Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

Angewandte Chemie - International Edition

Volumn 42, Issue 43, 2003, Pages 5351-5355

  Nakamura, Seiichi ^a   Hirata, Yuuki ^a   Kurosaki, Takahiro ^a   Anada, Masahiro ^a   Kataoka, Osamu ^a   Kitagaki, Shinji ^a   Hashimoto, Shunichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Carbonyl ylides; Cycloaddition; Diazo compounds; Metathesis; Total synthesis

Indexed keywords

ADDITION REACTIONS; CATALYSIS; ENZYME INHIBITION; ESTERS; ISOMERS; OLEFINS; SYNTHESIS (CHEMICAL);

CROSS-METATHESIS; CYCLOADDITION;

ORGANIC ACIDS;

CARBONYL DERIVATIVE; SQUALENE SYNTHASE INHIBITOR; ZARAGOZIC ACID C;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL PROCEDURES; CYCLOADDITION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

AZO COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; CYCLIZATION; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; MOLECULAR STRUCTURE; STEREOISOMERISM; TRICARBOXYLIC ACIDS;

EID: 0344875710     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352629     Document Type: Article

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