab. 47:220-223.
34. WEGEDAL, J.E., D.J. BAYLINK (1984) Characterization of cells isolated and cultured from human bone. Proc. Soc. Exp. Biol. Med. 76:60-69.
35. WIECHELMAN, K., R. BRAUN, J. FITZPATRICK (1988) Investigation of bicinchoninin acid protein assay: Identification of the groups responsible for color formation. Anal. Biochem. 175:231-237.
36. YOCCA, F.D., E. FREIDMAN (1984) Effect of immobilization stress on rat pineal beta-adrenergic receptor-mediated function. J. Neurochem. 42:1417-1432.