Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

Neuron

Volumn 15, Issue 6, 1995, Pages 1231-1244

  Karlin, Arthur ^a   Akabas, Myles H ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACETYLCHOLINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; CYSTEINE; NICOTINIC RECEPTOR;

AMINO ACID SUBSTITUTION; CHANNEL GATING; ION CONDUCTANCE; MUTATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REVIEW; SYNAPTIC TRANSMISSION;

ACETYLCHOLINE; ANIMALS; BINDING SITES; HUMANS; ION CHANNEL GATING; ION CHANNELS; MUTATION; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029593370     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/0896-6273(95)90004-7     Document Type: Review

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14. Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal α7 nicotinic receptor
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18. Residues within transmembrane segment M2 determine chloride conductance of glucine treceptor homo- and hetero-oligomers
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20. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
21. An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor
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26. 3H]acetylcholine mustard identifies residues in the cation-binding subsite
27. Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations
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29. Identification of a new component of the agonist binding site of the nicotinic α7 homooligomeric receptor
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32. Structure of the nicotinic acetylcholine-binding site: Identification of acidic residues in the δ subunit with 0.9 nm of the α subunit-binding site disulfide
33. Negatively charged amino acid residues in the nicotinic receptor δ subunit that contribute to the binding of acetylcholine
34. Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica
35. Effects of agonists and antagonists on the reactivity of the binding site disulfide in acetylcholine receptor from Torpedo californica
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39. Complete mRNA coding sequence of the acetylcholine binding α subunit of Torpedo marmorata acetylcholine receptor a model for the transmembrane organization of the polypeptide chain
40. The sideness the COOH terminus of the acetylcholine receptor δ subunit
41. 3H]-quinacrine azide in the active state of the nicotinic acetylcholine receptor
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43. Monoclonal antibodies specific for each of the two toxin-binding sites of Torpedo acetylcholine receptor
44. The permeability of the endplate channel to organic rations in frog muscle
45. Chimaeric nicotinic serotonergic receptor combines distinct ligand binding and channel specificities
46. The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
47. Identification of a novel amino acid α-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites
48. Functional significance of aromatic amino acids from three peptide loops of the α-7 neuronal nicotinic receptor site investigated by site directed mutagenesis
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50. Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic
51. 3H]chlorpromazine
52. 3H]chlorpromazine labels homologous residues in the β and δ chains
53. 3H]chlorpromazine labels segment M2 but not segment M1 of the nicotinic acetylcholine receptor α-subunit
54. Mapping and modification of an antibody hapten binding site: a site-directed mutagenesis study of McPC603
55. The transmembrane domains of the nicotinic acetylocholine receptor contain α-helical and β structures
56. Molecular mechanisms of cyclic-nucleotide-gated channel activation
57. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
58. The α-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not
59. Rapid kinetics of agonist-binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata
60. Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic techniques
61. N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1
62. Selectivity of cations and nonelectrolytes for acetylcholine-activated channels in cultured muscle cells
63. The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits
64. Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
65. A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor
66. Spontaneous openings of the acetylcholine receptor channel
67. Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor
68. Identification of the a subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site
69. Acetylcholine receptor binding site contains a disulfide crosslink between adjacent half-cystinyl residues
70. Chemical modification of the active site of the acetylcholine receptor
71. Explorations of the nicotinic acetylcholine receptor
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74. Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism
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76. Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations
77. Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
78. Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer
79. Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function
80. Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor
81. Role of a key cysteine residue in the gating of the acetylcholine receptor
82. A/bezodiazepine receptor complex
83. The handedness of the subunit arrangement of the nicotinic acetylcholine receptor from Torpedo californica
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85. Transmembrane topography of the nicotinic acetylcholine receptor δ subunit
86. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons
87. A receptor subtypes immunopurified from rat brain with α subunit-specific antibodies have unique pharmacological properties
88. 3H]nicotine as an agonist photoaffinity label
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91. A receptors by cAMP-dependent protein phosphorylation
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93. A receptor determined by electron microscopic image analysis
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95. 3H]acetylcholine by Torpedo post-synaptic membranes: stoichiometry and ligand interactions
96. Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization
97. Structural homology of Torpedo californica acetylcholine receptor subunits
98. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
99. Congenital myasthenic syndrome caused by prolonged receptor channel openings due to a mutation in the M2 domain of the ε subunit
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104. A receptors of adult rat cerebellum demonstrates two a subunits per receptor oligomer
105. 3H]chlorpromazine labels three amino acids of the acetylcholine receptor γ subunit: implications for the α-helical organization of regions MII and for the structure of the ion channel
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107. Transmembrane topology of the glutamate receptor subunit GluR6
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110. Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA
111. A receptor shows a ligand-gated receptor super-family
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114. γ- and δ-subunits regulate the affinity and the cooperativity of ligand binding to the acetycholine receptor
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116. A receptor a subunit
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119. Nicotinic acetylcholine receptor superfamily of ligand-gated channels
120. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
121. Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain
122. Effects of substitution of putative transmembrane segments on nicotinic acetylcholine receptor function
123. Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor
124. The nicotinic acetylcholine receptor at 9 Å resolution
125. Acetylcholine receptor channel imaged in the open state
126. 2x receptor for extracellular ATP
127. Location of a threonine residue in the α-subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel
128. Asymmetry of the rat acetylcholine receptor subunits in the narrow region of the pore
129. Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist
130. Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation
131. Amino acids lining the channel of the γ-aminobutyric acid type A receptor identified by cysteine substitution
132. A receptor channel-lining residues probed in cysteine mutants
133. Single amino acid substitution affects desensitization of the 5-hydroxy-tryptamine type 3 receptor expressed in Xenopus oocytes
134. Determination of the sites of cAMP-dependent phosphorylation on the nicotinic acetylcholine receptor