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Volumn 17, Issue 5, 1996, Pages 1051-1056

Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats

Author keywords

[No Author keywords available]

Indexed keywords

1,1,2 TRIPHENYLETHYLENE DERIVATIVE; ANTIESTROGEN; DEMECOLCINE; IDOXIFENE; TAMOXIFEN CITRATE; TOREMIFENE;

EID: 15844385780     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.5.1051     Document Type: Article
Times cited : (38)

References (52)
  • 1
    • 0025338591 scopus 로고
    • Development of antiestrogens and their use in breast cancer: Eighth Cain Memorial Award Lecture
    • Lerner,L.J. and Jordan,V.C. (1990) Development of antiestrogens and their use in breast cancer: Eighth Cain Memorial Award Lecture. Cancer Res., 50, 4177-4189.
    • (1990) Cancer Res. , vol.50 , pp. 4177-4189
    • Lerner, L.J.1    Jordan, V.C.2
  • 2
    • 0027172047 scopus 로고
    • Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer
    • Jordan,V.C. (1993) Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer. Br. J. Pharmacol., 110, 507-517.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 507-517
    • Jordan, V.C.1
  • 3
    • 0021618186 scopus 로고
    • The pharmacology and clinical uses of tamoxifen
    • Furr,B. and Jordan,V. (1984) The pharmacology and clinical uses of tamoxifen. Pharmacol. Ther., 25, 127-205.
    • (1984) Pharmacol. Ther. , vol.25 , pp. 127-205
    • Furr, B.1    Jordan, V.2
  • 4
    • 0028129023 scopus 로고
    • The Royal Marsden Hospital pilot tamoxifen chemoprevention trial
    • Powles,T. et al. (1994) The Royal Marsden Hospital pilot tamoxifen chemoprevention trial. Breast Cancer Res. Treat., 31, 73-82.
    • (1994) Breast Cancer Res. Treat. , vol.31 , pp. 73-82
    • Powles, T.1
  • 5
    • 0024506261 scopus 로고
    • A randomized clinical trial evaluating tamoxifen in the treatment of patients with node negative breast cancer who have estrogen-receptor positive tumors
    • Fischer,B., Constantino,J., Redmond,C. and other members of NSABP (1989) A randomized clinical trial evaluating tamoxifen in the treatment of patients with node negative breast cancer who have estrogen-receptor positive tumors. New Engl. J. Med., 320, 479-484.
    • (1989) New Engl. J. Med. , vol.320 , pp. 479-484
    • Fischer, B.1    Constantino, J.2    Redmond, C.3
  • 6
    • 0026765044 scopus 로고
    • Breast cancer study initiated in Italy
    • Vanchieri.C. (1992) Breast cancer study initiated in Italy. J. Natl Cancer Inst., 84, 1555-1556.
    • (1992) J. Natl Cancer Inst. , vol.84 , pp. 1555-1556
    • Vanchieri, C.1
  • 7
    • 0027201501 scopus 로고
    • Two year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves,P., Goonetilleke,R., Nunn,G., Topham,J. and Orton,T. (1993) Two year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res., 53, 3919-3924.
    • (1993) Cancer Res. , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 8
    • 0027428568 scopus 로고
    • Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats
    • Hard,G., Iatropolis,M., Jordan,K., Radi,L., Kaltenberg.O., Imondi,A. and Williams,G. (1993) Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats. Cancer Res., 53, 4534-4541.
    • (1993) Cancer Res. , vol.53 , pp. 4534-4541
    • Hard, G.1    Iatropolis, M.2    Jordan, K.3    Radi, L.4    Kaltenberg, O.5    Imondi, A.6    Williams, G.7
  • 9
    • 0027397629 scopus 로고
    • Tamoxifen induces hepatocellular carcinoma in rat liver: A one year study with two antiestrogens
    • Hirsamaki,P., Hirsamaki,Y., Nieminen,L. and Payne,B. (1993) Tamoxifen induces hepatocellular carcinoma in rat liver: a one year study with two antiestrogens. Arch. Toxicol., 67, 49-54.
    • (1993) Arch. Toxicol. , vol.67 , pp. 49-54
    • Hirsamaki, P.1    Hirsamaki, Y.2    Nieminen, L.3    Payne, B.4
  • 10
    • 0022453672 scopus 로고
    • A new triphenylethylene compound. Fc-1157a. I. Hormonal effects
    • Kangas,L., Nieminen,A. and Blanco,G. (1986) A new triphenylethylene compound. Fc-1157a. I. Hormonal effects. Cancer Chemother. Pharmacol., 17, 103-108.
    • (1986) Cancer Chemother. Pharmacol. , vol.17 , pp. 103-108
    • Kangas, L.1    Nieminen, A.2    Blanco, G.3
  • 11
    • 0022468280 scopus 로고
    • A new triphenylethylene compound. Fc-1157a. II. Antitumor effects
    • Kallio,S., Kangas,L. and Blanco,G. (1986) A new triphenylethylene compound. Fc-1157a. II. Antitumor effects. Cancer Chemother. Pharmacol., 17, 109-117.
    • (1986) Cancer Chemother. Pharmacol. , vol.17 , pp. 109-117
    • Kallio, S.1    Kangas, L.2    Blanco, G.3
  • 13
    • 0025663351 scopus 로고
    • Preclinical studies with toremifene as an antitumor agent
    • Robinson,S., Parker,C, and Jordan,V.C. (1990) Preclinical studies with toremifene as an antitumor agent. Breast Cancer Res. Treat., 16 (Suppl.). 9-17.
    • (1990) Breast Cancer Res. Treat. , vol.16 , Issue.SUPPL. , pp. 9-17
    • Robinson, S.1    Parker, C.2    Jordan, V.C.3
  • 14
    • 0026345105 scopus 로고
    • Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen. new analogues of the antiestrogen tamoxifen for the treatment of breast cancer
    • Chander,S., McCague,R., Luqumani,Y., Newton,C., Doesett,M., Jarman,M. and Coombes,R. (1991) Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen. new analogues of the antiestrogen tamoxifen for the treatment of breast cancer. Cancer Res., 51, 5851-5858.
    • (1991) Cancer Res. , vol.51 , pp. 5851-5858
    • Chander, S.1    McCague, R.2    Luqumani, Y.3    Newton, C.4    Doesett, M.5    Jarman, M.6    Coombes, R.7
  • 15
    • 0028288381 scopus 로고
    • Influence of toremifene on the endocrine regulation in breast cancer patients
    • Szamel,l., Hindy,I., Vincze,B., Eckhardt,S., Kangas,L. and Hajba,A. (1994) Influence of toremifene on the endocrine regulation in breast cancer patients. Eur. J. Cancer, 30A, 154-158.
    • (1994) Eur. J. Cancer , vol.30 A , pp. 154-158
    • Szamel, L.1    Hindy, I.2    Vincze, B.3    Eckhardt, S.4    Kangas, L.5    Hajba, A.6
  • 17
    • 0028035492 scopus 로고
    • Genotoxicity of tamoxifen, toremifene epoxide. and toremifene in human lymphoblastoid cells containing human cytochrome P450s
    • Styles,J., Davies,A., Lim,C., de Matteis,F., Stanley,L., White,I., Yuan,Z. X. and Smith,L. (1994) Genotoxicity of tamoxifen, toremifene epoxide. and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 15, 5-9.
    • (1994) Carcinogenesis , vol.15 , pp. 5-9
    • Styles, J.1    Davies, A.2    Lim, C.3    De Matteis, F.4    Stanley, L.5    White, I.6    Yuan, Z.X.7    Smith, L.8
  • 18
    • 0028969780 scopus 로고
    • Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts
    • Davies,A., Martin,E., White,I., de Matteis,F., Edwards,R., Dorman,B., Heydon,R. and Smith,L. (1995) Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts. Carcinogenesis. 16, 539-545.
    • (1995) Carcinogenesis , vol.16 , pp. 539-545
    • Davies, A.1    Martin, E.2    White, I.3    De Matteis, F.4    Edwards, R.5    Dorman, B.6    Heydon, R.7    Smith, L.8
  • 19
    • 0027054733 scopus 로고
    • Genotoxic potential of tamoxifen and analogues in female Fischer F344/N rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells
    • White,I., de Matteis,F., Davies,A., Smith,L., Crofton-Sleigh,C., Venitt,S., Hewer,A. and Phillips,D. (1992) Genotoxic potential of tamoxifen and analogues in female Fischer F344/N rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. Carcinogenesis, 13, 2197-2203.
    • (1992) Carcinogenesis , vol.13 , pp. 2197-2203
    • White, I.1    De Matteis, F.2    Davies, A.3    Smith, L.4    Crofton-Sleigh, C.5    Venitt, S.6    Hewer, A.7    Phillips, D.8
  • 20
    • 0028233205 scopus 로고
    • Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female SD rats
    • Sargent,L., Dragan,Y., Bahnub,N., Wiley,J., Sattler,C., Schroeder,P., Sattler,G., Jordan,V.C. and Pitot,H.C. (1994) Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female SD rats. Cancer Res., 54. 3357-3360.
    • (1994) Cancer Res. , vol.54 , pp. 3357-3360
    • Sargent, L.1    Dragan, Y.2    Bahnub, N.3    Wiley, J.4    Sattler, C.5    Schroeder, P.6    Sattler, G.7    Jordan, V.C.8    Pitot, H.C.9
  • 21
    • 2642629512 scopus 로고
    • Comparison of the clastogenic effects induced in rats by tamoxifen and some of its analogues
    • A432
    • Styles,J., Davies,R. and Smith,L. (1995) Comparison of the clastogenic effects induced in rats by tamoxifen and some of its analogues. The Toxicologist, 15, 82(A432).
    • (1995) The Toxicologist , vol.15 , pp. 82
    • Styles, J.1    Davies, R.2    Smith, L.3
  • 22
    • 0020643393 scopus 로고
    • Chemical liver carcinogenesis: Monitoring of the process by flow cytometric DNA measurements
    • Digernes,V. (1983) Chemical liver carcinogenesis: monitoring of the process by flow cytometric DNA measurements. Environ. Health Perspect., 50, 195-200.
    • (1983) Environ. Health Perspect. , vol.50 , pp. 195-200
    • Digernes, V.1
  • 23
    • 0024240071 scopus 로고
    • A method for the comparative study of replicative DNA synthesis in GGT-positive and GGT-negative hepatocytes in primary culture isolated from carcinogen-treated rats
    • Xu,Y.H., Sattler,G. and Pitot,H. (1988) A method for the comparative study of replicative DNA synthesis in GGT-positive and GGT-negative hepatocytes in primary culture isolated from carcinogen-treated rats. In Vitro Cell Dev. Biol., 24. 995-1000.
    • (1988) In Vitro Cell Dev. Biol. , vol.24 , pp. 995-1000
    • Xu, Y.H.1    Sattler, G.2    Pitot, H.3
  • 24
    • 0024213490 scopus 로고
    • Electron microscopic and time lapse studies of mitosis in cultured rat hepatocytes
    • Sattler,C., Sawada,N., Sattler,G. and Pitot,H. (1988) Electron microscopic and time lapse studies of mitosis in cultured rat hepatocytes. Hepatology, 8, 1540-1549.
    • (1988) Hepatology , vol.8 , pp. 1540-1549
    • Sattler, C.1    Sawada, N.2    Sattler, G.3    Pitot, H.4
  • 25
    • 0028245751 scopus 로고
    • Direct determination of tamoxifen and its four major metabolites in plasma using coupled column high performance liquid chromatography
    • Fried,K. and Wainer,I. (1994) Direct determination of tamoxifen and its four major metabolites in plasma using coupled column high performance liquid chromatography. J. Chromatog. B, 655, 261-268.
    • (1994) J. Chromatog. B , vol.655 , pp. 261-268
    • Fried, K.1    Wainer, I.2
  • 26
    • 0026064491 scopus 로고
    • Metabolites, pharmacodynamics. and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
    • Robinson,S., Langan-Fahey,S., Johnson,D. and Jordan,V.C. (1991) Metabolites, pharmacodynamics. and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug. Metab. Dispos., 19. 36-43.
    • (1991) Drug. Metab. Dispos. , vol.19 , pp. 36-43
    • Robinson, S.1    Langan-Fahey, S.2    Johnson, D.3    Jordan, V.C.4
  • 27
    • 0028987866 scopus 로고
    • Tamoxifen: Toxicities and drug resistance during the treatment and prevention of breast cancer
    • Jordan,V.C. (1995) Tamoxifen: toxicities and drug resistance during the treatment and prevention of breast cancer. Annu. Rev. Pharmacol. Toxicol., 35. 195-211.
    • (1995) Annu. Rev. Pharmacol. Toxicol. , vol.35 , pp. 195-211
    • Jordan, V.C.1
  • 28
    • 0025292192 scopus 로고
    • Review of the pharmacological properties of toremifene
    • Kangas,L. (1990) Review of the pharmacological properties of toremifene. J. Steroid Biochem., 36, 191-195.
    • (1990) J. Steroid Biochem. , vol.36 , pp. 191-195
    • Kangas, L.1
  • 29
    • 0026425653 scopus 로고
    • Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment
    • Lien,E., Solheim,E. and Ueland,P. (1991) Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment. Cancer Res., 51, 4837-4844.
    • (1991) Cancer Res. , vol.51 , pp. 4837-4844
    • Lien, E.1    Solheim, E.2    Ueland, P.3
  • 31
    • 0025010197 scopus 로고
    • Metabolism of the 4-iodo derivative of tamoxifen by isolated rat hepatocytes: Demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites
    • McCague,R., Parr,I. and Haynes,B. (1990) Metabolism of the 4-iodo derivative of tamoxifen by isolated rat hepatocytes: demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites. Biochem. Pharmacol., 40, 2277-2283.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 2277-2283
    • McCague, R.1    Parr, I.2    Haynes, B.3
  • 32
    • 15844404582 scopus 로고
    • Oestrogens, progestins and combinations
    • International Agency for Research on Cancer, Lyon
    • Oestrogens, progestins and combinations (1987) IARC Monographs Suppl. 7 on the Evaluation of Carcinogenic Risks to Humans. International Agency for Research on Cancer, Lyon, pp. 272-288.
    • (1987) IARC Monographs Suppl. 7 on the Evaluation of Carcinogenic Risks to Humans , pp. 272-288
  • 33
    • 0024505761 scopus 로고
    • Points of estrogen antagonists and a calmodulin antagonist within MCF-7 cell cycle
    • Musgrove,E., Wakeling,A. and Sutherland,R. (1989) Points of estrogen antagonists and a calmodulin antagonist within MCF-7 cell cycle. Cancer Res., 49, 2398-2404.
    • (1989) Cancer Res. , vol.49 , pp. 2398-2404
    • Musgrove, E.1    Wakeling, A.2    Sutherland, R.3
  • 34
    • 0020606637 scopus 로고
    • Effects of tamoxifen on human breast cancer cell cycle kinetics: Accumulation of cells in early G1 phase
    • Osborne,C., Boldt,D., Clark,G. and Trent,J. (1983) Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase. Cancer Res., 43, 3583-3585.
    • (1983) Cancer Res. , vol.43 , pp. 3583-3585
    • Osborne, C.1    Boldt, D.2    Clark, G.3    Trent, J.4
  • 35
    • 0027171407 scopus 로고
    • Effects of tamoxifen and the derivative (TAT) on cell cycle of MCF-7 in vitro
    • Tominaga,T., Yoshida,Y., Matsumoto,A., Hayashi,K. and Kosaki,G. (1993) Effects of tamoxifen and the derivative (TAT) on cell cycle of MCF-7 in vitro. Anticancer Res., 13, 661-665.
    • (1993) Anticancer Res. , vol.13 , pp. 661-665
    • Tominaga, T.1    Yoshida, Y.2    Matsumoto, A.3    Hayashi, K.4    Kosaki, G.5
  • 38
    • 0026754030 scopus 로고
    • Antagonistic effect of triphenylethylenic antiestrogens on the association of estrogen receptor to calmodulin
    • Bouhoute,A. and Leclerq,G. (1992) Antagonistic effect of triphenylethylenic antiestrogens on the association of estrogen receptor to calmodulin. Biochem. Biophys. Res. Commun., 184, 1432-1440.
    • (1992) Biochem. Biophys. Res. Commun. , vol.184 , pp. 1432-1440
    • Bouhoute, A.1    Leclerq, G.2
  • 39
    • 0020062918 scopus 로고
    • Calmodulin and the cell cycle: Involvement in regulation of cell-cycle progression
    • Chafouleas,J., Bolton,W., Hidaka,H., Boyd.A. and Means,A. (1982) Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression. Cell. 28. 41-51.
    • (1982) Cell , vol.28 , pp. 41-51
    • Chafouleas, J.1    Bolton, W.2    Hidaka, H.3    Boyd, A.4    Means, A.5
  • 41
    • 0023992460 scopus 로고
    • Low concentrations of trifluoperazine arrest the cell cycle division cycle of Saccharomyces cerevisiae at two specific stages
    • Eilam,Y. and Chernichovsky,D. (1988) Low concentrations of trifluoperazine arrest the cell cycle division cycle of Saccharomyces cerevisiae at two specific stages. J. Gen. Microbiol., 134, 1063-1069.
    • (1988) J. Gen. Microbiol. , vol.134 , pp. 1063-1069
    • Eilam, Y.1    Chernichovsky, D.2
  • 42
    • 0023661342 scopus 로고
    • Calmodulin is involved in regulation of cell proliferation
    • Rasmussen,C. and Means,A. (1987) Calmodulin is involved in regulation of cell proliferation. EMBO J., 6. 3961-3968.
    • (1987) EMBO J. , vol.6 , pp. 3961-3968
    • Rasmussen, C.1    Means, A.2
  • 43
    • 0024440855 scopus 로고
    • Calmodulin is required for cell-cycle progression during G1 and mitosis
    • Rasmussen,C. and Means,A. (1989) Calmodulin is required for cell-cycle progression during G1 and mitosis. EMBO J., 8, 73-82.
    • (1989) EMBO J. , vol.8 , pp. 73-82
    • Rasmussen, C.1    Means, A.2
  • 45
    • 0024286809 scopus 로고
    • Rearrangement of nuclear calmodulin during proliferative liver cell activation
    • Serratosa,J., Pujol,M., Bachs,O. and Carafoli,E. (1988) Rearrangement of nuclear calmodulin during proliferative liver cell activation. Biochem. Biophys. Res. Commun., 150, 1162-1169.
    • (1988) Biochem. Biophys. Res. Commun. , vol.150 , pp. 1162-1169
    • Serratosa, J.1    Pujol, M.2    Bachs, O.3    Carafoli, E.4
  • 46
    • 0022587684 scopus 로고
    • Induction of myeloid differentiation of HL-60 with naphthalene sulfonamide calmodulin antagonists
    • Veigl,M., Sedwick,W., Niedel,J. and Brabch,M. (1986) Induction of myeloid differentiation of HL-60 with naphthalene sulfonamide calmodulin antagonists. Cancer Res., 46, 2300-2305.
    • (1986) Cancer Res. , vol.46 , pp. 2300-2305
    • Veigl, M.1    Sedwick, W.2    Niedel, J.3    Brabch, M.4
  • 47
    • 0026694266 scopus 로고
    • A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin
    • Edwards,K., Laughton,C. and Neidle,S. (1992) A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin. J. Med. Chem., 35. 2753-2761.
    • (1992) J. Med. Chem. , vol.35 , pp. 2753-2761
    • Edwards, K.1    Laughton, C.2    Neidle, S.3
  • 48
    • 0025277529 scopus 로고
    • Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen: Correlations with cytotoxicity
    • Rowlands,M., Parr,I., McCague,R., Jarman,M. and Goddard,P. (1990) Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen: correlations with cytotoxicity. Biochem. Pharmacol., 40, 283-289.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 283-289
    • Rowlands, M.1    Parr, I.2    McCague, R.3    Jarman, M.4    Goddard, P.5
  • 49
    • 0011876884 scopus 로고
    • Characterization of tamoxifen induced DNA adducts formed in rat liver
    • 811A
    • Martin,E., Turtebaub,K., Heydon,R., Davies,A., White,I. and Smith,L. (1995) Characterization of tamoxifen induced DNA adducts formed in rat liver. Toxicologist. 15, 152(811A).
    • (1995) Toxicologist , vol.15 , pp. 152
    • Martin, E.1    Turtebaub, K.2    Heydon, R.3    Davies, A.4    White, I.5    Smith, L.6
  • 51
    • 0027436314 scopus 로고
    • Chromosomes lacking kinetochore proteins: Their meta-anaphase location susgests potential malsegregation
    • Yoo,H. and Vig,K. (1993) Chromosomes lacking kinetochore proteins: their meta-anaphase location susgests potential malsegregation. Mutagenesis. 8, 553-560.
    • (1993) Mutagenesis , vol.8 , pp. 553-560
    • Yoo, H.1    Vig, K.2


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