Probing for integrin αvβ3 binding of RGD peptides using fluorescence polarization

Bioconjugate Chemistry

Volumn 16, Issue 3, 2005, Pages 729-734

  Wang, Wei ^a   Wu, Qingping ^a   Pasuelo, Marites ^a   McMurray, John S ^a   Li, Chun ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BINDING ENERGY; CELL ADHESION; DIAGNOSIS; FLUORESCENCE; PEPTIDES; POLARIZATION;

ADHESION MOLECULES; FLUORESCENCE POLARIZATION; INTEGRINS; NONRADIOACTIVE; RGD PEPTIDE; SIMPLE++; SYNTHESIS AND CHARACTERIZATIONS; TUMOR ANGIOGENESIS; TUMOR INVASION; TUMOR METASTASIS;

PROBES;

ARGINYLGLYCYLASPARTIC ACID; VITRONECTIN RECEPTOR;

ARTICLE; BIOASSAY; CELL ADHESION; FLUORESCENCE POLARIZATION; HIGH THROUGHPUT SCREENING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN SYNTHESIS;

EID: 18844380738     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc049763s     Document Type: Article

References (25)

1. Hynes, R. O. (1992) Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
2. van Muijen, G. N., Jansen, K. F., Cornelissen, I. M., Smeets, D. F., Beck, J. L., and Ruiter, D. J. (1991) Establishment and characterization of a human melanoma cell line (mv3) which is highly metastatic in nude mice. Int. J. Cancer 48, 85-91.
3. Felding-Habermann, B., Mueller, B. M., Romerdahl, C. A., and Cheresh, D. A. (1992) Involvement of integrin alpha v gene expression in human melanoma tumorigenicity. J. Clin. Invest. 89, 2018-2022.
4. Mitjans, F., Sander, D., Adan, J., Sutter, A., Martinez, J. M., Jaggle, C. S., Moyano, J. M., Kreysch, H. G., Piulats, J., and Goodman, S. L. (1995) An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice. J. Cell Sci. 108 (Pt 8), 2825-2838.
5. Brooks, P. C., Clark, R. A., and Cheresh, D. A. (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264, 569-571.
6. Eliceiri, B. P., and Cheresh, D. A. (1999) The role of alpha v integrins during angiogenesis: Insights into potential mechanisms of action and clinical development. J. Clin. Invest. 103, 1227-1230.
7. Brooks, P. C., Stromblad, S., Klemke, R., Visscher, D., Sarkar, F. H., and Cheresh, D. A. (1995) Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest. 96, 1815-1822.
8. Varner, J. A., Nakada, M. T., Jordan, R. E., and Coller, B. S. (1999) Inhibition of angiogenesis and tumor growth by murine 7e3, the parent antibody of c7e3 fab (abciximab; reopro). Angiogenesis 3, 53-60.
9. Buerkle, M. A., Pahernik, S. A., Sutter, A., Jonczyk, A., Messmer, K., and Dellian, M. (2002) Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo. Br. J. Cancer 86, 788-795.
10. MacDonald, T. J., Taga, T., Shimada, H., Tabrizi, P., Zlokovic, B. V., Cheresh, D. A., and Laug, W. E. (2001) Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery 48, 151-157.
11. Boger, D. L., Goldberg, J., Silletti, S., Kessler, T., and Cheresh, D. A. (2001) Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase mmp2 to integrin alpha(v)beta(3). J. Am. Chem. Soc. 123, 1280-1288.
12. Haubner, R., Wester, H. J., Reuning, U., Senekowitsch-Schmidtke, R., Diefenbach, B., Kessler, H., Stocklin, G., and Schwaiger, M. (1999) Radiolabeled alpha(v)beta3 integrin antagonists: A new class of tracers for tumor targeting. J. Nucl. Med. 40, 1061-1071.
13. Kling, A., Backfisch, G., Delzer, J., Geneste, H., Graef, C., Hornberger, W., Lange, U. E. W., Lauterbach, A., Seitz, W., and Subkowski, T. (2003) Design and synthesis of 1,5- and 2,5-substituted tetrahydrobenzazepinones as novel potent and selective integrin [alpha]v[beta]3 antagonists. Bioorg. Med. Chem. 11, 1319-1341.
14. Hu, B., Finsinger, D., Peter, K., Guttenberg, Z., Barmann, M., Kessler, H., Escherich, A., Moroder, L., Bohm, J., Baumeister, W., Sui, S. F., and Sackmann, E. (2000) Intervesicle cross-linking with integrin alpha iib beta 3 and cyclic-rgd-lipopeptide. A model of cell-adhesion processes. Biochemistry 39, 12284-12294.
15. Lakowicz, J. (1999) Principles of fluorescence spectroscopy, 2nd ed., Kluwer Academic/Plenum, New York.
16. Nasir, M. S., and Jolley, M. E. (1999) Fluorescence polarization: An analytical tool for immunoassay and drug discovery. Comb. Chem. High Throughput Screen. 2, 177-190.
17. Cheresh, D. A. (1987) Human endothelial cells synthesize and express an arg-gly asp-directed adhesion receptor involved in attachment to fibrinogen and von willebrand factor. Proc. Natl. Acad. Sci. U. S. A. 84, 6471-6475.
18. Dechantsreiter, M. A., Planker, E., Matha, B., Lohof, E., Holzemann, G., Jonczyk, A., Goodman, S. L., and Kessler, H. (1999) N-Methylated cyclic rgd peptides as highly active and selective alpha(v)beta(3) integrin antagonists. J. Med. Chem. 42, 3033-3040.
19. Haubner, R., Wester, H. J., Weber, W. A., Mang, C., Ziegler, S. I., Goodman, S. L., Senekowitsch-Schmidtke, R., Kessler, H., and Schwaiger, M. (2001) Noninvasive imaging of alpha-(v)beta3 integrin expression using 18f-labeled rgd-containing glycopeptide and positron emission tomography. Cancer Res. 61, 1781-1785.
20. Janssen, M. L., Oyen, W. J., Dijkgraaf, I., Massuger, L. F., Frielink, C., Edwards, D. S., Rajopadhye, M., Boonstra, H., Corstens, F. H., and Boerman, O. C. (2002) Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. Cancer Res. 62, 6146-6151.
21. Chen, X., Park, R., Tohme, M., Shahinian, A. H., Bading, J. R., and Conti, P. S. (2004) Micropet and autoradiographic imaging of breast cancer alpha v-integrin expression using 18f- and 64cu-labeled RGD peptide. Bioconjugate Chem. 15, 41-49.
22. Haubner, R., Bruchertseifer, F., Bock, M., Kessler, H., Schwaiger, M., and Wester, H. J. (2004) Synthesis and biological evaluation of a (99m)tc-labeled cyclic rgd peptide for imaging the alphavbeta3 expression. Nuklearmedizin. 43, 26-32.
23. Xiong, J. P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L., and Arnaout, M. A. (2002) Crystal structure of the extracellular segment of integrin alpha vbeta3 in complex with an Arg-Gly-Asp ligand. Science 296, 151-155.
24. Thumshirn, G., Hersel, U., Goodman, S. L., and Kessler, H. (2003) Multimeric cyclic RGD peptides as potential tools for tumor targeting: Solid-phase peptide synthesis and chemoselective oxime ligation. Chemistry 9, 2717-2725.
25. Janssen, M., Oyen, W. J. G., Massuger, L. F. A. G., Frielink, C., Dijkgraaf, I., Edwards, D. S., Radjopadhye, M., Corstens, F. H. M., and Boerman, O. C. (2002) Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting. Cancer Biother. Radiopharm. 17, 641-646.