Biomedicine: A gender gap in autoimmunity

Science

Volumn 283, Issue 5406, 1999, Pages 1277-1278

  Whitacre, Caroline C ^a   Reingold, Stephen C ^b   O'Looney, Patricia A ^b   Blankenhorn, Elizabeth ^c   Brinley, Floyd ^c   Collier, Elaine ^c   Duquette, Pierre ^c   Fox, Howard ^c   Giesser, Barbara ^c   Gilmore, Wendy ^c   Lahita, Robert ^c   Lee Nelson, J ^c   Reiss, Carol ^c   Riskind, Peter ^c   Voskuhl, Rhonda ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b National Multiple Sclerosis Society   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; CYTOKINE RELEASE; GENETIC LINKAGE; HUMAN; IMMUNE RESPONSE; MULTIPLE SCLEROSIS; PREVALENCE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SEX DIFFERENCE; SHORT SURVEY; SYSTEMIC LUPUS ERYTHEMATOSUS; THYROIDITIS; TREATMENT PLANNING; ANIMAL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; BIOSYNTHESIS; CELLULAR IMMUNITY; FEMALE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MALE; PHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION; SEXUAL DEVELOPMENT; TH1 CELL; TH2 CELL;

CYTOKINE; HORMONE; SEX HORMONE;

ANIMALS; ANTIBODY FORMATION; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CYTOKINES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GONADAL STEROID HORMONES; HORMONES; HUMANS; IMMUNITY, CELLULAR; MALE; PREGNANCY; PREGNANCY COMPLICATIONS; SEX CHARACTERISTICS; TH1 CELLS; TH2 CELLS;

EID: 0033604943     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5406.1277     Document Type: Short Survey

References (4)

1. D. L. Jacobson, S. J. Grange, N. R. Rose, N. M. H. Graham, Clin. Immunol. Immunopathol. 84, 223 (1997).
2. P. B. Beeson, Am. J. Med. 96, 457 (1994).
3. www.sciencemag.org/feature/data/983519.shl. The full report compiled by the Task Force on Gender, Multiple Sclerosis and Autoimmunity discusses the effects of gender on susceptibility to and severity of autoimmune disease. The report reviews the existing data on sexual dimorphism in the immune response, sexual dimorphism in infectious diseases, sex hormone regulation of the immune/autoimmune response and possible mechanisms of hormone action.
4. S. Sawcer, P. Goodfellow, A. Compston, Trends Genet. 13, 234 (1997).