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Volumn 31, Issue 7, 1996, Pages 508-515

Advanced glycation endproducts (AGEs) induce oxidant stress in the gingiva: A potential mechanism underlying accelerated periodontal disease associated with diabetes

Author keywords

Diabetes; Glycation; Oxidation; Periodontum

Indexed keywords

ADVANCED GLYCATION END PRODUCT; HEME OXYGENASE; STREPTOZOCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

EID: 0030254624     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1996.tb01417.x     Document Type: Article
Times cited : (228)

References (55)
  • 1
    • 0009021580 scopus 로고
    • Influence of diabetes mellitus on the severity of periodontal disease
    • Belting C, Hinker J, Dummett C. Influence of diabetes mellitus on the severity of periodontal disease. J Periodontol 1964; 35: 476-480.
    • (1964) J Periodontol , vol.35 , pp. 476-480
    • Belting, C.1    Hinker, J.2    Dummett, C.3
  • 2
    • 0014897871 scopus 로고
    • Diabetes mellitus and periodontal disease: Two year longitudinal observations. Part I
    • Cohen D, Friedman L, Shapiro J, Kyle GC, Franklin S. Diabetes mellitus and periodontal disease: two year longitudinal observations. Part I. J Periodontol 1970; 41: 709-712.
    • (1970) J Periodontol , vol.41 , pp. 709-712
    • Cohen, D.1    Friedman, L.2    Shapiro, J.3    Kyle, G.C.4    Franklin, S.5
  • 3
    • 0016734787 scopus 로고
    • Dental disease in children with diabetes mellitus
    • Bernick C, Cohen D, Baker L, Laster L. Dental disease in children with diabetes mellitus. J Periodontol 1975; 46: 241-245.
    • (1975) J Periodontol , vol.46 , pp. 241-245
    • Bernick, C.1    Cohen, D.2    Baker, L.3    Laster, L.4
  • 4
    • 0018176745 scopus 로고
    • Periodontal findings in diabetic and nondiabetic patients
    • Sznajder R, Carraro J, Rugna S, Sereday M. Periodontal findings in diabetic and nondiabetic patients. J Periodontol 1978; 49: 445-448.
    • (1978) J Periodontol , vol.49 , pp. 445-448
    • Sznajder, R.1    Carraro, J.2    Rugna, S.3    Sereday, M.4
  • 5
    • 0019769750 scopus 로고
    • Accelerated periodontal breakdown in uncontrolled diabetes; pathogenesis and treatment
    • Bartolucci E, Parks R. Accelerated periodontal breakdown in uncontrolled diabetes; pathogenesis and treatment. Oral Surg Oral Med Oral Path 1981; 52: 387-390.
    • (1981) Oral Surg Oral Med Oral Path , vol.52 , pp. 387-390
    • Bartolucci, E.1    Parks, R.2
  • 7
    • 0020854904 scopus 로고
    • Case report: A patient with severe periodontitis in conjunction with adult-onset diabetes
    • Ureles S. Case report: a patient with severe periodontitis in conjunction with adult-onset diabetes. Compend Contin Educ Dent 1983; 4: 522-528.
    • (1983) Compend Contin Educ Dent , vol.4 , pp. 522-528
    • Ureles, S.1
  • 8
    • 0020134967 scopus 로고
    • Prevalence of periodontal disease in insulin-dependent diabetes mellitus
    • Cianciola L, Park B, Bruck E, Mosorich L, Genco RJ. Prevalence of periodontal disease in insulin-dependent diabetes mellitus. J Am Dent Assoc 1982; 104: 653-660.
    • (1982) J Am Dent Assoc , vol.104 , pp. 653-660
    • Cianciola, L.1    Park, B.2    Bruck, E.3    Mosorich, L.4    Genco, R.J.5
  • 9
    • 0026477631 scopus 로고
    • Periodontal conditions in insulin dependent diabetes mellitus
    • Safkan-Seppala B, Ainamo J. Periodontal conditions in insulin dependent diabetes mellitus. J Clin Periodontol 1992; 19: 628-632.
    • (1992) J Clin Periodontol , vol.19 , pp. 628-632
    • Safkan-Seppala, B.1    Ainamo, J.2
  • 10
    • 0020039967 scopus 로고
    • The development of an altered gingival crevicular microflora in the alloxan-diabetic rat
    • McNamara T, Ramamurthy N, Mulvihill J, Golub L. The development of an altered gingival crevicular microflora in the alloxan-diabetic rat. Arch Oral Biol 1982; 27: 217-223.
    • (1982) Arch Oral Biol , vol.27 , pp. 217-223
    • McNamara, T.1    Ramamurthy, N.2    Mulvihill, J.3    Golub, L.4
  • 11
    • 0015239227 scopus 로고
    • Chemotaxis of PMNs from patients with diabetes
    • Mowat A, Baum J. Chemotaxis of PMNs from patients with diabetes. New Engl J Med 1971; 284: 621-627.
    • (1971) New Engl J Med , vol.284 , pp. 621-627
    • Mowat, A.1    Baum, J.2
  • 12
    • 0020446274 scopus 로고
    • Neutrophil functional activity in juvenile and adult onset diabetic patients with mild and severe periodontitis
    • Biassada N, Manouchehr-Pour M. Haddow M, Spagnuolo P. Neutrophil functional activity in juvenile and adult onset diabetic patients with mild and severe periodontitis. J Periodont Res 1982; 17: 500-502.
    • (1982) J Periodont Res , vol.17 , pp. 500-502
    • Biassada, N.1    Manouchehr-Pour, M.2    Haddow, M.3    Spagnuolo, P.4
  • 13
    • 0026784628 scopus 로고
    • Glucose and diabetic vascular disease
    • Ruderman N, Williamson J, Brownlee M. Glucose and diabetic vascular disease. FASEB J 1992; 6: 2905-2914.
    • (1992) FASEB J , vol.6 , pp. 2905-2914
    • Ruderman, N.1    Williamson, J.2    Brownlee, M.3
  • 14
    • 0024852380 scopus 로고
    • Structure elucidation of a senescence cross-link from human extracellular matrix: Implication of pentoses in the aging process
    • Sell D, Monnier V. Structure elucidation of a senescence cross-link from human extracellular matrix: implication of pentoses in the aging process. J Biol Chem 1989; 264: 21597-21602.
    • (1989) J Biol Chem , vol.264 , pp. 21597-21602
    • Sell, D.1    Monnier, V.2
  • 15
    • 0023950461 scopus 로고
    • Advanced glycosylation endproducts in tissue and the biochemical basis of diabetic complications
    • Brownlee M, Cerami A, Vlassara H. Advanced glycosylation endproducts in tissue and the biochemical basis of diabetic complications. N Engl J Med 1988; 318: 1315-1320.
    • (1988) N Engl J Med , vol.318 , pp. 1315-1320
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 16
    • 0027184474 scopus 로고
    • Lipid advanced glycosylation: Pathway for lipid oxidation in vivo
    • Bucala R, Makita Z, Koschinsky T, Cerami A, Vlassara H. Lipid advanced glycosylation: pathway for lipid oxidation in vivo. PNAS (USA) 1993; 90: 6434-6438.
    • (1993) PNAS (USA) , vol.90 , pp. 6434-6438
    • Bucala, R.1    Makita, Z.2    Koschinsky, T.3    Cerami, A.4    Vlassara, H.5
  • 17
    • 0025732948 scopus 로고
    • Role of oxidative stress in the development of complications in diabetes
    • Baynes J. Role of oxidative stress in the development of complications in diabetes. Diabetes 1991; 40: 405-412.
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.1
  • 18
    • 0028304625 scopus 로고
    • Enhanced cellular oxidant stress by the interaction of advanced glycation endproducts with their receptors/binding proteins
    • Yan SD, Schmidt AM, Anderson G, et al. Enhanced cellular oxidant stress by the interaction of advanced glycation endproducts with their receptors/binding proteins. J Biol Chem 1994; 269: 9889-9897.
    • (1994) J Biol Chem , vol.269 , pp. 9889-9897
    • Yan, S.D.1    Schmidt, A.M.2    Anderson, G.3
  • 19
    • 0024207597 scopus 로고
    • Antioxidant enzyme alterations in experimental clinical diabetes
    • Godin D, Wohaieb S, Garnett M, Goumeniouk A. Antioxidant enzyme alterations in experimental clinical diabetes. Mol Cell Biochem 1988; 84: 223-231.
    • (1988) Mol Cell Biochem , vol.84 , pp. 223-231
    • Godin, D.1    Wohaieb, S.2    Garnett, M.3    Goumeniouk, A.4
  • 20
    • 0023576328 scopus 로고
    • Alterations in free radical tissue-defense mechanisms in streptozotocin-induced diabetes in rat
    • Wohaieb S, Godin D Alterations in free radical tissue-defense mechanisms in streptozotocin-induced diabetes in rat. Diabetes 1987; 36: 1014-1018.
    • (1987) Diabetes , vol.36 , pp. 1014-1018
    • Wohaieb, S.1    Godin, D.2
  • 21
    • 0026056573 scopus 로고
    • Reduced vitamin e and increased lipofuscin products in erythrocytes of diabetic rats
    • Jain S, Levine S, Duett J, Hollier B. Reduced vitamin E and increased lipofuscin products in erythrocytes of diabetic rats. Diabetes 1991; 40: 1241-1244.
    • (1991) Diabetes , vol.40 , pp. 1241-1244
    • Jain, S.1    Levine, S.2    Duett, J.3    Hollier, B.4
  • 23
    • 2742545929 scopus 로고
    • Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy: Soluble receptor for advanced glycation endproducts blocks hyperpermeability
    • Wautier JL, Zoukounan C, Chappey O, et al. Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy: soluble receptor for advanced glycation endproducts blocks hyperpermeability. Clin Res 1995; 215A.
    • (1995) Clin Res
    • Wautier, J.L.1    Zoukounan, C.2    Chappey, O.3
  • 24
    • 2742591877 scopus 로고
    • Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation endproducts
    • Schmidt AM, Yan SD, Brett J, Mora R, Nowygrod R, Stern D. Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation endproducts. J Clin Invest 1993; 267: 5133-5138.
    • (1993) J Clin Invest , vol.267 , pp. 5133-5138
    • Schmidt, A.M.1    Yan, S.D.2    Brett, J.3    Mora, R.4    Nowygrod, R.5    Stern, D.6
  • 25
    • 0026650438 scopus 로고
    • Isolation and characterization of binding proteins for advanced glycation endproducts from lung tissue which are present on the endothelial cell surface
    • Schmidt AM, Vianna M, Gerlach M, et al. Isolation and characterization of binding proteins for advanced glycation endproducts from lung tissue which are present on the endothelial cell surface. J Biol Chem 1992; 267: 14987-14997.
    • (1992) J Biol Chem , vol.267 , pp. 14987-14997
    • Schmidt, A.M.1    Vianna, M.2    Gerlach, M.3
  • 26
    • 0019765424 scopus 로고
    • Production of antisera with small doses of immunogen: Multiple intradermal injections
    • Vaitukaitis, J. Production of antisera with small doses of immunogen: multiple intradermal injections. Meth Enzymol 1981; 73: 46-52.
    • (1981) Meth Enzymol , vol.73 , pp. 46-52
    • Vaitukaitis, J.1
  • 27
    • 0028587238 scopus 로고
    • The receptor for advanced glycation endproducts (AGEs) has a central role in vessel wall interactions and gene activatioin in response to circulating AGE-proteins
    • Schmidt AM, Hasu M, Popov D, et al. The receptor for advanced glycation endproducts (AGEs) has a central role in vessel wall interactions and gene activatioin in response to circulating AGE-proteins. PNAS (USA) 1994; 91: 8807-8811.
    • (1994) PNAS (USA) , vol.91 , pp. 8807-8811
    • Schmidt, A.M.1    Hasu, M.2    Popov, D.3
  • 28
    • 0028023944 scopus 로고
    • Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress
    • Yan SD, Chen X, Schmidt AM, et al. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. PNAS (USA) 1994; 91: 7787-7791.
    • (1994) PNAS (USA) , vol.91 , pp. 7787-7791
    • Yan, S.D.1    Chen, X.2    Schmidt, A.M.3
  • 29
    • 0026659883 scopus 로고
    • Cloning and expression of RAGE:a cell surface receptor for advanced glycation endproducts of proteins
    • Neeper M, Schmidt AM, Brett J, et al. Cloning and expression of RAGE:a cell surface receptor for advanced glycation endproducts of proteins. J Biol Chem 1992; 267: 14998-15004.
    • (1992) J Biol Chem , vol.267 , pp. 14998-15004
    • Neeper, M.1    Schmidt, A.M.2    Brett, J.3
  • 30
    • 0025787479 scopus 로고
    • Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: Relationship to macrophage receptor for glucosemodified proteins
    • Yang Z, Makita J, Horii Y, et al. Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucosemodified proteins. J Exp Med 1991; 174: 515-524.
    • (1991) J Exp Med , vol.174 , pp. 515-524
    • Yang, Z.1    Makita, J.2    Horii, Y.3
  • 31
    • 0028364606 scopus 로고
    • Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors
    • El-Khoury J, Thomas CA, Loike J, Cao L, Silverstein SC. Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. J Biol Chem 1994; 269: 10197-10200.
    • (1994) J Biol Chem , vol.269 , pp. 10197-10200
    • El-Khoury, J.1    Thomas, C.A.2    Loike, J.3    Cao, L.4    Silverstein, S.C.5
  • 32
    • 0026657174 scopus 로고
    • Ferritin: A cytoprotective antioxidant stratagem of endothelium
    • Balla G, Jacob H, Balla J, et al. Ferritin: a cytoprotective antioxidant stratagem of endothelium. J Biol Chem 1992; 267: 18148-18153.
    • (1992) J Biol Chem , vol.267 , pp. 18148-18153
    • Balla, G.1    Jacob, H.2    Balla, J.3
  • 33
    • 0025105624 scopus 로고
    • Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured human skin fibroblasts
    • Keyse A, Applegate L, Tromvoukis Y, Tyrrell R. Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured human skin fibroblasts. Mol Cell Biol 1990; 10: 4967-4969
    • (1990) Mol Cell Biol , vol.10 , pp. 4967-4969
    • Keyse, A.1    Applegate, L.2    Tromvoukis, Y.3    Tyrrell, R.4
  • 34
    • 0027753114 scopus 로고
    • Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: Importance of extraction pH and influence of sample preservation and storage
    • Wasowicz W, Neve J, Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem 1993; 39: 2522-2526.
    • (1993) Clin Chem , vol.39 , pp. 2522-2526
    • Wasowicz, W.1    Neve, J.2    Peretz, A.3
  • 35
    • 0024211795 scopus 로고
    • Specific of the Thiobarbituric Acid Reaction: Its use in studies of lipid peroxidation
    • Knight JA, Pieper RK, McClellan L. Specific of the Thiobarbituric Acid Reaction: its use in studies of lipid peroxidation. Clin Chem 1988; 34: 2433-2438.
    • (1988) Clin Chem , vol.34 , pp. 2433-2438
    • Knight, J.A.1    Pieper, R.K.2    McClellan, L.3
  • 36
    • 0025369970 scopus 로고
    • The measurement and mechanism of lipid peroxidation in biological systems
    • Gutteridge JMC, Halliwell B The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 1990; 15: 129-135.
    • (1990) Trends Biochem Sci , vol.15 , pp. 129-135
    • Gutteridge, J.M.C.1    Halliwell, B.2
  • 37
    • 0028233384 scopus 로고
    • The endothelial cell binding site for advanced glycation endproducts consists of a complex: An integral membrane protein and a lactoferrinlike polypeptide
    • Schmidt AM, Mora R, Cao R, et al. The endothelial cell binding site for advanced glycation endproducts consists of a complex: an integral membrane protein and a lactoferrinlike polypeptide. J Biol Chem 1994; 269: 9882-9888.
    • (1994) J Biol Chem , vol.269 , pp. 9882-9888
    • Schmidt, A.M.1    Mora, R.2    Cao, R.3
  • 38
    • 0027718105 scopus 로고
    • Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues
    • Brett J, Schmidt AM, Yan SD, et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol 1993; 143: 1699-1712.
    • (1993) Am J Pathol , vol.143 , pp. 1699-1712
    • Brett, J.1    Schmidt, A.M.2    Yan, S.D.3
  • 39
    • 0026950004 scopus 로고
    • Endothelial cell leukocyte adhesion molecule-I and intercellular adhesion molecule-I expression in gingival tissue during health and experimentally-induced gingivitis
    • Moughal N, Adonogianaki E, Thornhill M, Kinanc D. Endothelial cell leukocyte adhesion molecule-I and intercellular adhesion molecule-I expression in gingival tissue during health and experimentally-induced gingivitis. J Periodent Res 1992; 27: 623-630.
    • (1992) J Periodent Res , vol.27 , pp. 623-630
    • Moughal, N.1    Adonogianaki, E.2    Thornhill, M.3    Kinanc, D.4
  • 40
    • 0025865317 scopus 로고
    • The inducible transcription activator NF-kappa B: Regulation by distinct protein subunits
    • Baeuerle P. The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. Biochim Biophys Acta 1991; 1072: 63-80.
    • (1991) Biochim Biophys Acta , vol.1072 , pp. 63-80
    • Baeuerle, P.1
  • 41
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV
    • Schreck R, Rieber P, Baeuerle P. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV. EMBO J 1991; 10: 2247-2258.
    • (1991) EMBO J , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.3
  • 42
    • 0027193894 scopus 로고
    • Endothelia nuclear factor kB and the initiation of the atherosclerotic lesion
    • Collins T. Endothelia nuclear factor kB and the initiation of the atherosclerotic lesion. Lab Invest 1993; 68: 499-508.
    • (1993) Lab Invest , vol.68 , pp. 499-508
    • Collins, T.1
  • 43
    • 0028373886 scopus 로고
    • Assessment of IL-6 in the pathogenesis of periodontal disease
    • Takahasi K,Takashiba S, Nagai A, et al. Assessment of IL-6 in the pathogenesis of periodontal disease. J Periodontol 1994; 65: 147-153.
    • (1994) J Periodontol , vol.65 , pp. 147-153
    • Takahasi, K.1    Takashiba, S.2    Nagai, A.3
  • 44
    • 0029088742 scopus 로고
    • Advanced glycation Endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-I) in cultured human umbilical vein endothelial cells and in mice: A potential mechanism for the accelerated vasculopathy of diabetes
    • Schmidt AM, Hori O, Chen JX, et al. Advanced glycation Endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-I) in cultured human umbilical vein endothelial cells and in mice: a potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 1995; 96: 1395-1403.
    • (1995) J Clin Invest , vol.96 , pp. 1395-1403
    • Schmidt, A.M.1    Hori, O.2    Chen, J.X.3
  • 45
    • 0024818401 scopus 로고
    • Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    • Osborn L, Hession C, Tizard R, et al. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 1989; 59: 1203-1211.
    • (1989) Cell , vol.59 , pp. 1203-1211
    • Osborn, L.1    Hession, C.2    Tizard, R.3
  • 46
    • 0025896795 scopus 로고
    • Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
    • Cybulsky M, Gimbrone M. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991; 251: 788-791.
    • (1991) Science , vol.251 , pp. 788-791
    • Cybulsky, M.1    Gimbrone, M.2
  • 47
    • 0028209658 scopus 로고
    • Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits
    • Richardson M, Hadcock S, DeReske M, Cybulsky M. Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits. Arterioscler Thromb 1994; 14: 760-769.
    • (1994) Arterioscler Thromb , vol.14 , pp. 760-769
    • Richardson, M.1    Hadcock, S.2    DeReske, M.3    Cybulsky, M.4
  • 48
    • 0025987488 scopus 로고
    • Localization of Interleukin-1 beta in human periodontal disease
    • Jandinski J, Stashenko P, Feder L, et al. Localization of Interleukin-1 beta in human periodontal disease. J Periodontol 1991; 62: 36-43.
    • (1991) J Periodontol , vol.62 , pp. 36-43
    • Jandinski, J.1    Stashenko, P.2    Feder, L.3
  • 49
    • 0025811915 scopus 로고
    • The role of inflammatory mediators in the pathogenesis of periodontal disease
    • Page R. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodont Res 1991; 26: 230-242.
    • (1991) J Periodont Res , vol.26 , pp. 230-242
    • Page, R.1
  • 50
    • 0026161944 scopus 로고
    • Immunologic mechanisms of pathogenesis in periodontal diseases: An assessment
    • Ranney R. Immunologic mechanisms of pathogenesis in periodontal diseases: an assessment. J Periodont Res 1991; 26: 243-254.
    • (1991) J Periodont Res , vol.26 , pp. 243-254
    • Ranney, R.1
  • 51
    • 0026163748 scopus 로고
    • Inflammatory mediators and the destruction of bone
    • Mundy G. Inflammatory mediators and the destruction of bone. J Periodont Res 1991; 26: 213-217.
    • (1991) J Periodont Res , vol.26 , pp. 213-217
    • Mundy, G.1
  • 52
    • 0025161581 scopus 로고
    • IL-1 regulation of procollagenase mRNA and protein in periodontal fibroblasts in vitro
    • Richards D, Rutherford R. IL-1 regulation of procollagenase mRNA and protein in periodontal fibroblasts in vitro. J Periodont Res 1990; 25: 222-229.
    • (1990) J Periodont Res , vol.25 , pp. 222-229
    • Richards, D.1    Rutherford, R.2
  • 53
    • 0025764664 scopus 로고
    • Production of gelatin-degrading matrix metalloproteinases and inhibitors by articular chondrocytes during their dedifferentiation by serial subcultures and under stimulation by IL-1 and TNF
    • Lefebvre V, Peeteers-Joris C, Vaes G. Production of gelatin-degrading matrix metalloproteinases and inhibitors by articular chondrocytes during their dedifferentiation by serial subcultures and under stimulation by IL-1 and TNF. Biochem Biophys Acta 1991; 1094: 8-18.
    • (1991) Biochem Biophys Acta , vol.1094 , pp. 8-18
    • Lefebvre, V.1    Peeteers-Joris, C.2    Vaes, G.3
  • 54
    • 0025792013 scopus 로고
    • Constitutive expression of a 92 kD gelatinase by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines
    • Unemori E, Hibbs M, Amento E. Constitutive expression of a 92 kD gelatinase by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Clin Invest 1991; 88: 1656-1662.
    • (1991) J Clin Invest , vol.88 , pp. 1656-1662
    • Unemori, E.1    Hibbs, M.2    Amento, E.3
  • 55
    • 0028391312 scopus 로고
    • Immunolocalization of matrix metalloproteinases and TIMP-1 in human gingival tissues from periodontitis patients
    • Meikle M, Hembry R, Holley J, Horton C, McFarlane C, Reynolds J. Immunolocalization of matrix metalloproteinases and TIMP-1 in human gingival tissues from periodontitis patients. J Periodont Res 1994; 29: 118-126
    • (1994) J Periodont Res , vol.29 , pp. 118-126
    • Meikle, M.1    Hembry, R.2    Holley, J.3    Horton, C.4    McFarlane, C.5    Reynolds, J.6


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