Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-α and IL-1β

Clinical Immunology

Volumn 115, Issue 2, 2005, Pages 162-172

  Subramanian, Sandhya ^a   Tovey, Micah ^a   Afentoulis, Michael ^a   Krogstad, Aric ^d   Vandenbark, Arthur A ^a,b,c   Offner, Halina ^a,b,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

^e PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Collagen induced arthritis; Cytokines; Ethinyl estradiol; Oral therapy; Regulation of T cells and antibodies

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; COLLAGEN TYPE 2; CYTOKINE; ETHINYLESTRADIOL; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; LOW DRUG DOSE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 18844411612     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2005.01.006     Document Type: Article

References (41)

1. M. Feldmann, F.M. Brennan, and R.N. Maini Role of cytokines in rheumatoid arthritis Annu. Rev. Immunol. 14 1966 397 440
2. B. Bolon, G. Campagnuolo, L. Zhu, D. Duryea, D. Zack, and U. Feige Interleukin-1beta and tumor necrosis factor-alpha produce distinct, time-dependent patterns of acute arthritis in the rat knee Vet. Pathol. 41 2004 235 243
3. q and CRB1*0401 (DW4) transgenic mice from arthritis J. Immunol. 171 2003 4431 4438
4. L.K. Myers, S. Yoshihiko, B. Tang, X. He, E.F. Rosloniec, J.M. Stuart, and A.H. Kang Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice Arthritis Rheum. 46 2002 3369 3377
5. C.C. Whitacre, S.C. Reingold, and P.A. O'Looney MSaA task force on gender: a gender gap in autoimmunity Science 283 1999 1277 1278
6. R.L. Wilder Hormones, pregnancy and autoimmune diseases Ann. N. Y. Acad. Sci. 840 1998 45 50
7. J.P. Buyon The effects of pregnancy on autoimmune diseases J. Leukocyte Biol. 63 1998 281 287
8. R. Mattsson, A. Mattsson, R. Holmdahl, A. Whyte, and G.A. Rook Maintained pregnancy levels of oestrogen afford complete protection from post-partumexacerbation of collagen-induced arthritis Clin. Exp. Immunol. 85 1991 41 47
9. R. Holmdahl, and L. Jansson Estrogen-induced suppression of collagen-induced arthritis: III. Adult thymectomy does not affect the course of arthritis or the estrogen-mediated suppression of T-cell immunity Brain Behav. Immun. 2 1988 123 132
10. L. Jansson, and R. Holmdahl Oestrogen-induced suppression of collagen arthritis; 17 beta-estradiol is therapeutically active in normal and castrated F1 hybrid mice of both sexes Clin. Exp. Immunol. 89 1992 446 451
11. A. Langer-Gould, H. Garren, A. Slansky, P.J. Ruiz, and L. Steinman Late pregnancy suppresses relapses in experimental autoimmune encephalomyelitis: evidence for a suppressive pregnancy-related serum factor J. Immunol. 169 2002 1084 1091
12. J.A. Firth, and J.G. McLeod Pregnancy and multiple sclerosis J. Neurol., Neurosurg. Psychiatry 51 1988 495 500
13. K.A. Latham, A. Zamora, H. Drought, S. Subramanian, A. Matejuk, H. Offner, and E.F. Rosloniec Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis J. Immunol. 171 2003 5820 5827
14. H. Offner, A. Zamora, S. Subramanian, M. Polanczyk, A. Krogstad, D.L. Auci, E.E. Morgan, and C.L. Reading A synthetic androstene analogue inhibits collagen-induced arthritis Clin. Immunol. 110 2004 181 190
15. C. Du, M.W. Khalil, and S. Sriram Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice J. Immunol. 167 2001 7094
16. Y. Waksman, I. Hod, and A. Friedman Therapeutic effects of estradiol benzoate on development of collagen-induced arthritis (CIA) in the Lewis rat are mediated via suppression of the humoral response against denatured collagen type II (CII) Clin. Exp. Immunol. 103 1996 376 383
17. S. Subramanian, A. Matejuk, A. Zamora, A.A. Vandenbark, and H. Offner Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system J. Immunol. 170 2003 1548 1555
18. B.P. Leung, N. Sattar, A. Crilly, M. Prach, D.W. McCarey, H. Payne, R. Madhok, C. Campbell, J.A. Gracie, F.Y. Liew, and I.B. McInnes A novel anti-inflammatory role for simvastatin in inflammatory arthritis J. Immunol. 170 2003 1524 1530
19. G.T. Waites, and A. Whyte Effect of pregnancy on collagen-induced arthritis in mice Clin. Exp. Immunol. 67 1987 467 476
20. F. Hirahara, P.H. Wooley, H.S. Luthra, C.B. Coulam, M.M. Griffiths, and C.S. Cavid Collagen-induced arthritis and pregnancy in mice: the effects of pregnancy on collagen-induced arthritis and the high incidence of infertility in arthritic female mice Am. J. Reprod. Immunol. Microbiol. 11 1986 44 54
21. B.F. Bebo, A. Fyfe-Johnson, K. Adlard, A.G. Beam, A.A. Vandenbark, and H. Offner Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains J. Immunol. 166 2001 2080 2089
22. A. Ito, J.B.F. Bebo, A. Matejuk, A. Zamora, M. Silverman, A. Fyfe-Johnson, and H. Offner Estrogen treatment down-regulates TNF-α production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice J. Immunol. 167 2001 542 552
23. F.S. DiGiovine, G. Nuki, and G.W. Druff Tumor necrosis factor in synovial exudates Ann. Rheum. Dis. 47 1988 768 772
24. S.J. Hopkins, and A. Meager Cytokines in synovial fluid: II. The presence of tumor necrosis factor and interferon Clin. Exp. Immunol. 73 1988 88 92
25. L. Altomonte, A. Zoli, L. Mirone, P. Scolieri, and M. Magaro Serum levels of interleukin-1b, tumor necrosis factor-α and interleukin-2 in rheumatoid arthritis Clin. Rheumatol. 11 1992 202 205
26. K. Redlich, B. Gortz, S. Hayer, J. Zwerina, N. Doerr, P. Kostenuik, H. Bergmeister, G. Kollias, G. Steiner, J.S. Smolen, and G. Schett Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis Am. J. Pathol. 164 2004 543 555
27. F.M. Brannan, D. Chantry, A. Jackson, R.N. Maini, and M. Feldmann Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis Lancet 29 1989 244 247
28. S.L. Teitelbaum Bone resorption by osteoclasts Science 289 2000 1504 1508
29. J. Lam, S. Takeshita, J.E. Barker, O. Kanagawa, F.P. Ross, and S.L. Teitelbaum TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand J. Clin. Invest. 106 2000 1481 1488
30. D.R. Bertolini, G.E. Nedwin, T.S. Bringman, D.D. Smith, and G.R. Mundy Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factor Nature 319 1986 516 518
31. M. Odendal, K. Brady, and F. McDonald The localization of estrogen receptors on human osteoblasts: a preliminary optical and electron microscopic technique Cell Biochem. Biophys. 40 2004 237 248
32. T. Yoneda, N. Ishimaru, R. Arakaki, M. Kobayashi, T. Izawa, K. Moriyama, and Y. Hayashi Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand mediated osteoclastogenesis Endocrinology 145 2004 2384 2391
33. C. Roggia, Y. Gao, S. Cenci, M.N. Weitzmann, G. Toraldo, G. Isaia, and R. Pacifici Up-regulation of TNF-α producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo Proc. Natl. Acad. Sci. 98 2001 13960 13965
34. P. Richette, M.F. Dumontier, M. Fracois, L. Tsagris, C. Korwin-Smijowska, F. Raanou, and M.T. Corvol Dual effects of 17β-oestradiol on interleukin 1b-induced proteoglycan degradation in chondrocytes Ann. Rheum. Dis. 63 2004 191 199
35. P.R. Kramer, S.F. Kramer, and G. Guan 17b-estradiol regulates cytokine release through modulation of CD16 expression in macrophages and monocyte-derived macrophages Arthritis Rheum. 50 2004 1967 1975
36. J. Cheung, Y.T. Mak, S. Papaioannou, B.A. Evans, I. Fogelman, and G. Hampson Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappa G ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene J. Endocrinol. 177 2003 423 433
37. L. Xing, L. Carlson, B. Story, Z. Tai, P. Keng, U. Seibenlist, and B.F. Boyce Expression of either NF-kappa B p50 or p52 in osteoclast precursor is required for IL-1 induced bone resorption J. Bone Miner. Res. 18 2003 260 269
38. E. Jimi, K. Aoki, H. Saito, F. D'Acquisto, M.J. May, I. Nakamura, T. Sudo, T. Kojima, F. Okamoto, H. Fukushima, K. Okabe, K. Ohya, and S. Ghosh Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo Nat. Med. 10 2004 617 624
39. Y. Wen, S. Yang, R. Liu, E. Perez, K.D. Yi, P. Koulen, and J.W. Simpkins Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia Brain Res. 1008 2004 147 154
40. E. Galea, R. Santizo, D.L. Feinstein, P. Adamsom, J. Greenwood, H.M. Koening, and D.A. Pellgrino Estrogen inhibits NF kappa-B-dependent inflammation in brain endothelium without interfering with I kappa B degradation NeuroReport 13 2002 1469 1472
41. M. Mori, F. Tsukahara, T. Yoshioka, K. Irie, and H. Ohta Suppression by 17 beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors Life Sci. 75 2004 599 609