Acute analgesic effect of loperamide as compared to morphine after intrathecal administration in rat

Indian Journal of Experimental Biology

Volumn 43, Issue 5, 2005, Pages 425-429

  Ray, Subrata Basu ^a   Verma, Dilip ^a   Wadhwa, Shashi ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Analgesia; Calcium channel antagonist; Loperamide; Morphine; Mu opioid receptor

Indexed keywords

ANALGESIC AGENT; LOPERAMIDE; MORPHINE;

ANIMAL; ARTICLE; INTRASPINAL DRUG ADMINISTRATION; MALE; RAT; WISTAR RAT;

ANALGESICS; ANIMALS; INJECTIONS, SPINAL; LOPERAMIDE; MALE; MORPHINE; RATS; RATS, WISTAR;

EID: 18844362447     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Fang F G, Fields H L & Lee N M, Action at the mu receptor is sufficient ot explain the supraspinal analgesic effect of opiates, J Pharmacol Exp Ther, 238 (1986) 1039.
2. DeHaven-Hudkins D L, Cortes Burgos L, Cassel J A, Daubert J D, Dehaven R N, Mansson E, Nagasaka H, Yu G & Yaksh T, Loperamide (ADL 2-1294) an opioid antihyperalgesic agent with peripheral selectivity, J Pharmacol Exp Ther, 289 (1999) 494.
3. Gutstein H B & Akil H, Opioid analgesics, in Goodman & Gilman's The pharmacological basis of therapeutics (Mcgraw-Hill, USA) 2001, 594.
4. Schinkel A H, Wagenaar E, Mol C A, van Deemter L, P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs, J Clin Invest, 97 (1996) 2517.
5. Nozaki-Taguchi N & Yaksh T L, Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist - loperamide, Anaesthesiology, 90 (1999) 225.
6. Emerich D F, Snodgrass P, Pink M, Bloom F & Bartus R T, Central analgesic actions of loperamide following transient permeation of the blood brain barrier with cereport™ (RMP-7), Brain Res, 801 (1998) 259.
7. 2+ channels, Neurosci Res, 46 (2003) 493.
8. Gupta H, Ray S B & Wadhwa S, Synergistic interaction between morphine and nimodipine produces acute analgesic effect on intrathecal administration in rat [submitted for publication Indian J Med Res (2004); application for patent has been filed (1535/Del/2004 dated 18-8-04)].
9. Verma D, Ray S B, Patro I, Wadhwa S, Enhanced analgesic effect of morphine-nimodipine combination as compared to morphine or nimodipine alone after spinal or systemic administration in mice (unpublished) 2004.
10. Malkmus S A & Yaksh T, Intrathecal catheterization and drug delivery in the rat, in Pain research, edited by Z David Luo (Humana Press, New Jersey) 2004, 119.
11. Mestre C, Pelissier T, Fialip J, Wilcox G & Eschalier A, A method to perform direct transcutaneous intrathecal injection in rats, J Pharmacol Toxicol Methods, 32 (1994) 197.
12. Church J, Fletcher E J, Abdel-Hamid K & MacDonald J F, Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons, Mol Pharmacol, 45 (1994) 747.
13. Raynolds I J, Could R J & Snyder S H, Loperamide: Blockade of calcium channels as a mechanism for antidiarrhoeal effects, J Pharmacol Exp Ther, 231 (1984) 628.
14. Shannon H E & Lutz E A, Comparison of the peripheral and central effects of opioids agonists loperamide and morphine in the formalin test in rats, Neuropharmacology, 42 (2002) 253.