N-cycloalkanoyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 17, 2002, Pages 2475-2478

  Sidduri, Achyutharao ^a   Tilley, Jefferson W ^a   Hull, Kenneth ^a   Ping Lou, Jian ^a   Kaplan, Gerry ^a   Sheffron, Allen ^a   Chen, Li ^a   Campbell, Robert ^a   Guthrie, Robert ^a   Huang, Tai Nan ^a   Huby, Nicholas ^a   Rowan, Karen ^a   Schwinge, Virginia ^a   Renzetti, Louis M ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; PHENYLALANINE DERIVATIVE; VASCULAR CELL ADHESION MOLECULE 1; CYCLOALKANE DERIVATIVE; DRUG DERIVATIVE; PHENYLALANINE; VERY LATE ACTIVATION ANTIGEN 4;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG IDENTIFICATION; DRUG POTENCY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; IC 50; PROTEIN BINDING; SYNTHESIS;

CRYSTALLOGRAPHY, X-RAY; CYCLOPARAFFINS; HUMANS; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; MOLECULAR STRUCTURE; PHENYLALANINE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR CELL ADHESION MOLECULE-1;

EID: 18544371288     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00386-4     Document Type: Article

References (11)

1. WO 9910313