Neural basis of eye gaze processing deficits in autism

Brain

Volumn 128, Issue 5, 2005, Pages 1038-1048

  Pelphrey, Kevin A ^a,c,d   Morris, James P ^a   McCarthy, Gregory ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Autism; Eye gaze; Functional MRI

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ATTENTION; AUTISM; BRAIN REGION; CLINICAL ARTICLE; COGNITION; COMPREHENSION; CONTROLLED STUDY; EXPECTATION; FEMALE; GAZE; HUMAN; IMAGING SYSTEM; INFORMATION PROCESSING; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SUPERIOR TEMPORAL SULCUS; TASK PERFORMANCE; VIRTUAL REALITY; VISUAL FIELD;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ATTENTION; AUTISTIC DISORDER; BRAIN; BRAIN MAPPING; EYE MOVEMENTS; FEMALE; FIXATION, OCULAR; HUMANS; INTENTION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SOCIAL PERCEPTION; TEMPORAL LOBE; VISUAL PERCEPTION;

EID: 18744409803     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awh404     Document Type: Article

References (46)

1. Allison T, Puce A, McCarthy G. Social perception from visual cues: role of the STS region. Trends Cogn Sci 2000; 4: 267-78.
2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders-IV. Washington, DC: American Psychiatric Association; 1994.
3. Baron-Cohen S. Mindblindness: an essay on autism and theory of mind. Cambridge (MA): MIT Press; 1995.
4. Baron-Cohen S, Campbell R, Karmiloff-Smith A, Grant J, Walker J. Are children with autism blind to the mentalistic significance of the eyes? Br J Dev Psychol 1999a; 13: 379-98.
5. Baron-Cohen S, Ring HA, Wheelwright S, Bullmore ET, Brammer MJ, Simmons A, et al. Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci 1999b; 11: 1891-8.
6. Baron-Cohen S, Wheelwright S, Hill J. The 'reading the mind in the eyes' test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001; 42: 241-52.
7. Blakemore SJ, Boyer P, Pachot-Clouard M, Meltzoff A, Segebarth C, Decety J. The detection of contingency and animacy from simple animations in the human brain. Cereb Cortex 2003; 13: 837-44.
8. Boddaert N, Belin P, Chabane N, Poline JB, Barthélémy C, Mouren-Simeoni MC, et al. Perception of complex sounds: abnormal pattern of cortical activation in autism. Am J Psychiatry 2003; 160: 2057-60.
9. Boddaert N, Chabane N, Gervais H, Good CD, Bourgeois M, Plumet MH, et al. Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study. Neuroimage 2004; 23: 364-9.
10. Brothers L. The social brain: a project for integrating primate behavior and neurophysiology in a new domain. Concept Neurosci 1990; 1: 27-51.
11. Castelli F, Frith C, Happé F, Frith U. Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 2002; 125: 1839-49.
12. Critchley HD, Elliott R, Mathias CJ, Dolan RJ. Neural activity relating to generation and representation of galvanic skin conductance responses: a functional magnetic resonance imaging study. J Neurosci 2000; 20: 3033-40.
13. Dawson G, Meltzoff A, Osterling J, Rinaldi J. Neuropsychological correlates of early symptoms of autism. Child Dev 1998; 69: 1277-85.
14. Dennett DC. The intentional stance. Cambridge (MA): MIT Press; 1987.
15. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnet Res Med 1995; 33: 636-47.
16. Frith CD, Frith U. Interacting minds-a biological basis. Science 1999; 286: 1692.
17. Gallagher HL, Happé F, Brunswick N, Fletcher PC, Frith U, Frith CD. Reading the mind in cartoons and stories: an fMRI study of 'theory of mind' in verbal and nonverbal tasks. Neuropsychologia 2000; 38: 11-21.
18. Gervais H, Belin P, Boddaert N, Leboyer M, Coez A, Sfaello I, et al. Abnormal cortical voice processing in autism. Nat Neurosci 2004; 7: 801-2.
19. Glover GH, Law CS. Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts. Magn Reson Med 2001; 46: 515-22.
20. Grèzes J, Frith CD, Passingham RE. Inferring false beliefs from the actions of oneself and others: an fMRI study. Neuroimage 2004; 21: 744-50.
21. Guo H, Song AW. Single-shot spiral image acquisition with embedded z-shimming for susceptibility signal recovery. J Magn Reson Imag 2003; 18: 389-95.
22. Hoffman EA, Haxby JV. Distinct representations of eye gaze and identity in the distributed human neural system for face perception. Nat Neurosci 2000; 3: 80-4.
23. Just MA, Cherkassky VL, Keller TA, Minshew NJ. Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain 2004; 127: 1811-21.
24. Kanner L. Autistic disturbances of affective contact. Nervous Child 1943; 2: 217-50.
25. Klin A, Jones W, Schultz R, Volkmar F, Cohen D. Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. Arch Gen Psychol 2002; 59: 809-16.
26. Leekam SR, Hunnisett E, Moore C. Targets and cues: gaze-following in children with autism. J Child Psychol Psyc 1998; 39: 951-62.
27. Leekam SR, Lopez B, Moore C. Attention and joint attention in preschool children with autism. Dev Psychol 2000; 36: 261-73.
28. Levitt JG, Blanton RE, Smalley S, Thompson PM, Guthrie D, McCracken JT, et al. Cortical sulcal maps in autism. Cereb Cortex 2003; 13: 728-35.
29. Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994; 24: 659-85.
30. Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, et al. The Autism Diagnostic Observation Schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 2000; 307: 205-23.
31. Loveland KA, Landry SH. Joint attention and language in autism and developmental language delay. J Autism Dev Disord 1986; 16: 335-49.
32. Mundy P, Sigman M, Ungerer J, Sherman T. Defining the social deficits of autism: the contribution of non-verbal communication measures. J Child Psychol Psychiatry 1986; 27: 657-69.
33. Ohnishi T, Matsuda H, Hashimoto T, Kunihiro T, Nishikawa M, Uema T, et al. Abnormal regional blood flow in childhood autism. Brain 2000; 123: 1838-44.
34. Pelphrey KA, Sasson N, Reznick JS, Paul G, Goldman B, Piven J. Visual scanning of faces in autism. J Autism Dev Disord 2002; 32: 249-61.
35. Pelphrey KA, Singerman JD, Allison T, McCarthy G. Brain activation evoked by perception of gaze shifts: the influence of context. Neuropsychologia 2003; 41: 156-70.
36. Pelphrey KA, Viola RJ, McCarthy G. When strangers pass: processing of mutual and averted gaze in the superior temporal sulcus. Psychol Sci 2004a; 15: 598-603.
37. Pelphrey KA, Morris JP, McCarthy G. Grasping the intentions of others: the perceived intention of an action influences activity in the superior temporal sulcus during social perception. J Cog Neurosci 2004b; 16: 1706-16.
38. Perani D, Fazio F, Borghese NA, Tettamanti M, Ferrari S, Decety J, et al. Different brain correlates for watching real and virtual hand actions. Neuroimage 2001; 14: 749-58.
39. Premack D, Woodruff G. Does the chimpanzee have a theory of mind? Behav Brain Sci 1978; 4: 515-26.
40. Puce A, Allison T, Bentin S, Gore JC, McCarthy G. Temporal cortex activation in humans viewing eye and mouth movements. J Neurosci 1998; 18: 2188-99.
41. Vogeley K, Bussfeld P, Newen A, Herrman S, Happé F, Falkai P, et al. Mind reading: neural mechanisms of theory of mind and self-perspective. Neuroimage 2001; 14: 170-81.
42. Voyvodic JT. Real-time fMRI paradigm control, physiology, and behavior combined with near real-time statistical analysis. Neuroimage 1999; 10: 91-106.
43. Waterhouse L, Fein D, Modahl C. Neuromechanisms in autism. Psychol Rev 1996; 103: 457-89.
44. Wicker B, Michel F, Henaff MA, Decety J. Brain regions involved in the perception of gaze: a PET study. Neuroimage 1998; 8: 221-7.
45. Xiong J, Gao J, Lancaster JL, Fox PT. Clustered pixels analysis for functional MRI activation studies of the human brain. Hum Brain Mapp 1995; 3: 287-301.
46. Zilbovicius M, Boddaert N, Belin P, Poline JB, Remy P, Mangin JF, et al. Temporal lobe dysfunction in childhood autism: a PET study. Am J Psychiatry 2000; 157: 1988-93.