Transcript regulation of human telomerase reverse transcriptase by c-myc and mad1

Acta Biochimica et Biophysica Sinica

Volumn 37, Issue 1, 2005, Pages 32-38

  Zou, Lin ^a   Zhang, Peng Hui ^a   Luo, Chun Li ^a   Tu, Zhi Guang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

c myc; mad1; hTERT promoter; Transcript regulation

Indexed keywords

MYC PROTEIN; PROTEIN MAD1; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; E BOX ELEMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; EUKARYOTE; EXPRESSION VECTOR; GENE CONSTRUCT; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTANT; PLASMID; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; TRANSCRIPTION REGULATION; WILD TYPE;

EUKARYOTA;

EID: 18644384335     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: 10.1093/abbs/37.1.32     Document Type: Article

References (27)

1. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR et al. The RNA component of human telomerase. Science, 1995, 269 (5228): 1236-1241
2. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB et al. Telomerase catalytic subunit homologs from fission yeast and human. Science, 1997, 277(5328): 955-959
3. Shay JW. Telomerase in human development and cancer. J Cell Physiol, 1997, 173(2): 266-270
4. Cerni C. Telomeres, telomerase, and myc. An update. Mutat Res, 2000, 462 (1): 31-47
5. Poole JC, Andrews LG, Tollefsbol TO. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene, 2001, 269(1-2): 1-12
6. FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK et al. Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. Oncogene, 1999, 18(15): 2489-2498
7. Gunes C, Lichtsteiner S, Vasserot AP, Englert C. Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res, 2000, 60(8): 2116-2121
8. Queva C, Hurlin PJ, Foley KP, Eisenman RN. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Oncogene, 1998, 16(8): 967-977
9. James L, Eisenman RN. Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo. Proc Natl Acad Sci USA, 2002, 99(16): 10429-10434
10. Zou L, Luo CL, Tu ZG, Zhang PH. Expression of hTERT and c-myc mRNA in transitional cell carcinoma of the bladder (TCCB). Chin Med J, 2002, 15(5), netprints
11. Barr LF, Campbell SE, Diette GB, Gabrielson EW, Kim S, Shim H, Dang CV. c-Myc suppresses the tumorigenicity of lung cancer cells and down-regulates vascular endothelial growth factor expression. Cancer Res, 2000, 60(1): 143-149
12. Horikawa I, Cable PL, Mazur SJ, Appella E, Afshari CA, Barrett JC. Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression. Mol Biol Cell, 2002, 13 (8): 2585-2597
13. Wu KJ, Grandori C, Amacker M, Simon-Vermot N, Polack A, Lingner J, Dalla-Favera R. Direct activation of TERT transcription by c-myc. Nat Genet, 1999, 21(2): 220-224
14. Komata T, Kondo Y, Kanzawa T, Ito H, Hirohata S, Koga S, Sumiyoshi H et al. Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells. Hum Gene Ther, 2002, 13(9): 1015-1025
15. Smith AG, Popov N, Imreh M, Axelson H, Henriksson M. Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells. J Cell Biochem, 2004, 92(6): 1282-1295
16. Casillas MA, Brotherton SL, Andrews LG, Ruppert JM, Tollefsbol TO. Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements. Gene, 2003, 316: 57-65
17. Meeker AK, de Marzo AM. Recent advances in telomere biology: Implications for human cancer. Curr Opin Oncol, 2004, 16(1): 32-38
18. Glas AS, Roos D, Deutekom M, Zwinderman AH, Bossuyt PM, Kurth KH. Tumor markers in the diagnosis of primary bladder cancer. J Urol, 2003, 169(6): 1975-1982
19. Maida Y, Kyo S, Kanaya T, Wang Z, Yatabe N, Tanaka M, Nakamura M et al. Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway. Oncogene, 2002, 21(26): 4071-4079
20. Lin Y, Xie WF, Chen WZ. Regulation of human telomerase reverse transcriptase by c-myc in vitro. J Chin Tumor Biol Ther, 2001, 8(1): 34-36
21. Chen CJ, Kyo S, Liu YC, Cheng YL, Hsieh CB, Chan DC, Yu JC et al. Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma. World J Gastroenterol, 2004, 10(5): 638-642
22. Oh S, Song YH, Kim UJ, Yim J, Kim TK. In vivo and in vitro analyses of myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells. Biochem Biophys Res Commun, 1999, 63(2): 361-366
23. Nikiforov MA, Popov N, Kotenko I, Henriksson M, Cole MD. The Mad and Myc basic domains are functionally equivalent. J Biol Chem, 2003, 278(13): 11094-11099
24. Cerezo A, Kalthoff H, Schuermann M, Schafer B, Boukamp P. Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT. J Cell Sci, 2002, 115(Pt 6): 1305-1312
25. Xu D, Popov N, Hou M, Wang Q, Bjorkholm M, Gruber A, Menkel AR et al. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci USA, 2001, 98(7): 3826-3831
26. Rama S, Suresh Y, Rao AJ. TGF beta1 induces multiple independent signals to regulate human trophoblastic differentiation: mechanistic insights. Mol Cell Endocrinol, 2003, 206(1-2): 123-136
27. Nogues G, Kadener S, Cramer P, Bentley D, Kornblihtt AR. Transcriptional activators differ in their abilities to control alternative splicing. J Biol Chem, 2002, 277(45): 43110-43114