Molecular and genetic insights into ligand binding and signal transduction at the inhibitory glycine receptor

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 61, Issue , 1996, Pages 333-342

  Schofield, P R ^a   Lynch, J W ^a   Rajendra, S ^b   Pierce, K D ^a   Handford, C A ^a   Barry, P H ^b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GABAERGIC RECEPTOR AFFECTING AGENT; GLYCINE RECEPTOR;

BINDING SITE; CELL ENERGY; CONFERENCE PAPER; ELECTROPHYSIOLOGY; ION PERMEABILITY; NEUROTRANSMISSION; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; ARTICLE; LIGAND BINDING;

EID: 0030441739     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1996.061.01.037     Document Type: Conference Paper

References (75)

1. Akagi, H., K. Hirai, and F. Hishinuma. 1991. Cloning of a glycine receptor subtype expressed in rat brain and spinal cord during a specific period of neuronal development. FEBS Lett. 281: 160.
2. A receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentabarbital. Nature 366: 565.
3. Aylwin, M.L. and M.M. White. 1994. Gating properties of mutant acetylcholine receptors. Mol. Pharmacol. 46: 1149.
4. Becker, C.-M., V. Schmieden, P. Tarroni, U. Strasser, and H. Betz. 1992. Isoform-selective deficit of glycine receptors in the mouse mutant spastic. Neuron 8: 283.
5. Bormann, J., N. Rundstrom, H. Betz, and D. Langosch. 1993. Residues within the M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers. EMBO J. 12: 3729.
6. Buckwalter, M.S., S.A. Cook, M.T. Davisson, W.F. White, and S.A. Camper. 1994. A frameshift mutation in the mouse alpha 1 glycine receptor gene (Glra 1) results in progressive neurological symptoms and juvenile death. Hum. Mol. Genet. 3: 2025.
7. Campos-Caro, A., S. Sala, J.J. Ballesta, F. Vicente-Agullo, M. Criado, and F. Sala. 1996. A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors. Proc. Natl. Acad. Sci. 93: 6118.
8. Chai, C.K. 1961. Hereditary spasticity in mice. J. Hered. 52: 241.
9. 3H]acetylcholine mustard identifies residues in the cation-binding subsite. J. Biol. Chem. 266: 23354.
10. Cook, S.A. 1993. Oscillator (ot). Mouse Genome 91: 117.
11. Cully, D.F., D.K. Vassilatis, K.K. Liu, P.S. Paress, L.T.T. Van der Ploeg, J.M. Shaeffer, and J.P. Arena. 1994. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 371: 707.
12. Dennis, M., J. Giraudat, F. Kotzyba-Hibert, M. Goeldner, C. Hirth, J.Y. Chang, C. Lazure, M. Chretien, and J.P. Changeux. 1988. Amino acids of the Torpedo marmorata acetylcholine receptor α subunit labelled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry 27: 2346.
13. Devillers-Thiery, A., J.L. Galzi, J.L. Eisele, S. Bertrand, D. Bertrand, and J.P. Changeux. 1993. Functional architecture of the nicotinic acetylcholine receptor A prototype of ligand-gated ion channels. J. Membr. Biol. 136: 97.
14. Elmslie, F.V., S.M. Hatchings, V. Spencer, A. Curtis, T. Covanis, R.M. Gardiner, and M. Rees. 1996. Analysis of GLRA1 in hereditary and sporadic hyperekplexia: A novel mutation in a family cosegragating for hyperekplexia and spastic paraparesis. J. Med. Genet. 33: 435.
15. Galzi, J.L., S.J. Edelstein, and J.-P. Changeux. 1996. The multiple phenotypes of allosteric receptor mutants. Proc. Natl. Acad. Sci. 93: 1853.
16. Galzi, J.-L., D. Bertrand, A. Devillers-Thiery, F. Revah, S. Bertrand, and J.-P. Changeux. 1991. Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site-directed mutagenesis. FEBS Lett. 294: 198.
17. Galzi, J.-L., F. Revah, D. Black, M. Goeldner, C. Hirth, and J.-P. Changeux. 1990. Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites. J. Biol. Chem. 265: 10430.
18. Graham, D., F. Pfeiffer, and H. Betz. 1982. Purification by affinity chromatography of the glycine receptor of rat spinal cord. J. Biol. Chem. 257: 9389.
19. Grenningloh, G., I. Pribilla, P. Prior, G. Malthaup, K. Beyreuther, O. Taleb, and H. Betz. 1990a. Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor. Neuron 4: 963.
20. Grenningloh, G., A. Rienitz, B. Schmitt, C. Methfessel, M. Zensen, K. Beyreuther, E. E. Gundelfinger, and H. Betz. 1987. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 328: 215.
21. Grenningloh, G., V. Schmeiden, P.R. Schofield, P.H. Seeburg, T. Siddique, T.K. Mohandas, C.-M. Becker, and H. Betz. 1990b. Alpha subunit variants of the human glycine receptor. Primary structures, functional expression and chromosomal localisation of the corresponding genes. EMBO J. 9: 771.
22. Gundlach, A.L., P.S. Dodd, C.S. Grabara, W.E. Watson, G.A.R. Johnston, P.A. Harper, J.A. Dennis, and P.J. Healy. 1988. Deficit of spinal cord glycine/strychnine receptors in inherited myoclonus of Poll Hereford calves. Science 241: 1807.
23. Handford, C.A., J.W. Lynch, E. Baker, G.C. Webb, J.C. Ford, G.R. Sutherland, and P.R. Schofield. 1996. The human glycine receptor β subunit: Primary structure, functional characterization and chromosomal localization of the human and murine genes. Mol. Brain Res. 35: 211.
24. Hoch, W., H. Betz, and C.-M. Becker. 1989. Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor. Neuron 3: 339.
25. Kao, P., A. Dwork, R. Kaldany, M. Silver, J. Wideman, S. Stein, and A. Karlin. 1984. Identification of the α-subunit half-cystine specifically labelled by an affinity reagent for the acetylcholine receptor binding site. J. Biol. Chem. 259: 11662.
26. Kelly, J.S. and K. Krnjevic. 1969. The action of glycine on cortical neurones. Exp. Brain Res. 9: 155.
27. Kingsmore, S.F., B. Giros, D. Suh, M. Bieniarz, M.G. Caron, and M.F. Seldin. 1994. Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion. Nat. Genet. 7: 136.
28. Kirsch, J. and H. Betz. 1995. The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J. Neurosci. 15: 4148.
29. Kirsch, J., D. Langosch, P. Prior, U.Z. Littauer, B. Schmitt, and H. Betz. 1991. The 93-kDa glycine receptor-associated protein binds to tubulin. J. Biol. Chem. 266: 22242.
30. Kuhse, J., V. Schmieden, and H. Betz. 1990a. A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit. Neuron 5: 867.
31. _. 1990b. Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor. J. Biol. Chem. 265: 22317.
32. Kuhse, J., B. Laube, D. Magalei, and H. Betz. 1993. Assembly of the inhibitory glycine receptor: Identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 11: 1049.
33. Kuhse, J., A. Kuryatov, Y. Maulet, M.L. Malosio, V. Schmeiden, and H. Betz. 1991. Alternative splicing generates two isoforms of the alpha 2 subunit of the inhibitory glycine receptor. FEBS Lett. 283: 73.
34. Kusana, T., J.B. Wang, C.E. Spivak, and G.R. Uhl. 1994. Mutagenesis of the GABA rhol receptor alters agonist affinity and channel gating. NeuroReport 5: 1209.
35. Lane, P.W., A.L. Ganser, A.-L. Kerner, and W.F. White. 1987. Spasmodic, a mutation on chromosome 11 in the mouse. J. Hered. 78: 353.
36. Langosch, D., L. Thomas, and H. Betz. 1988. Conserved quaternary structure of ligand-gated ion channels: The postsynaptic glycine receptor is a pentamer. Proc. Natl. Acad. Sci. 85: 7394.
37. Langosch, D., B. Laube, N. Rundstrom, V. Schmieden, J. Bormann, and H. Betz. 1994. Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia. EMBO J. 13: 4223.
38. Laube, B., D. Langosch, H. Betz, and V. Schmieden. 1995b. Hyperekplexia mutations of the glycine receptor unmask the inhibitory subsite for β-amino-acids. Neuroreport 6: 897.
39. Lynch, J.W., S. Rajendra, P.H. Barry, and P.R. Schofield. 1995. Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator. J. Biol. Chem. 270: 13799.
40. Malosio, M.L., G. Grenningloh, J. Kuhse, V. Schmeiden, B. Schmitt, P. Prior, and H. Betz. 1991. Alternative splicing generates two variants of the α1 subunit of the inhibitory glycine receptor. J. Biol. Chem. 266: 2048.
41. Maricq, A.V., A.S. Peterson, A.J. Brake, R.M. Myers, and D. Julius. 1991. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion-channel. Science 254: 432.
42. Marvison, J.C.G., M.G. Clavo, J. Vazques, and F. Mayor, Jr. 1986. The glycine receptor Pharmacological studies and mathematical modelling of the allosteric interaction between the glycine- and strychnine-binding sites. Mol. Pharmacol. 30: 590.
43. Matzenbach, B., Y. Maulet, L. Sefton, B. Courtier, P. Avner, J.-L. Guenet, and H. Betz. 1994. Structural analysis of mouse glycine receptor α subunit genes. Identification and chromosomal localization of a novel variant. J. Biol. Chem. 269: 2607.
44. Mihic, SJ., P.J. Whiting, R.L. Klein, K.A. Wafford, and R.A. Harris. 1994. A single amino acid of the human γ-aminobutyric acid type A receptor γ2 subunit determines benzodiazepine efficacy. J. Biol. Chem. 52: 32768.
45. Mulhardt, C., M. Fischer, P. Gass, D. Simon-Chazottes, J.-L. Guenet, J. Kuhse, H. Betz, and C.-M. Becker. 1994. The spastic mouse: Aberrant splicing of glycine receptor beta subunit mRNA caused by intronic insertion of L1 element. Neuron 13: 1003.
46. Murray, N., Z. Ying-Cong, G. Mandel, P. Brehm, R. Bolinger, Q. Reuter, and R. Kullberg. 1995. A single site on the ε subunit is responsible for the change in Ach receptor channel conductance during skeletal muscle development. Neuron 14: 865.
47. Noda, M., H. Takahashi, T. Tanabe, M. Toyosato, Y. Furutani, T. Hirose, H. Takashima, S. Inayama, T. Miyata, and S. Numa. 1982. Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 299: 793.
48. O'Leary, M.E. and M.M. White. 1992. Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor. J. Biol. Chem. 267: 8360.
49. Rajendra, S. and P.R. Schofield, 1995. Molecular mechanisms of startle syndromes. Trends Neurosci. 18: 80.
50. Rajendra, S., J.W. Lynch, K.D. Pierce, C.R. French, P.H. Barry, and P.R. Schofield. 1994. Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor. J. Biol. Chem. 269: 18739.
51. _ 1995a. Mutation of a single amino acid in the human glycine receptor transforms β-alanine and taurine from agonists into competitive antagonists. Neuron 14: 169.
52. Rajendra, S., R.J. Vandenberg, K.D. Pierce, A.M. Cunningham, P.W. French, P.H. Barry, and P.R. Schofield. 1995b. The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element. EMBO J. 14: 2987.
53. Rees, M.I., M. Andrew, S. Jawad, and MJ. Owen. 1994. Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the α1 subunit of the inhibitory glycine receptor. Hum. Mol. Genet. 3: 2175.
54. Ruiz-Gomez, A., E. Morato, M. Garcia-Calvo, F. Valdivieso, and F. Mayor, Jr. 1990. Location of the strychnine binding site on the 48-kilodalton subunit of the glycine receptor. Biochemistry 29: 7033.
55. Rundström, N., V. Schmieden, H. Setz, J. Bormann, and D. Langosch. 1994. Cyanotriphenylborate: Subtype-specific blocker of glycine receptor chloride channels. Proc. Natl. Acad. Sci. 91: 8950.
56. Ryan, S.G., S.L. Sherman, J.C. Terry, R.S. Sparkes, M.C. Torres, and R.W. Mackey. 1992. Startle disease, or hyperekplexia: Response to clonazepam and assignment of the gene (STHE) to chromosome 5q by linkage analysis. Ann. Neurol. 31: 663.
57. Ryan, S.G., M.S. Buckwalter, J.W. Lynch, C.A. Handford, L. Segura, R. Shiang, J.J. Wasmuth, S.A. Camper, P.R. Schofield, and P. O'Connell. 1994. A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse. Nat. Genet. 7: 131.
58. Saul, B., V. Schmieden, C. Kling, C. Mulhardt, P. Gass, J. Kuhse, and C.-M. Becker. 1994. Point mutation of glycine receptor α1 subunit in spasmodic mouse affects agonist responses. FEBS Lett. 350: 71.
59. Schmieden, V., J. Kuhse, and H. Betz. 1992. Agonist pharmacology of neonatal and adult glycine receptor α subunits: Identification of amino acid residues involved in taurine activation. EMBO J. 11: 2025.
60. _. 1993. Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA. Science 262: 256.
61. Schmieden, V., G. Grenningloh, P.R. Schofield, and H. Betz. 1989. Functional expression in Xenopus oocytes of the strychnine binding 48kD subunit of the inhibitory glycine receptor. EMBO J. 8: 695.
62. A receptor shows a ligand-gated receptor super-family. Nature 328: 221.
63. Shiang, R., S.G. Ryan, Y.-Z. Zhu, A.F. Hahn, P. O'Connell, and J.J. Wasmuth. 1993. Mutations in the α1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Nat. Genet. 5: 351.
64. Shiang, R., S.G. Ryan, Y.Z. Zhu, T.J. Fielder, R.J. Allen, A. Fryer, S. Yamashita, P. O'Connell, and J.J. Wasmuth. 1995. Mutational analysis of familial and sporadic hyperekplexia. Ann. Neurol. 38: 85.
65. Sontheimer, H., C.-M. Becker, D.B. Pritchett, P.R. Schofield, G. Grenningloh, H. Kettenmann, H. Betz, and P.H. Seeburg. 1989. Functional chloride channels by mammalian cell expression of rat glycine receptor subunit. Neuron 2: 1491.
66. Suhren, O., G.W. Bruyn, and J.A. Tuynman. 1966. Hyperekplexia: A hereditary startle syndrome. J. Neurol. Sci. 3: 577.
67. Takahashi, T., A. Momiyama, K. Hirai, F. Hishinuma, and H. Akagi. 1992. Functional correlation of foetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels. Neuron 9: 1155.
68. Tokutomi, N., M. Kaneda, and N. Akaike. 1989. What confers specificity on glycine for its receptor site? Br. J. Pharmacol. 97: 353.
69. Unwin, N. 1993. Nicotinic acetylcholine receptor at 9Å resolution. J. Mol. Biol. 229: 1101.
70. _. 1995. Acetylcholine receptor channel imaged in the open state. Nature 373: 37.
71. Vandenberg, R.J., C.A. Handford, and P.R. Schofield. 1992a. Distinct agonist- and antagonist-binding sites on the glycine receptor. Neuron 9: 491.
72. Vandenberg, R.J., C.R. French, P.H. Barry, J. Shine, and P.R. Schofield. 1992b. Antagonism of ligand-gated ion channel receptors: Two domains of the glycine receptor α subunit form the strychnine binding site. Proc. Natl. Acad. Sci. 89: 1765.
73. A receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267: 1426.
74. White, W.F. and A.H. Heller. 1982. Glycine receptor alteration in the mutant mouse spastic. Nature 298: 655.
75. 3H-strychnine as the ligand. J. Neurosci. 10: 795.