Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1

Journal of Medicinal Chemistry

Volumn 48, Issue 10, 2005, Pages 3613-3620

  Moth, Christopher W ^a   Prusakiewicz, Jeffrey J ^a   Marnett, Larry J ^a   Lybrand, Terry P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN DERIVATIVE; INDOMETHACIN ETHANOLAMIDE DERIVATIVE; ISOENZYME; LIGAND; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; SIMULATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; ETHANOLAMINES; HYDROGEN BONDING; INDOMETHACIN; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SHEEP; STEREOISOMERISM; THERMODYNAMICS;

EID: 18644380549     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0494164     Document Type: Article

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