Total synthesis of the squalene synthase inhibitor zaragozic acid C

Chemical and Pharmaceutical Bulletin

Volumn 53, Issue 1, 2005, Pages 1-10

  Nakamura, Seiichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Aldol reaction; Carbonyl ylide cycloaddition; Internal ketalization; Olefin cross metathesis; Total synthesis; Zaragozic acid

Indexed keywords

6,7 DIDEOXYSQUALESTATIN H5; ESTER DERIVATIVE; NATURAL PRODUCT; SQUALENE SYNTHASE INHIBITOR; SQUALESTATIN; TARTARIC ACID; TARTARIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZARAGOZIC ACID A; ZARAGOZIC ACID C; ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; SQUALENE SYNTHASE;

ALDOL REACTION; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; CATALYSIS; CYCLOADDITION; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; REVIEW; RING CLOSING METATHESIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS; DRUG ANTAGONISM; METABOLISM; SYNTHESIS;

BICYCLO COMPOUNDS, HETEROCYCLIC; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE;

EID: 18744385558     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.53.1     Document Type: Review

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